As such,
the altered metabolism in the bone cells caused the mice to have a beneficial whole - body glucose turnover and a lean body.
Helfand speculates that Indy mutations might
alter metabolism in a manner similar to caloric restriction, which extends life - span in mammals and other animals.
That research showed that mice on a normal diet who were exposed to low doses of antibiotics throughout life, similar to what occurs in commercial livestock, packed on 10 to 15 percent more fat than untreated mice and had a markedly
altered metabolism in their liver.
«Maybe the normal versions of oncogenes and tumor suppressors originally evolved to regulate metabolism, and their mutations
alter metabolism in ways that inevitably become oncogenic,» says Thompson.
Cancer cells
alter their metabolism in the interest of sustaining rapid growth, and high levels of PHGDH appear to drive such metabolic change.
Interfering with the way hormones or their receptors are made or controlled (example: by
altering their metabolism in the liver)
Not exact matches
«We found that there are differences
in these microRNA profiles, and that the majority of the
altered microRNAs influence
metabolism,» said Molly Carney, medical student
in the Penn State College of Medicine.
High folic acid consumption leads to pseudo-MTHFR deficiency,
altered lipid
metabolism, and liver injury
in mice.
Carcinogens may cause cancer by
altering cellular
metabolism or damaging DNA directly
in cells, which interferes with normal biological processes.
Furthermore,
in the affected men the researchers observed an
altered secretion of the intestinal hormones glucagon - like peptide - 1 (GLP - 1) and peptide YY (PYY), which contribute to the regulation of the glucose
metabolism or body weight and whose secretion is subject to a particular circadian rhythm.
They studied the bone
metabolism at the cellular level using advanced imaging and computational techniques, which allowed them to identify 142 metabolites that were significantly
altered by more than 1.5 times
in the diabetic mice.
The article «Late - onset Caloric Restriction
Alters Skeletal Muscle
Metabolism by Modulating Pyruvate
Metabolism» is published ahead of print
in the American Journal of Physiology - Endocrinology and
Metabolism.
The panel continues to recommend a three - part therapy that contains AZT, or the HIV inhibitor called TDF,
in the place of stavudine, which can
alter fat
metabolism and cause nerve damage.
Components of indoor dust may signal human fat cells to grow and may
alter metabolism, potentially contributing to weight problems, researchers report July 14
in Environmental Science & Technology.
That finding, the authors say, confirms previous studies that brain
metabolism is «substantially
altered»
in schizophrenia.
«Remarkably, our findings suggest that composition of the gut microbiota influence and
alter central carbon
metabolism in a genotype independent manner.
More work is needed to determine whether the findings on rapamycin hold true
in animal models of Leigh syndrome and other neurodegenerative diseases, and to ascertain how exactly rapamycin is
altering the
metabolism of the cells.
New markers suggested include total mass of hemoglobin,
altered expression of genes related to red blood cell
metabolism, ironomics, storage lesions, and the presence of plasticizers from blood bags
in athlete urine samples.
Researchers at the University of Turku, Finland, studied how high - intensity interval training (HIIT)
alters the brain's glucose
metabolism in physically inactive insulin resistant people.
Endocrinologist Robert Schwartz of the University of Colorado Health Sciences Center
in Denver suggests how diet could factor into the equation: calorie restriction — which is known to reduce insulin resistance — might
alter metabolism by influencing the types of fat that calories build.
«Our hypothesis was that there is increased prevalence of cerebral microbleeds
in MS because progression of that disease is associated with increased likelihood of cardiovascular comorbidities, including hypertension,
altered lipid
metabolism, overweight / obesity, smoking and diabetes and migraine, all risk factors for cerebral microbleeds,» he said.
Aware that cancers rewire their
metabolism in ways that could change the epigenome and that distant metastases
in pancreatic cancer naturally spread to organs fed by a sugar - rich blood supply, the researchers wondered if the tumor cells had
altered the way they use the basic form of sugar, glucose.
Cell Phones
Alter Brain
Metabolism: A 50 - minute phone call boosts metabolism in the brain regions closest to the antenna, including areas involved in language, decision making, and emotional p
Metabolism: A 50 - minute phone call boosts
metabolism in the brain regions closest to the antenna, including areas involved in language, decision making, and emotional p
metabolism in the brain regions closest to the antenna, including areas involved
in language, decision making, and emotional processing.
The surgery also changes the community of bacteria living
in a patient's gut, which may drive weight loss and could even
alter metabolism.
The article «A gestational diet high
in fat soluble vitamins
alters expression of genes
in 1 brain pathways and reduces sucrose preference, but not food intake,
in Wistar male rat offspring» by Sanchez - Hernandez et al. was published
in the journal Applied Physiology, Nutrition, and
Metabolism.
But the terpenes only contribute to the aroma if they are
in a free state, as Prof. Wilfried Schwab from TUM's Biotechnology of Natural Products program explains: «Terpenes are biochemically
altered in the
metabolism of plants — usually through the attachment of sugars, or glycosylation.
Further research showed that the WWOX gene plays a role
in the
altered metabolism of cancer cells which are known to use glucose differently to normal cells.
«Diets that lack fiber
alter the bacterial composition and bacterial
metabolism, which
in turn causes defects to the inner mucus layer and allows bacteria to come close [encroach], something that triggers inflammation and ultimately metabolic disease,» says Hansson.
