Sentences with phrase «altered gene expression»

Hulmi et al. [87] found that 21 weeks of supplementing 15 g of whey before and after resistance training increased size and altered gene expression favorably towards muscle anabolism in the vastus lateralis.

The metals also altered gene expression, perturbed hormonal balance and accelerated the proliferation of the breast cancer cells.14

Unless healthy gut flora is reestablished in early infancy, the child may suffer permanently altered gene expression and altered behavior; and may be prone to vaccine damage.

These features were related to a modified gene expression pattern in adult male testes, showing an altered gene expression in genes involved in DNA repair and apoptosis that was confirmed by TUNEL assay.

Here, we report that suboptimal IVC altered the gene expression of adult male testis and induced apoptosis.

But transcriptome studies also have significant limitations, such an inability to determine reverse causality — whether gene expression levels are altered by disease, or whether disease arises due to altered gene expression.

In some cases, the jump altered gene expression in a way that influenced the stem cells» fate — making them more likely to turn into neurons, for example.

The underlying genetic basis of many of these differences may be altered gene expression.

It also remains unclear how knocking down expression of certain genes in zygotes via sperm miRNA leads to altered stress response in adult animals and altered gene expression in the brain.

The altered gene expression may have led to slower - growing kidney tumours.

The researchers discovered that this receptor mutation profoundly altered gene expression in neurons receiving dopamine at distal sites in the brain, specifically in the prefrontal cortex.

The male offspring of mothers fed the high - fat diet showed altered gene expression in the hippocampus which persisted through adulthood.

Monitoring mRNA could tell scientists a great deal about which genes are being expressed in a cell, and tweaking the translation of mRNA would allow them to alter gene expression without having to modify the cell's DNA.

However, microgravity can reduce cell growth, alter gene expression and change the pattern of root growth — all aspects which critically affect plant cultivation in space.

Surprisingly, RNAs in these various guises shut down and otherwise alter gene expression.

Others have tracked the first few hours of the embryonic development of sea urchins and other organisms with the goal of seeing how various transcription factors alter gene expression over time.

The work, published online this week in the journal Nature, suggests modulation of «enhancer - directed RNAs» or «eRNAs» could provide a new way to alter gene expression in living cells, perhaps affecting the development or pathology of many diseases.

«Because many broadly expressed genes that play key roles in essential cellular functions are under the control of cell - specific enhancers, the ability to affect enhancer function by knocking down eRNAs could potentially provide a new strategy for altering gene expression in vivo in a cell - specific manner,» said Glass, noting that in his research, anti-sense oligonucleotides were developed in conjunction with Isis Pharmaceuticals, which suppressed enhancer activity and reduced expression in nearby genes.

ONC201 may inhibit cancer stem cell self - renewals by altering their gene expression, according to a study published August 2, 2017 in the open - access journal PLOS ONE by Varun Vijay Prabhu from Oncoceutics, Inc., USA and colleagues.

They found that ONC201 alters the gene expression of cancer stem cell markers and signaling pathways prior to killing the tumor cells, providing pharmacodynamic biomarkers of response.

«Enhancer RNAs alter gene expression: New class of molecules may be key emerging «enhancer therapy».»

And in 2012, they uncovered the first evidence that sleep apnea influences epigenetics, altering gene expression without changing an individual's DNA.

«This is the first example of how early environment can alter gene expression without mutating the gene itself,» Jirtle says.

Furthermore, besides offering valuable insight into the function of this novel RNA type, the researchers also believe that the findings will open new avenues for novel treatments in which cell - specific enhancer sequences can be targeted to alter gene expression.

These changes, made through a process called DNA methylation, alter gene expression.

Hutchinson - Gilford progeria is caused by a spontaneous mutation during conception in a gene called LMNA, which encodes a protein called prelamin A. Progeria patients experience a buildup of an abnormal version of prelamin A in their cells that, among other changes, distorts the nucleus and alters gene expression.

Beebread contains p - coumaric acid, which alters gene expression and contributes to the honey bees» developmental fate.

The study examined DNA methylation — an «annotation» of DNA that alters gene expression without changing the genomic sequence itself — in a group of diverse Latino children.

Fluid forces can cause cultured cardiac cells to alter gene expression patterns and rearrange their cytoskeleton.

Therapeutic drugs can also be made to fit these pockets, switching the nuclear receptor on or off to alter gene expression.

DNA methylation alters gene expression.

Laboratory diet profoundly alters gene expression and confounds genomic analysis in mouse liver and lung.

The researchers also showed just how flexible their LITE system could be by applying it to altering gene expression via epigenetics with the addition of histone modifiers.

Epigenetic modification is certainly not the only CRISPR - based technology designed to alter gene expression.

In cancer, mutations occur in a cell's DNA sequence that alter gene expression and cause uncontrolled cell growth.

I would like to research how chromatin modulation alters gene expression during early stages of differentiation using computational biology and experimental approaches.

Alter the structure of the chromatin and you alter gene expression.

Her current research is focused on discovering how normal and disease melanocyte cell states establish distinct regulatory DNA landscapes, and also determining how the combination of both genetic variation within these regulatory regions and environmental cell signals alter gene expression and normal cell function.

In addition, a small pilot study of 20 sibling pairs with extremely dissimilar problem behavior will investigate whether environments alter gene expression.

The Notch system thus allows cells to receive signals from their neighbors and alter their gene expression accordingly.

Isis develops RNA drugs based on its antisense technology, which inhibits or alters gene expression.

Alter Gene Expression.

A small Norwegian study suggested that yoga's many healthy benefits might come from its ability to alter gene expression in immune cells.

One potential explanation for a reduced inflammatory response is that regular yoga practice may alter gene expression and protein synthesis.

In fact, the beneficial bacteria strains in milk kefir actually repopulate the digestive tract, whereas the cultures added to yogurt work more behind the scenes to positively alter gene expression and reduce inflammation.

The protein, ATF4, is a transcription factor that alters gene expression in skeletal muscle, causing reduction of muscle protein synthesis, strength, and mass.

Beta - carotene has been shown to boost immunity, alter gene expression (which could potentially protect us against cancer and autoimmune disease), and even strengthen the intestinal lining to protect against infection.

✓ Alter gene expression.

Creating an awareness of your mind - breath connection can help to: reduce stress and anxiety, lower blood pressure, enhance creativity, improve heart rate variability, and even alter your gene expression.

Early Experiences Can Alter Gene Expression and Affect Long - Term Development: Working Paper No. 10.