There's no need to turn on the oven or grill — the acidity of the lemon and lime juice
alters the proteins in the seafood, cooking it without heat.
Thus, virtually every pharmaceutical on the market today is either a protein itself or a type of molecule that
alters protein function.
Rare variations, by contrast, are more likely to
alter protein expression or function and therefore have a direct or causal association with a disease.
It's by no means simple, but we have the strong starting point of understanding that variants in coding sequences likely
alter protein sequence and / or structure.
Proteins are the part of the food that triggers an allergic reaction and some people believe that cooking a
food alters the protein enough so that your child won't be allergic to it anymore.
Altering the protein recycling complexes in human cells, including cancer cells, allows the cells to resist treatment with a class of drugs known as proteasome inhibitors, according to Whitehead Institute scientists.
Sometimes, however, those
changes alter the protein in such a way that it becomes a useful toxin — and voilà, a venom toxin is born.
Engelen, M. P., Rutten, E. P., De Castro, C. L., Wouters, E. F., Schols, A. M., and Deutz, N. E. Supplementation of soy protein with branched - chain amino
acids alters protein metabolism in healthy elderly and even more in patients with chronic obstructive pulmonary disease.
I think it is most appropriate to borrow the words from someone far smarter and well versed on this topic here (Dr. Kevin Hall), «A logical consequence of the carbohydrate - insulin model is that decreasing the proportion of dietary carbohydrate to fat
without altering protein or calories will reduce insulin secretion, increase fat mobilization from adipose tissue, and elevate oxidation of circulating free fatty acids.
Using a technique called proteomics to
examine altered protein levels in muscle cells in mice, the team identified an enzyme protein called neutrophil elastase that was found to be more abundant in dystrophic muscle as compared to healthy muscle.
Because many of the
mutations alter protein sequences and other biologically meaningful targets, they should be monitored for impact on diagnostics, vaccines, and therapies critical to outbreak response.
German physician Aloysius «Alois» Alzheimer (left) first described the disease that would bear his name after
finding altered proteins in the brain of his patient Auguste Deter (right).
Experimenting with human cells and mice, Johns Hopkins researchers have found that a genetic mutation that
alters a protein called NOD1 may increase susceptibility to human cytomegalovirus (CMV) infection.
Dr Christos Gkogkas, a Chancellor's Fellow in the University of Edinburgh's Centre for Discovery Brain Sciences, said: «Our study reveals that
altered protein synthesis through eIF4E is a key cellular process in the brain that can go awry in depression.
The most common approach is to focus on protein - truncating variants or PTVs (sometimes also called loss - of - function variants *) that terminate or
substantially alter the protein sequence.
Four TRPM4 Cation Channel Mutations Found in Cardiac Conduction Diseases Lead to Altered Protein Stability
Team finds that some cells activate only one of their two gene copies during development,
altering protein yields and raising new questions...
«The homogenisation and pasteurisation process
actually alters the protein structure of cow's milk, making it a lot harder to digest,» Clark says.
In a recent article E Magazine pointed out that popular holistic health expert Dr. Andrew Weil has written, «There may be dangers associated with microwaving food... there is a question as to whether
microwaving alters protein chemistry in ways that might be harmful.»
Dog food
manufacturers alter the protein molecules of their ingredients to make them smaller and more digestible to your pup's body, without setting off his immune system.
Hydrolyzed dog food
uses alters proteins (reduces the weight) in a way that makes them easier to digest.
They sell variety of theirs original Balinese coffee products, herb oil and etc and see the civet cat the most expensive coffee maker, wellknown as Luwak, its produce «Coffee Luwak» and the process of the bean passing through the digestive tract of the civet
chemically alters the proteins in the Luwak coffee bean to yield more complex and smooth flavors, not found in conventional coffees.
CAMBRIDGE, Mass. —
Altering the protein recycling complexes in human cells, including cancer cells, allows the cells to resist treatment with a class of drugs known as proteasome inhibitors, according to Whitehead Institute scientists.
The researchers also found evidence of extensive RNA editing, which allows the octopus to
alter protein sequences without changing underlying DNA code.
«With 100 million mutations, each capable of
altering a protein in some way, there is a high probability that a significant minority of tumor cells will survive, even after aggressive treatment,» said study director Chung - I Wu, PhD, professor of ecology and evolution at the University of Chicago.
The altered protein may be an adaptation that helps the animals drift into hibernation.
But she says it's too early to predict how
the altered protein will behave in people.
The larger scale Cancer Genome Atlas study provided the information needed to
alter proteins or RNA sequences that may act as «drivers» for prognostic biomarkers or therapeutic targets.
«The fact that the genetic code can simultaneously write two kinds of information means that many DNA changes that appear to
alter protein sequences may actually cause disease by disrupting gene control programs or even both mechanisms simultaneously,» said Stamatoyannopoulos.
«When cells are stressed, for example when nutrient levels are low,
they alter protein production as a survival strategy.
Altering proteins in one part of the virus to achieve a certain benefit, such as more efficient gene transfer or reduced recognition by host immune cells, could end up destroying the structural integrity of the entire shell.
«These adaptations include unique amino - acid - sequence substitutions that are predicted to
alter protein function, protein - sequence divergence, and positive natural selection,» Cavener said.
They searched across more than 220,000 genetic variants that
altered proteins to identify those that appeared to influence heart disease risk.
Mutations occur in DNA that are then transcribed into RNA; the RNA is then translated into
an altered protein.
And while
the altered protein also contributed to the growth of already - present tumors, it did not trigger the spontaneous development of new tumors.
(And imagine the ramifications if
the altered proteins are transcription factors that activate the genes coding for still other transcription factors!)
Most of those mutations are probably benign, but some may
alter a protein's structure and function, or interfere with gene activity, leading to disease.
When the researchers tested
the altered proteins by mixing them with IgE taken from people allergic to cashews, about 50 % fewer of the IgE bound to the altered proteins compared with when they mixed the IgE with unmodified cashew proteins, they report today at the 248th National Meeting & Exposition of the American Chemical Society in San Francisco, California, and in the 16 July issue of the Journal of Agricultural and Food Chemistry.
By identifying
the altered proteins that enable the virus to infect humans, it could focus the efforts of vaccinemakers on those proteins and speed development of a SARS vaccine, she says.