Sentences with phrase «altered cellular metabolism»

Carcinogens may cause cancer by altering cellular metabolism or damaging DNA directly in cells, which interferes with normal biological processes.

Not exact matches

They studied the bone metabolism at the cellular level using advanced imaging and computational techniques, which allowed them to identify 142 metabolites that were significantly altered by more than 1.5 times in the diabetic mice.

Unlike the case of most gene therapies that are intended to permanently alter their target cells, however, Oisín's senoablative genetic constructs will not be inserted permanently into the patient's genome: instead, its genetic payload will be expressed temporarily from the main body of the cell, following which the construct will be passively degraded by normal cellular metabolism.

Aβ is believed to penetrate neuronal plasma membranes, where it leads to lipid peroxidation.10 It has also been implicated in deactivating a subunit of the pyruvate dehydrogenase complex, thereby inhibiting conversion of pyruvate to acetyl CoA and the eventual production of cellular energy as ATP.32 Another way Aβ affects glucose metabolism in the brain is that fragments of Aβ disrupt insulin signaling by binding to neuronal synapses, which alters their shape and function.15, 38 Insulin receptors are abundant at synapses, so if the integrity of the synapse itself has been compromised, the receptors won't function effectively.

The selenium issue is further complicated because the synthetic antioxidants still used in some foods to protect fats from rancidity can impair the bioavailability of vitamin A, vitamin E and selenium, and alter cellular membrane function, metabolism and detoxification.