Sentences with phrase «alter the metabolism of»

Two decades of intensive pursuit have yielded a range of drugs that alter the metabolism of amyloid - β, but these have yet to fulfil expectations.

More work is needed to determine whether the findings on rapamycin hold true in animal models of Leigh syndrome and other neurodegenerative diseases, and to ascertain how exactly rapamycin is altering the metabolism of the cells.

Further research showed that the WWOX gene plays a role in the altered metabolism of cancer cells which are known to use glucose differently to normal cells.

The altered metabolism of two essential amino acids helps drive the development of the most common and lethal form of brain cancer, according to a new study led by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James).

When it comes to the safety of any herbal treatment, it's also important to consider the risk of potential drug - nutrient interactions or the ability for the herbal to alter the metabolism of a number of medications.

What's most surprising is that even after controlling for fiber intake, those on plant - based diets still had significantly lower risk, leading the researchers to suggest that meat itself may increase the risk of diverticular disease «by altering the metabolism of bacteria in the colon, which could lead to a weakening of the colon wall....»

Phenobarbital is removed from the body by the liver so good liver function is essential for phenobarbital use and phenobarbital can alter the metabolism of numerous other medications.

Differences in a dog's diet, body composition, and metabolic rate may alter the metabolism of phenobarbital.

In fact, viruses are on the border between living and non-living; they require another organism to reproduce and thrive; otherwise they are little more than a chemical compound with the potential to alter the metabolism of their hosts.

Not exact matches

Metabolism and weight: Chronic sleep deprivation may cause weight gain by affecting the way our bodies process and store carbohydrates, and by altering levels of hormones that affect our appetite.

«We found that there are differences in these microRNA profiles, and that the majority of the altered microRNAs influence metabolism,» said Molly Carney, medical student in the Penn State College of Medicine.

Furthermore, in the affected men the researchers observed an altered secretion of the intestinal hormones glucagon - like peptide - 1 (GLP - 1) and peptide YY (PYY), which contribute to the regulation of the glucose metabolism or body weight and whose secretion is subject to a particular circadian rhythm.

The article «Late - onset Caloric Restriction Alters Skeletal Muscle Metabolism by Modulating Pyruvate Metabolism» is published ahead of print in the American Journal of Physiology - Endocrinology and Metabolism.

The panel continues to recommend a three - part therapy that contains AZT, or the HIV inhibitor called TDF, in the place of stavudine, which can alter fat metabolism and cause nerve damage.

Components of indoor dust may signal human fat cells to grow and may alter metabolism, potentially contributing to weight problems, researchers report July 14 in Environmental Science & Technology.

«Remarkably, our findings suggest that composition of the gut microbiota influence and alter central carbon metabolism in a genotype independent manner.

New markers suggested include total mass of hemoglobin, altered expression of genes related to red blood cell metabolism, ironomics, storage lesions, and the presence of plasticizers from blood bags in athlete urine samples.

Researchers at the University of Turku, Finland, studied how high - intensity interval training (HIIT) alters the brain's glucose metabolism in physically inactive insulin resistant people.

Endocrinologist Robert Schwartz of the University of Colorado Health Sciences Center in Denver suggests how diet could factor into the equation: calorie restriction — which is known to reduce insulin resistance — might alter metabolism by influencing the types of fat that calories build.

«Our hypothesis was that there is increased prevalence of cerebral microbleeds in MS because progression of that disease is associated with increased likelihood of cardiovascular comorbidities, including hypertension, altered lipid metabolism, overweight / obesity, smoking and diabetes and migraine, all risk factors for cerebral microbleeds,» he said.

Aware that cancers rewire their metabolism in ways that could change the epigenome and that distant metastases in pancreatic cancer naturally spread to organs fed by a sugar - rich blood supply, the researchers wondered if the tumor cells had altered the way they use the basic form of sugar, glucose.

The surgery also changes the community of bacteria living in a patient's gut, which may drive weight loss and could even alter metabolism.

The article «A gestational diet high in fat soluble vitamins alters expression of genes in 1 brain pathways and reduces sucrose preference, but not food intake, in Wistar male rat offspring» by Sanchez - Hernandez et al. was published in the journal Applied Physiology, Nutrition, and Metabolism.

But the terpenes only contribute to the aroma if they are in a free state, as Prof. Wilfried Schwab from TUM's Biotechnology of Natural Products program explains: «Terpenes are biochemically altered in the metabolism of plants — usually through the attachment of sugars, or glycosylation.

MYC also profoundly alters the oscillations of glucose metabolism and perturbs the consumption of glutamine, both essential metabolic molecules for cells.

