Sentences with phrase «altering gene sequences»

The toxin did not appear to be altering gene sequences; instead, Skinner and colleagues found, vinclozolin was somehow causing other chemical groups to latch onto certain genes, changing their expression (Science, 3 June 2005, p. 1391).

Not exact matches

Using Atlantic killifish (Fundulus heteroclitus), the researchers examined whether mitochondrial - nuclear interactions alter the frequency of alternative forms of a gene that arise by mutation, called alleles, for over 11,000 nuclear DNA sequence variations within a population of the fish with mixed ancestry.

In the new study, the researchers sequenced the entire genome of mice that had undergone CRISPR gene editing in the team's previous study and looked for all mutations, including those that only altered a single nucleotide.

CRISPR - Cas9 is a versatile and highly accurate gene - editing technology that allows researchers to modify specific parts of an organism's genome by altering sections of the DNA sequence.

It studies altered gene functions that are not due to a change in the DNA sequence, but may nevertheless be inherited.

Stress is thought to cause «epigenetic» changes to genes, which do not alter the sequence of their DNA but instead leave chemical marks that dictate how active genes are.

«By inserting the new sequence into the DNA, perhaps they are altering the gene in some other way,» he says.

A new study suggests that epigenetic effects — chemical modifications of the human genome that alter gene activity without changing the DNA sequence — may sometimes influence sexual orientation.

«The fact that the genetic code can simultaneously write two kinds of information means that many DNA changes that appear to alter protein sequences may actually cause disease by disrupting gene control programs or even both mechanisms simultaneously,» said Stamatoyannopoulos.

Our life experiences exert a profound influence on how we age and can even alter the ways genes function without changing the underlying DNA sequence; these genetic changes are called epigenetic traits.

A gene may be hundreds or thousands of letters long, and if a mutation alters some part of the sequence, a disease may ensue.

Epigenetic changes do not alter the information encoded in the DNA sequence itself but determine whether and to what extent specific genes are used by cells.

In vitro experiments and high - throughput RNA sequencing revealed that CTCF deletion profoundly altered the B lymphocyte transcriptional program, shifting cells from a gene expression profile typical of the germinal center to one more similar to that seen in plasma cells.

Epigenetics refers to reversible modifications to DNA that don't affect the DNA sequence but alter how genes are read.

They identified 24 previously unknown epigenetic changes that alter a woman's risk of breast cancer and can be passed down through generations without involving changes in the DNA sequence of genes.

Furthermore, besides offering valuable insight into the function of this novel RNA type, the researchers also believe that the findings will open new avenues for novel treatments in which cell - specific enhancer sequences can be targeted to alter gene expression.

DNA methylation and other epigenetic alterations — chemical changes to DNA that can alter a gene's expression without affecting its protein - coding sequence — may underlie some of the lasting biochemical havoc, Ghanei says.

A series of genetic analyses confirmed that the DNA target sequence had been altered in the transgenic plants, with either DNA insertions or deletions in both copies of the DFR - B gene (so - called bi-allellic mutants).

In recent years, CRISPR, a sequence of DNA, has become best known for its use in gene editing, when scientists alter or delete DNA in living organisms.

The study examined DNA methylation — an «annotation» of DNA that alters gene expression without changing the genomic sequence itself — in a group of diverse Latino children.

It will potentially eliminate the need to sequence around a newly discovered disease SNP to find the variant that actually alters the gene product, says NHGRI Director Francis Collins.

An individual's gene sequence is determined at conception, but the external environment and an individual's lifestyle can change the epigenetic sequence throughout a lifetime, continually altering how genes are expressed.

Immunizing drives could block the spread of unwanted gene drives by preemptively altering target sequences.

It turns out that iPS cells and embryonic stem cells have differing patterns of methylation, a modification of DNA that can alter how genes behave even if the underlying DNA sequence remains the same.

First, the researchers analyze sequence data from an individual's tumor and identify four to 10 genes altered in the cells.

For this compilation, I've emphasized publications in which whole - genome or exome sequencing was employed to multiple tumors or cancer cell lines, with the goal of identifying significantly altered genes or pathways in malignant cells.

PULLMAN — Researchers at Washington State University have identified a new class of DNA sequence variation in gene promoter regions that could help control the activity of genes.The novel variations, dubbed «multiple nucleotide length polymorphisms,» or MNLPs, altered transcription of the genes they were associated with as much as 11-fold.

The presence of such sequences could provide organisms with a way to modify their gene expression without altering the actual coding sequence of genes.

A novel study from researchers at Karolinska Institutet shows that by using so called random sequence labels, working as barcodes for tracing genetically altered cells, during CRISPR / Cas9 gene knock - outs it is possible to generate more comprehensive data from a smaller number of cells.

In cancer, mutations occur in a cell's DNA sequence that alter gene expression and cause uncontrolled cell growth.

Zoghbi's lab also found that this altered ATXN1 gene sequence encodes a bulky, improperly folded protein that is toxic to brain cells.

Epigenetics refers to factors that change gene behavior without altering the DNA sequence.

In this study, using whole - genome DNA sequencing (WGS) and confirmation by Sanger sequencing, we observed mutations identified in several genes not previously known to be recurrently altered in SMZL.

A significant proportion of SVs affect known protein - coding genes by altering coding sequence or gene dose.

We estimate that 42 % of our cohort carry pathogenic DNMs in coding sequences; approximately half of these DNMs disrupt gene function and the remainder result in altered protein function.

The term has evolved to include any process that alters gene activity without changing the DNA sequence, and leads to modifications that can be transmitted to daughter cells.