Sentences with phrase «alterations in»

The effects of consuming emulsifiers were eliminated in mice devoid of microbiota (germ - free mice), and transplanting microbiota from emulsifier - treated mice to germ - free mice was sufficient to transfer alterations in intestinal epithelial cells» homeostasis, suggesting a central role played by the microbiota in tumor development.

This study demonstrated that emulsifier - induced alterations in the microbiome were necessary and sufficient to drive alterations in intestinal epithelial cells» homeostasis, which is thought to govern tumor development.

Although epigenetic changes are usually temporary, they involve alterations in the proteins that bind together the long strands of DNA.

First, mild endoplasmic reticulum stress and impaired calcium release seriously disturbed mitochondrial dynamics, thus providing an explanation as to why alterations in the endoplasmic reticulum could lead to impaired mitochondrial dynamics.

«Key genetic event underlying fin - to - limb evolution: Study of catsharks reveals how alterations in the expression, function of certain genes in limb buds underlie evolution of fish fins to limbs.»

For example, there are indications that Alzheimer's may be associated with decreased connectivity; depression with increased connectivity; epilepsy with disruptions in connectivity and Parkinson's with alterations in connectivity.

Gilad speculates that the relatively rapid alterations in human liver genetics might be the result of ongoing changes in diet, such as growing reliance on cooked food.

In fact, the genetic mouse model deficient in Cdk2, which was reported 12 years ago by Mariano Barbacid's group at CNIO, is also viable but sterile and shows the exact same alterations in meiosis as those observed by the researchers at IRB Barcelona.

Although therapies tailored based on genetic alterations in these tumors have been developed, their benefit is usually short - lived.

An international group of scientists led by the University of Granada (UGR) has demonstrated that the long - term intake of sunflower or fish oils damages the liver and can cause a series of alterations in it, giving rise to non-alcoholic steatohepatitis (NASH).

While both males and females with autism had alterations in regions of the corpus callosum connected to the frontal lobe, the pattern of alterations differed between the sexes.

«Significant impacts to the lake could result from incidental or accidental spills from 5,100 ships passing through every year; invasive species brought by transoceanic ships, which could threaten the extinction of aquatic plants and fish, such as the cichlids that have been evolving since the lake's formation; and frequent dredging, impacting aquatic life through alterations in turbidity and hypoxia, triggered by resuspension of nutrients and organic matter that exert a relatively high biochemical oxygen demand.»

Telomere dysfunction — alterations in the structure and / or functioning of telomeres — is one of the molecular mechanisms underlying a number of age - related diseases but, to date, little is known about its possible role in pathologies of the liver such as cirrhosis, hepatitis and liver cancer.

This is usually naturally corrected as they grow up, he says, but in some people, the sight of an amputee at a very young age may have reinforce the alterations in the brain.

The treated rodents were not only fatter but also suffered elevated levels of fasting insulin, and alterations in genes related to liver regeneration and detoxification — effects consistent with metabolic disorders in obese patients.

The researchers found that mice with gastric acid suppression developed alterations in their gut microbiomes.

Research from Rutgers Cancer Institute of New Jersey examining difficult to treat cancer tumors through genomic profiling shows that tumors with alterations in a signaling pathway responsible for cell regulation may respond to targeted therapy regardless of where the tumor originated in the body.

In summary, sterile triploid salmon show potential for use in the Norwegian salmon farming industry although they are likely to require alterations in culture practices to achieve their greatest potential.

Telomeres are DNA regions at the ends of our chromosomes that protect the genetic data of cells, preventing mutations and alterations in the DNA that could potentially cause disease.

«This study shows that we can use ctDNA in the bloodstream to identify patients who acquire these targetable alterations in the metastases.

One of the main challenges in finding a treatment for the disease in the future is the research and development of pharmacological therapies capable of activating the Crtc1 protein, with the aim of preventing, slowing down or reverting cognitive alterations in patients.

While the finding does not directly lead to a test for immunotherapy response yet, Choueiri said, «We intend to look at these specific genomic alterations in larger, randomized controlled trials, and we hope that one day these findings will be the impetus for prospective clinical trials based on these alterations.»