That research showed that mice on a normal diet who were exposed to low doses of antibiotics throughout life, similar to what occurs in commercial livestock, packed on 10 to 15 percent more fat than untreated mice and had a markedly altered metabolism in their liver.

«This technique has allowed us to identify a number of metabolism - altering drugs that affect seizure susceptibility,» said Dr. Kuebler, «It has opened up a new line of research looking at the effect dietary modifications have on seizure susceptibility.»

New research suggests the bacteria that cause tuberculosis alter their metabolism to combat exposure to antimicrobials, and that these metabolic «escape pathways» might be neutralized by new drugs to shorten the troublesome duration of therapy.

The studies open up new opportunities to uncover microbial genomes from other environments, revealing how microbes alter global carbon and nitrogen cycles, how microbial metabolism evolved, and how so many different kinds of microbes can coexist, says biological oceanographer Paul Falkowski of Rutgers University in New Brunswick, New Jersey.

Research has shown that calorie restriction changes the levels of hormones and lipid metabolites, and alters energy metabolism.

In this schematic of the new «liver on a chip» device, adding blood - sugar - raising glucagon to inlet 1 and blood - sugar - lowering insulin to inlet 2 distributes the hormones across the field of hepatocytes (purple box) along opposing gradients, altering the cells» metabolism from glucose release on the left side to glucose uptake on the right.

Professor of Nutritional Metabolism, Bruce Griffin, said: «Our findings provide new evidence that consuming high amounts of sugar can alter your fat metabolism in ways that could increase your risk of cardiovasculaMetabolism, Bruce Griffin, said: «Our findings provide new evidence that consuming high amounts of sugar can alter your fat metabolism in ways that could increase your risk of cardiovasculametabolism in ways that could increase your risk of cardiovascular disease.

The altered methionine metabolism leads to activation of oncogenes, while the changes in tryptophan metabolism shield GBM cells from detection by immune cells.

The premature surge of leptin may be altering the development of the hypothalamus, a region of the brain that helps to regulate appetite and metabolism, say the researchers, who report their findings today in Cell Mmetabolism, say the researchers, who report their findings today in Cell MetabolismMetabolism.

Exomeres largely fuse with cells in the bone marrow and liver, where they can alter immune function and metabolism of drugs.

Not only were levels of metabolic compounds different, but the expression of certain genes involved in metabolism was turned up, and the epigenome of the cells — molecular markers on DNA that change gene expression on a broader scale — was altered.

Shaw's research focuses on cancer metabolism: how metabolic pathways are altered in cancer and play a role in the origins and progression of the disease.

These results imply that acidified seawater impacts larval physiology, suggesting that suppressed metabolism and metamorphosis may alter the dispersal potential of larvae and subsequently reduce the resilience of coral communities in the near future as the ocean pH decreases.

Lastly, almost all potential gene therapies at the present time aim at best to compensate for the damage of aging in one way or another, or to very modestly slow the progression of that damage by altering the operation of metabolism is ways that are still far from fully mapped.

In mice, the anti-angiogenic mTOR inhibitor everolimus did not alter cognitive functions but led to weight loss and modification of cell metabolism in brain regions involved in sleep / wake cycle or food intake, likely connected to fatigue.

Abdurrachim D, Luiken JJ, Nicolay K, Glatz JF, Prompers JJ, Nabben M. Good and bad consequences of altered fatty acid metabolism in heart failure: evidence from mouse models.

That's for all the same reasons that drug development to alter metabolism to slow aging is a waste of time.

All such globally altered states of metabolism in which aging is slowed require a great deal of time and effort to explore in detail, and that remains a work in progress.

Thus, Haber muses, altered cancer metabolism is not just about energy supply, but also directly affects gene expression through regulating chromatin, and that «closes the loop» between metabolism and genetics — but still poses the chicken - or - the - egg problem of which came first.

Unlike the case of most gene therapies that are intended to permanently alter their target cells, however, Oisín's senoablative genetic constructs will not be inserted permanently into the patient's genome: instead, its genetic payload will be expressed temporarily from the main body of the cell, following which the construct will be passively degraded by normal cellular metabolism.

Interestingly, recent GWASs (45 — 47) have identified SNPs near FADS1 that are associated with conditions of altered metabolism, including f - glucose, dyslipidemia, and circulating sphingolipid levels.

SO WHERE DOES ALTERED METABOLISM RANK as a cause of cancer?

He also contended that this altered metabolism was the cause of cancer, and for decades that notion was at the center of cancer research.

IDH is mutated early in the development of those cancers, supporting the theory that cancer cells evolve toward altered metabolism, «selecting» mutated genes as they develop.

«Maybe the normal versions of oncogenes and tumor suppressors originally evolved to regulate metabolism, and their mutations alter metabolism in ways that inevitably become oncogenic,» says Thompson.