Researchers
in Brazil have found that mouse skin responds to caloric restriction by stimulating fur growth, increasing blood flow, and
altering cell
metabolism to increase energy efficiency.
Still, he adds, «there's a lot more basic biology that will need to be worked out to fully appreciate the mechanisms that cause sweeteners to
alter gut microbial community composition and function, and how
in turn this shapes host
metabolism.»
The studies open up new opportunities to uncover microbial genomes from other environments, revealing how microbes
alter global carbon and nitrogen cycles, how microbial
metabolism evolved, and how so many different kinds of microbes can coexist, says biological oceanographer Paul Falkowski of Rutgers University
in New Brunswick, New Jersey.
In this schematic of the new «liver on a chip» device, adding blood - sugar - raising glucagon to inlet 1 and blood - sugar - lowering insulin to inlet 2 distributes the hormones across the field of hepatocytes (purple box) along opposing gradients,
altering the cells»
metabolism from glucose release on the left side to glucose uptake on the right.
Professor of Nutritional
Metabolism, Bruce Griffin, said: «Our findings provide new evidence that consuming high amounts of sugar can alter your fat metabolism in ways that could increase your risk of cardiovascula
Metabolism, Bruce Griffin, said: «Our findings provide new evidence that consuming high amounts of sugar can
alter your fat
metabolism in ways that could increase your risk of cardiovascula
metabolism in ways that could increase your risk of cardiovascular disease.
The
altered methionine
metabolism leads to activation of oncogenes, while the changes
in tryptophan
metabolism shield GBM cells from detection by immune cells.
Masoro settled
in at Tufts and spent the next 10 years investigating how low temperature
alters carbohydrate and fat
metabolism in the liver.
The premature surge of leptin may be
altering the development of the hypothalamus, a region of the brain that helps to regulate appetite and
metabolism, say the researchers, who report their findings today in Cell M
metabolism, say the researchers, who report their findings today
in Cell
MetabolismMetabolism.
Exomeres largely fuse with cells
in the bone marrow and liver, where they can
alter immune function and
metabolism of drugs.
Not only were levels of metabolic compounds different, but the expression of certain genes involved
in metabolism was turned up, and the epigenome of the cells — molecular markers on DNA that change gene expression on a broader scale — was
altered.
The research team behind the study, which is being published
in the journal Epigenetics, also found strong links between these
altered epigenetic patterns and the activity
in genes controlling improved
metabolism and inflammation.
Shaw's research focuses on cancer
metabolism: how metabolic pathways are
altered in cancer and play a role
in the origins and progression of the disease.
These results imply that acidified seawater impacts larval physiology, suggesting that suppressed
metabolism and metamorphosis may
alter the dispersal potential of larvae and subsequently reduce the resilience of coral communities
in the near future as the ocean pH decreases.
Lastly, almost all potential gene therapies at the present time aim at best to compensate for the damage of aging
in one way or another, or to very modestly slow the progression of that damage by
altering the operation of
metabolism is ways that are still far from fully mapped.
In mice, the anti-angiogenic mTOR inhibitor everolimus did not alter cognitive functions but led to weight loss and modification of cell metabolism in brain regions involved in sleep / wake cycle or food intake, likely connected to fatigu
In mice, the anti-angiogenic mTOR inhibitor everolimus did not
alter cognitive functions but led to weight loss and modification of cell
metabolism in brain regions involved in sleep / wake cycle or food intake, likely connected to fatigu
in brain regions involved
in sleep / wake cycle or food intake, likely connected to fatigu
in sleep / wake cycle or food intake, likely connected to fatigue.
Abdurrachim D, Luiken JJ, Nicolay K, Glatz JF, Prompers JJ, Nabben M. Good and bad consequences of
altered fatty acid
metabolism in heart failure: evidence from mouse models.
All such globally
altered states of
metabolism in which aging is slowed require a great deal of time and effort to explore
in detail, and that remains a work
in progress.
Over 200 compounds appear to
alter Aβ
metabolism or behavioral deficits
in AD transgenic mice [30] but none have translated into AD therapeutics [98].
We already have, since some approved drugs intervene
in cancer cells» specific metabolic needs, but research into how
altered metabolism promotes cancer is leading to more directed efforts.
IDH is mutated early
in the development of those cancers, supporting the theory that cancer cells evolve toward
altered metabolism, «selecting» mutated genes as they develop.
Langmuir 29 (35), 10973 - 10979 (2013) «Reduced limbic
metabolism and fronto - cortical volume
in rats vulnerable to alcohol addiction» A. Gozzi, F. Agosta, M. Massi, R. Ciccocioppo, and A. Bifone NeuroImage 69, 112 - 119 (2013) «Polymeric nanocarriers for controlled and enhanced delivery of therapeutic agents to the CNS» M. Gagliardi, G. Bardi and A. Bifone Theraputic Delivery, 3 (7), 875 — 887 (2012), doi: 10.4155 / TDE.12.55 «Neuromapping techniques
in drug discovery: pharmacological MRI for the assessment of novel antipsychotics» A. Bifone and A. Gozzi Expert Opinions
in Drug Discovery, 7 (11): 1071 - 82 (2012) «Neuroimaging evidence of
altered fronto - cortical and striatal function after prolonged self - administration
in the rat»
The results suggest that drugs that
alter sarcosine
metabolism might be useful
in treating prostate cancer, but Chinnaiyan cautions that these Petri - dish findings still need further validation
in animal models.