Alterations in the genetic coding for a nerve cell receptor, which detects a chemical signal that is key to behavioral change, could point the way to designing therapies most effective for patients suffering from schizophrenia, drug addiction and other mental illnesses.

Give these scientists, who have proven that they can think outside the box and inside the womb, the opportunity and wherewithal to design a couple of comprehensive, multi-organ assays to detect the most sensitive alterations in embryonic and fetal development and function.

Methylation is one type of so - called epigenetic changes, alterations in genes during the lifetime that affect their expression.

One of the reasons for this is the lack of knowledge on the cellular mechanisms which cause alterations in nerve transmissions and the loss of memory in the initial stages of the disease.

More recently, brain scans have directly linked these conditions with changes in levels of neurotransmitters — chemicals that convey messages across neurons — or alterations in the number or structure of neurons in different brain areas.

Alterations in air and sea temperatures could lower fog frequency, for instance.

But how do alterations in RNA splicing result in hearing loss?

As part of an ongoing clinical trial at Rutgers Cancer Institute exploring rare and poor prognosis cancers, investigators sought to identify genomic alterations in 69 patients with gynecologic cancers that were not responding to standard care.

In human children, alterations in anxiety levels could impact learning in school or test scores, although existing evidence is not so fine - grained.

«As we have now shown, even brief exposure to IL - 6 can lead to long - lasting alterations in colon cancer cells that enhance their mobility and thus increase their metastasizing potential,» says Heiko Hermeking of LMU's Institute of Pathology.

One of the mechanisms driving alterations in gene expression is epigenetic change, where the female is able to change her offspring's genome to cause certain genes to be expressed differently.

The toy company Hasbro did make some interesting alterations in its Nerf lineup — its Nerf Vortex football has a tail, for example, which improves the distance it travels when thrown.

It demonstrates that alterations in these cells lines do indeed match changes in samples of human bladder cancer.

In the Yerkes and Mount Sinai study, the research team sought to determine whether non-surgical exposure to sevoflurane, an inhaled anesthetic commonly used with children, could lead to cognitive and behavioral alterations in a nonhuman primate (NHP) model.

Our study helps to understand the link between genetic susceptibility and microbial alterations in the gut in IBD,» explained lead investigator André Bleich, PhD, Professor and Director, Institute for Laboratory Animal Science, Hannover Medical School, Hannover (Germany).

While alterations in DNA are not proven to cause cancer, he says, «additional data from animals would not have hurt before this decision was made»

When exposed to small alterations in acidity or temperature, for instance, they can dramatically transform their appearance and size.

In 1954 molecular biologist Anthony C. Alison had surmised that alterations in the hemoglobin molecule protected against death from malaria.

In all, the study found and validated 76 alterations in cancer - associated genes in the cell lines, many of which are involved in activating known oncogenes including TERT, TP53 and PIK3CA.

In other words, alterations in the number of chromosomes, which can lead to a tumour process,» explains Montoya.

Alterations in the quantity of atmospheric greenhouse gases determines the amount of solar energy retained by the planet, leading to global warming or global cooling.

Stroud concludes, «These alterations in stress hormones, stress response, and DNA may explain links between moms» smoking during pregnancy and the risk for their children to have behavior problems and nicotine addiction in later life.

The ɛ4 allele has also been linked to the severity of hippocampal atrophy and pathological alterations in the neocortex.

In addition, effects of smoking during pregnancy on infant cortisol and stress response were explained by alterations in DNA for a gene that regulates passage of cortisol from mother to fetus.

The DNA methylation revealed a much stronger link to survival than all other previously studied alterations in individual DNA building blocks (SNPs, single nucleotide polymorphisms).

After babies were born, placentas were collected and DNA was analyzed for alterations in the glucocorticoid receptor.

Neurologically, the primary features seen most often and most evidently in infants were alterations in motor activity, reflected in body tone, posture and motility or movement; severe hypertonia (abnormal muscle tension and contraction); abnormal neurobehaviors, such as poor or delayed response to visual stimuli, and excitability.

«Most previous studies have focused on using one technique at a time, even though we have evidence that there are alterations in the brain in autism in terms of structure, white - matter connectivity, and brain chemical concentrations.