Sentences with phrase «altered the protein activity»

Scientists Find Small Changes in an Antibody Binding Site Can Completely Alter Protein Activity

Researchers altered the protein activity in a developing chicken's face.

Not exact matches

Perlmann, who was born in Czechoslovakia but later became a U.S. citizen, was one of the first to recognize the importance of phosphate groups in the structure of many proteins; she showed that phosphates added to or stripped from a protein can dramatically alter its activity.

The short answer is proteins and pieces of RNA that alter gene activity within cells.

Because the prion - forming protein identified in the study normally functions as a regulator of gene activity, the researchers say their discovery raises the possibility that when it switches to a prion state, it could alter genetic expression and bacterial behavior.

Treatments for Huntington's have typically focused on blocking the activity of the mutant HTT protein, the assumption being that the altered form of the protein was more active than normal, and therefore toxic to neurons.

RPM - 1 uses PPM - 2, an enzyme that removes a phosphate group from a protein thereby altering its function, in combination with ubiquitin ligase activity to directly inhibit DLK - 1.

The good news is that WWOX belongs to a family of proteins that have enzyme activity - this means WWOX activity can be altered by targeting the enzyme.

Most of those mutations are probably benign, but some may alter a protein's structure and function, or interfere with gene activity, leading to disease.

«The recruitment of distinct protein complexes at the non-prion and prion - like forms to create altered activity states indicates the prion - like behavior is in essence a protein conformation - based switch.

SUMOylation occurs when an enzyme attaches a molecular tag called a Small Ubiquitin - like Modifier (SUMO) to a protein, altering its activity and location in the cell.

Target - based strategies typically employ in vitro high - throughput screening methods to identify small molecules that alter the activity of an identified candidate protein implicated in a disease process.

Once the bacterial cell signaling protein cagA reaches the host cytosol, it is capable of altering subsequent generations of progenitor cells, leading to the development of cancer through changes in mitotic activity, apoptosis, cellular assembly, and signaling.26 Although it should be noted that while the presence of the cagA protein doubles the risk of gastric cancer, cagA - negative strands also increase the risk of distal gastric cancer.27 Additional H pylori virulence factors include babA2, which encodes bacterial adhesion with gastric epithelial cells, and vacuolating cytotoxin A, which is encoded by the gene vacA.28, 29 H pylori strains carrying some combination of the babA2, cagA, and vacA genes were associated with the highest risk of developing intestinal metaplasia.

For example, it modulates enzymatic activity, induces structural changes in proteins and nucleic acids, alters kinetics of molecular bonds, regulates motion of molecular motors, and has a role in mechanical transduction and sensory functions.

This text covers topics ranging from plant genome structure and the key control points in how genes are expressed, to the mechanisms by which proteins are generated and how their activities are controlled and altered by posttranslational modifications.

A single poor transcript could therefore have devastating consequences, not just by directly altering a cell's enzymatic activity but through a domino effect that leaves other, unrelated proteins unable to function right.

Typically, these green fluorescent proteins are used to monitor the activity of altered genes.

In the different cell types of the body, different protein producing genes are active or inactive, and many medical conditions also depend on altered activity of specific genes.

Small molecule a low molecular weight (usually less than 500 Daltons) organic compound that can bind to and alter the activity or function of proteins, nucleic acids, or polysaccharides.

The variant appears to alter the activity of MTDH / AEG -1 in cells, which regulates the activity of the EAAT2 gene: the EAAT2 protein is responsible for clearing glutamate from brain synapses in the brain....

However, although this adaptation allows survival it has secondary effects, because the increased lifetimes of proteins increase the probability of their undergoing undesirable chemical modifications, such as oxidation, glycation and cross-linking, which can alter their activities.