Sentences with phrase «altered expression»

His research focuses on understanding how bacteria adapt to changes in their environment by altering the expression of their genes.

In fact, five of the 100 most stable genes have altered expression levels in liver cancer.

Prior research studies have concluded that the chemical directly alters the expression of our genes to lower the risk from many different types of cancer.

The finding offers some of the strongest evidence yet that a mother's environment during pregnancy can alter the expression of DNA in ways that are passed on to future generations.

Our findings are consistent with other studies also reporting elevated levels of oxidative stress markers in the eyes of POAG patients, along with altered expression of antioxidant defenses in the TM.

The team identified thousands of genes with altered expression patterns after light exposure, and 611 genes that had at least two-fold increases or decreases.

For the first time, scientists have improved how a crop uses water by 25 percent without compromising yield by altering the expression of one gene that is found in all plants, as reported in Nature Communications.

While the findings demonstrate how altering the expression of a single key gene can make a big difference to brain development, a future challenge will be to obtain a comprehensive, integrated view of all the molecular changes that made our brains big.

These studies provide evidence that HDAC may serve as an important molecular mediator within the epigenome, thereby altering expression of synaptic plasticity - associated genes during alcoholism.»

Among the study findings, IR mutations alter expression of many genes both in fibroblasts and iPSCs compared to normal cells, «but the impact is very much dependent on the cell type,» says Kahn.

While changes in the expression of several hundred genes were detected by microarray analyses, in the study by D'Mello and colleagues over 4,000 genes displayed significantly altered expression.

This line provided the basis for altering the expression of Pax6 in the cortical stem cell lineage such that it would be sustained in basal progenitors.

The article «A gestational diet high in fat soluble vitamins alters expression of genes in 1 brain pathways and reduces sucrose preference, but not food intake, in Wistar male rat offspring» by Sanchez - Hernandez et al. was published in the journal Applied Physiology, Nutrition, and Metabolism.

In their new paper, Shi and colleagues report that reactivation of cocaine memories in rats alters the expression of a protein that releases lactate from glia and enables nerve cells to take up lactate.

Our functional studies revealed that the variants alter expression of SP110 in blood cells continues Sergey Kozyrev, senior scientist at Uppsala University.

Transcriptional activation of retrotransposons alters the expression of adjacent genes in the wheat.

These datasets will allow the characterization of how genetically different parasites that cause distinct types of human toxoplasmosis alter the expression of protein - encoding and miRNA - encoding genes in both the human host and the parasite.

Gene duplicates may rapidly adopt altered expression patterns.

There are also four independent intergenic shufflons that potentially alter the expression and function of varied genes.

To evaluate whether altered expression of the ABL genes is associated with breast cancer progression and metastasis, we examined the expression of ABL1 and ABL2 in normal and invasive breast tumor specimens using published TCGA (The Cancer Genome Atlas) data sets (14 — 16).

The researchers in this study investigated whether a high - fat, high - caloric meal altered the expression of sirtuins in humans.

Surprisingly, they did this without altering the expression of genes thought to be involved with the calcification process.

The two - step process of TILT — getting sick upon toxicant exposure and failing to get well — may be driven by epigenetic changes, which occur when the environment alters the expression of genes without changing the core DNA code itself.

They determined that altering the expression level of LIGHT (a specific type of molecule that binds to a receptor site of another cell) and also lymphotoxin (LT) on T cells significantly impacted the cholesterol and triglyceride levels.

• Changes in the size of snail kites» beaks can be explained by altered expression of existing genes — through «phenotypic plasticity» (2 December 2017, p 7).

Ramadan fasting in Saudi Arabia is associated with altered expression of CLOCK, DUSP and IL - 1alpha genes, as well as changes in cardiometabolic risk factors.

Our goal is to gain mechanistic understanding how altered expression or function of key mitotic regulators (e.g. GTPases, kinases) can give rise to genetically unbalanced cells that may initiate tumorigenesis.

(With DNA methylation, a methyl group — one carbon atom and three hydrogen atoms — attaches to a gene, thereby altering its expression.)

She concludes that finding drugs to alter the expression of these genes could mitigate the effects of oxidative stress, treating some symptoms of Down's prenatally.

Now, it turns out, horses also use the muscles underlying their facial features — eyes, nostrils, and lips — to alter their expressions, scientists report today in PLOS ONE.

«Margery's experiments showed that the NS1 protein can alter expression of Hedgehog target genes on its own, without other viral proteins,» said Bier, professor and newly named holder of the Tata Chancellor's Endowed Professorship in Cell and Developmental Biology.

New markers suggested include total mass of hemoglobin, altered expression of genes related to red blood cell metabolism, ironomics, storage lesions, and the presence of plasticizers from blood bags in athlete urine samples.

And we suspect that these life experiences can alter the expression of genes, and as a result, affect an animal's susceptibility to stress,» says senior author Bruce McEwen, Alfred E. Mirsky Professor and head of the Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology.

These products are designed to alter the expression of target genes in the body, suppressing expression of genes associated with disease, or restoring expression of genes required for health.

And we've been able to demonstrate that the altered expression of those particular genes actually mediate the symptoms seen.

Most of the genes that have altered expression are in the cerebellum.

«We found that 5 to 10 percent of these chromosome modifications were different in children born through assisted reproduction, and this altered the expression of nearby genes,» Sapienza says.

His hope is to identify and possibly block the altered expression that may be causing the improper neural development.

That, in turn, alters the expression of genes that without the medications would cause cancer cells to proliferate.

«Consuming the phytochemical p - coumaric acid, which is ubiquitous in beebread and honey, alters the expression of a whole suite of genes involved in caste determination,» said University of Illinois entomology professor and department head May Berenbaum, who conducted the study with research scientist Wenfu Mao and cell and developmental biology professor Mary Schuler.

These could alter the expression of genes on other chromosomes, and might be partly responsible for behavioural differences between the sexes, says Rissman.

The group found that neurons derived from patients with schizophrenia formed fewer connections with one another than those derived from healthy patients; they also linked the deficit to the altered expression of nearly 600 genes, four times as many as had been previously implicated.

This altered expression that does not correlate with changes in the base sequence is known as epigenetic regulation (as opposed to genetic regulation).

Over 100 of the genes also had altered expression and many of these could contribute to reduced insulin production.