Sentences with phrase «altered gene functions»

It studies altered gene functions that are not due to a change in the DNA sequence, but may nevertheless be inherited.

Genetic variation can take the form of common base changes (polymorphisms) that alter gene function or rare base changes (mutations) that often have highly deleterious effects.

«Rare variants alter gene function but occur at low frequency in a population.

«Shifting protein networks in breast cancer may alter gene function: Changes in gene function in tumor samples correlate with patient survival.»

In addition, the DHA and EPA found in fish oil have a powerful ability to enhance the metabolism and increase fat burning by positively altering the gene functioning through various mechanisms which include changing the makeup of cell membranes, altering the transcription of genes and influencing the levels of calcium within the cells.

Not exact matches

We're funding researchers to investigate how drugs alter what genes are activated such that they modify the function of the cells, and how this, in turn, modifies the functions of brain circuits, and how that modifies behavior.

Because the prion - forming protein identified in the study normally functions as a regulator of gene activity, the researchers say their discovery raises the possibility that when it switches to a prion state, it could alter genetic expression and bacterial behavior.

Although the function of the gene isn't fully established, it is thought to add sugars to proteins, which could alter the speed or specificity of their usual function.

However, resistance to therapy might go beyond cancer mutations that usually alter the function of genes.

Our life experiences exert a profound influence on how we age and can even alter the ways genes function without changing the underlying DNA sequence; these genetic changes are called epigenetic traits.

«We have shown that the synthesis of nitric oxide (NO), known to regulate gut motility functions and NRF2, a transcriptional factor known to regulate several antioxidant genes, mediated Phase II protein expression have been altered in colon specimens of polybacterialinfected ApoE - / - mice,» said Miriam Walker.

«Because many broadly expressed genes that play key roles in essential cellular functions are under the control of cell - specific enhancers, the ability to affect enhancer function by knocking down eRNAs could potentially provide a new strategy for altering gene expression in vivo in a cell - specific manner,» said Glass, noting that in his research, anti-sense oligonucleotides were developed in conjunction with Isis Pharmaceuticals, which suppressed enhancer activity and reduced expression in nearby genes.

Furthermore, besides offering valuable insight into the function of this novel RNA type, the researchers also believe that the findings will open new avenues for novel treatments in which cell - specific enhancer sequences can be targeted to alter gene expression.

Most of those mutations are probably benign, but some may alter a protein's structure and function, or interfere with gene activity, leading to disease.

RNA interference (RNAi), an effective tool to assess gene function in many organisms, is largely ineffective in apicomplexans, while random mutagenesis is difficult to interpret because the altered gene is difficult to identify.

The agency decided the mushroom was not subject to regulations on genetically modified organisms (GMOs) because, unlike previous genetic engineering techniques, gene editing does not insert foreign DNA from viruses or bacteria to alter a plant's function.

«Estrogen alters memory circuit function in women with gene variant: Hormone - gene interaction may underlie sex / individual differences in mental disorders.»

So far, scientists have found that different populations of living humans have inherited the Neandertal version of genes that cause diabetes, lupus, and Crohn's disease; alter immune function; and affect the function of the protein keratin in skin, nails, and hair.

They identified combinations of genes whose altered activities contributed to desirable traits; the functions of some of these genes were previously unknown, demonstrating the technique's ability to generate new biological knowledge.

Then they sorted the mutations by type, focusing on 15,259 nonsynonymous mutations, which alter amino acids and thus a gene's function.

We report that a synonymous SNP in the Multidrug Resistance 1 (MDR1) gene, part of a haplotype previously linked to altered function of the MDR1 gene product P - glycoprotein (P - gp), nonetheless results in P - gp with altered drug and inhibitor interactions.

For now, Stadler's team wants to focus on the regions in which it found altered gene numbers to see how the CNVs affect gene and protein functions.

Evidence suggests that estrogenic compounds appear to alter the ability of genes to function properly, a phenomenon referred to as epigenetic changes.

When the research team used pharmaceuticals to inhibit one function of the endoplasmic reticulum (the building of so - called lipoprotein particles that will export fats out of the cell), the gene activation process was inhibited for many key genes and nuclear ruffling was also altered.

