This has been evidenced by 1) increased acinar
cell necrosis, 2) increased serum amylase and lipase, 3) higher hepatic damage, 4)
altered liver function test, 5) increased
kidney damage, 6) increase in serum urea and creatinine, 7)
altered distribution of pancreatic
cells, 8) increased vacoulation and irregular islets, and 9) mild fibrosis in exocrine regions.
Our biological studies suggest that a critically reduced amount of this protein
alters cell shape, migration, proliferation, and gene expression to the detriment of brain, heart, and
kidney development.