Not exact matches
Using clinical, genetic, and
gene expression data
as filters to distinguish
genes whose copy number
alteration causes cancer from those for whom copy number changes are incidental, the team whittled down their list from 14,000 to a more manageable number, each of which they systematically tested using genetic experiments
in animals.
Gene moonlighting can occur merely through changes
in expression, which may result from
as little
as a single mutation; it does not require the meandering process of random
alteration and selection implied by the duplication and neofunctionalization model.
This observation is further supported by the fact that studying
alterations in the
expression of
genes also made it possible to identify persons whose levels of interleukin 6, an inflammation marker, were reduced
as their serum vitamin D levels increased.
Compared with the ancestral lineage, the East African cichlid genomes possess: an excess of
gene duplications;
alterations in regulatory, non-protein-coding elements
in the genome; accelerated evolution of protein - coding elements, especially
in genes for pigmentation; and other distinct features that affect
gene expression, such
as insertions of transposable elements and regulation by novel microRNAs.
Because DDX3 exhibits tumor suppressor functions, such
as a growth - suppressive property and transcriptional activation of the p21waf1 / cip1 promoter, and is inactivated through down - regulation of
gene expression or
alteration of subcellular localization
in tumor cells, all these features together suggest that DDX3 might be a candidate tumor suppressor.
Gene expression Reporter genes, such as luciferase or GFP, can also be assessed in microplate readers, enabling in vitro and in vivo determination of gene expression for studies using markers of genetic alterat
Gene expression Reporter
genes, such
as luciferase or GFP, can also be assessed
in microplate readers, enabling
in vitro and
in vivo determination of
gene expression for studies using markers of genetic alterat
gene expression for studies using markers of genetic
alteration.
Changes
in an epigenetic mechanism that turns
expression of
genes on and off may be
as important
as genetic
alterations in causing pediatric acute lymphoblastic leukemia (ALL), according to a study led by scientists at St. Jude Children's Research Hospital and published
in the June 10 online edition of the Journal of Clinical Investigation.
We examine
alterations in biological stress regulatory systems;
alterations in the neural regulation of stress responses; and
expression of
genes related to stress responses, both
as latent indicators of impending health risks and
as indicators of psychological and biological stress - reactive processes that may accelerate those risks.