For biologists in the laboratory, this is a way to probe a geneâ $ ™ s function by making an animal with its genes altered in a certain way.

They also want to be able to insert more subtle mutations, such as those reported in HIV - resistant individuals, which could alter cell function just enough to confer resistance but without fully deactivating the gene and impeding cell function.

Frequently insertions / deletions alter the open reading frame (ORF) of the target gene, disrupting the gene function downstream of the DSB.

However, this cellular intervention alters the normal expression of hypophosphorylated retinoblastoma (RB) protein needed for the expression of genes involved in cell functions [3] and, therefore, results in an abnormal cell.

Only introducing the altered gene into cells and studying protein function in the lab provides that information, Traynelis says.

The epigenome functions like a set of switches for regulating gene expression and can be altered by environmental conditions.

There are also four independent intergenic shufflons that potentially alter the expression and function of varied genes.

They then identified damaging mutations in the children that would disable the protein produced by a particular gene or alter the protein's function.

2 - Demonstrate how the physiological function of the DHPR and of RYR1 is altered by specific disease mutations of their encoding genes.

Rather than modify protein structure and function, these noncoding variants frequently impact regulatory elements and thereby alter the quantitative and spatiotemporal regulation of gene expression.

Many HARs are located near genes that control fundamental developmental processes, 9 so their altered regulatory function could have profound effects on human biology.

We hypothesize that loss of MLL3 / KMT2C function leads to a shift in the enhancer landscape, altering the sites available for estrogen receptor binding and thus changing gene transcription in breast cancer.

First, Dr. Shendure described some interesting experiments under way in his lab to elucidate the function of non-coding regulatory variants — specifically, single nucleotide changes in the core promoter that alter gene transcription.

It is tempting to speculate that these mutations destroy or change gene regulatory functions, altering when and where genes turn on.

Her current research is focused on discovering how normal and disease melanocyte cell states establish distinct regulatory DNA landscapes, and also determining how the combination of both genetic variation within these regulatory regions and environmental cell signals alter gene expression and normal cell function.

We are also examining how gene expression and mitochondrial function is altered in human cells in the disorder known as Chronic Fatigue Syndrome or Myalgic Encephalomyelitis, in order to develop objective tests for the illness as well to identify causal factors.

New genes include WNT7B, which in all probability can lead to an altered kidney function in freshwater fish, as the salt balance between the fish and the surrounding water has to function.

These tumor suppressor genes are two of the most frequently altered genes in human cancer, and understanding how they function at the molecular level will both refine our fundamental understanding of this disease and suggest novel therapeutic approaches to treat it.

Polymorphisms in five of 15 genes (33 %) encoding molecules known to primarily influence pancreatic beta - cell function - ABCC8 (sulphonylurea receptor), KCNJ11 (KIR6.2), SLC2A2 (GLUT2), HNF4A (HNF4alpha), and INS (insulin)- significantly altered disease risk, and in three genes, the risk allele, haplotype, or both had a biologically consistent effect on a relevant physiological trait in the QT study.

We estimate that 42 % of our cohort carry pathogenic DNMs in coding sequences; approximately half of these DNMs disrupt gene function and the remainder result in altered protein function.

This dichotomy points out the importance of an indirect influence on proteins whose altered function is required during carcinogenesis but are too essential to be mutated (i.e., mutation of their encoding genes could decrease the viability of cancer cells).

It is mentioned that certain types of exercise can alter the way genes function and interact with your cells.

AAEM pointed to numerous animal studies that showed oxidative stress, altered structure and function of the liver, intestinal damage, disruption of the immune system, increased cell growth and hundreds of alterations in gene expressions.

Studies in animals have shown that changes in diet can alter the function of genes — known as epigenetic change.

Others occur in genes and alter the function of a gene in a harmful way causing disease (e.g. PRA).

There is also the possibility of a genetic cause involving the p53 gene and an Rb gene which normally act as tumor suppresser genes and for some reason are altered preventing their usual functioning.