Sentences with phrase «altering coding sequence»
A significant proportion of SVs affect known protein - coding genes by altering coding sequence or gene dose.
http://massgenomics.org/
Synonymous single - nucleotide polymorphisms (SNPs) do not produce altered coding sequences, and therefore they are not expected to change the function of the protein in which they occur.
Not exact matches
«The fact that the genetic code can simultaneously write two kinds of information means that many DNA changes that appear to alter protein sequences may actually cause disease by disrupting gene control programs or even both mechanisms simultaneously,» said Stamatoyannopoulos.
DNA methylation and other epigenetic alterations — chemical changes to DNA that can alter a gene's expression without affecting its protein - coding sequence — may underlie some of the lasting biochemical havoc, Ghanei says.
The presence of such sequences could provide organisms with a way to modify their gene expression without altering the actual coding sequence of genes.
The researchers also found evidence of extensive RNA editing, which allows the octopus to alter protein sequences without changing underlying DNA code.
We estimate that 42 % of our cohort carry pathogenic DNMs in coding sequences; approximately half of these DNMs disrupt gene function and the remainder result in altered protein function.