Sentences with phrase «altering gene transcription»

Melanocytes respond by altering gene transcription, and these changes in gene expression profiles result in easily quantifiable phenotypes such as modified pigment production (a hallmark of melanocyte differentiation state) and changes in morphological cell properties.

First, Dr. Shendure described some interesting experiments under way in his lab to elucidate the function of non-coding regulatory variants — specifically, single nucleotide changes in the core promoter that alter gene transcription.

Not exact matches

As in any good marriage, moreover, the attachment of the methyl groups significantly altered the behavior of whichever gene they wed, inhibiting its transcription, much like a jealous spouse.

Vitamin A and vitamin D are precursors to hormones that influence biological processes by entering the nucleus of a cell, binding to DNA, and altering the transcription of certain genes.

Others have tracked the first few hours of the embryonic development of sea urchins and other organisms with the goal of seeing how various transcription factors alter gene expression over time.

PRMT5 (protein arginine methyltransferase 5) is an enzyme that alters the structure of chromatin to suppress the transcription of genes and the production of proteins.

Of 17 regulatory variants identified in the two genes with regulatory variant burden, we show that at least six alter transcription factor - DNA binding in human neuroblastoma cells.

A famous example of how transcription factor expression can be used to alter a cell's identity is the creation of iPSCs, where adult cells were forced to express transcription factors normally expressed in ESCs, which made the adult cells express genes specific to ESCs, and consequently become nearly identical to ESCs.

The novel variations, dubbed «multiple nucleotide length polymorphisms,» or MNLPs, altered transcription of the genes they were associated with as much as 11-fold.

Diana Hargreaves studies a particular epigenetic regulator, the SWI / SNF complex, which uses energy to unpack and unwind DNA from structural proteins to alter DNA accessibility and in turn, gene transcription.

PULLMAN — Researchers at Washington State University have identified a new class of DNA sequence variation in gene promoter regions that could help control the activity of genes.The novel variations, dubbed «multiple nucleotide length polymorphisms,» or MNLPs, altered transcription of the genes they were associated with as much as 11-fold.

We hypothesize that loss of MLL3 / KMT2C function leads to a shift in the enhancer landscape, altering the sites available for estrogen receptor binding and thus changing gene transcription in breast cancer.

However, it is unclear whether this enhanced interaction selectively facilitates transcription of specific p53 target genes, including sestrins, or whether p53 serine18 phosphorylation also regulates specific target genes by altering interactions of p53 with other coactivators such as chromatin modifying enzymes.

These findings provide new insights into how chromatin regulation modulates stochastic gene expression and transcriptional bursting, with implications for regulation of pluripotency and development.Polycomb repressive complexes modify histones but it is unclear how changes in chromatin states alter kinetics of transcription.

Results: Within 4 h, activation of CD4 (+) T cells invokes changes in histone modifications and enhancer RNA transcription that correspond to altered expression of the interacting genes identified by promoter capture Hi - C.

In addition, the DHA and EPA found in fish oil have a powerful ability to enhance the metabolism and increase fat burning by positively altering the gene functioning through various mechanisms which include changing the makeup of cell membranes, altering the transcription of genes and influencing the levels of calcium within the cells.

The protein, ATF4, is a transcription factor that alters gene expression in skeletal muscle, causing reduction of muscle protein synthesis, strength, and mass.

The transcription factor nerve growth factor - inducible protein a mediates epigenetic programming: Altering epigenetic marks by immediate - early genes