Sentences with phrase «altering the expression of»

In animal models, exposure to cigarette smoke or nicotine during fetal development alters the expression of the nicotinic acetylcholine receptor in areas of the brainstem important for autonomic function, 28 alters the neuronal excitability of neurons in the nucleus tractus solitarius (a brainstem region important for sensory integration), 29 and alters fetal autonomic activity and medullary neurotransmitter receptors.30 In human infants, there are strong associations between nicotinic acetylcholine receptor and serotonin receptors in the brainstem during development.31 Prenatal exposure to tobacco smoke attenuates recovery from hypoxia in preterm infants, 32 decreases heart rate variability in preterm33 and term34 infants, and abolishes the normal relationship between heart rate and gestational age at birth.33 Moreover, infants of smoking mothers exhibit impaired arousal patterns to trigeminal stimulation in proportion to urinary cotinine levels.35 It is important to note also that prenatal exposure to tobacco smoke alters the normal programming of cardiovascular reflexes such that there is a greater - than - expected increase in blood pressure and heart rate in response to breathing 4 % carbon dioxide or a 60 ° head - up tilt.36 These changes in autonomic function, arousal, and cardiovascular reflexes might all increase an infant's vulnerability to SIDS.

She concludes that finding drugs to alter the expression of these genes could mitigate the effects of oxidative stress, treating some symptoms of Down's prenatally.

The two - step process of TILT — getting sick upon toxicant exposure and failing to get well — may be driven by epigenetic changes, which occur when the environment alters the expression of genes without changing the core DNA code itself.

«Margery's experiments showed that the NS1 protein can alter expression of Hedgehog target genes on its own, without other viral proteins,» said Bier, professor and newly named holder of the Tata Chancellor's Endowed Professorship in Cell and Developmental Biology.

New markers suggested include total mass of hemoglobin, altered expression of genes related to red blood cell metabolism, ironomics, storage lesions, and the presence of plasticizers from blood bags in athlete urine samples.

And we suspect that these life experiences can alter the expression of genes, and as a result, affect an animal's susceptibility to stress,» says senior author Bruce McEwen, Alfred E. Mirsky Professor and head of the Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology.

These products are designed to alter the expression of target genes in the body, suppressing expression of genes associated with disease, or restoring expression of genes required for health.

And we've been able to demonstrate that the altered expression of those particular genes actually mediate the symptoms seen.

For the first time, scientists have improved how a crop uses water by 25 percent without compromising yield by altering the expression of one gene that is found in all plants, as reported in Nature Communications.

The article «A gestational diet high in fat soluble vitamins alters expression of genes in 1 brain pathways and reduces sucrose preference, but not food intake, in Wistar male rat offspring» by Sanchez - Hernandez et al. was published in the journal Applied Physiology, Nutrition, and Metabolism.

In their new paper, Shi and colleagues report that reactivation of cocaine memories in rats alters the expression of a protein that releases lactate from glia and enables nerve cells to take up lactate.

Our functional studies revealed that the variants alter expression of SP110 in blood cells continues Sergey Kozyrev, senior scientist at Uppsala University.

These could alter the expression of genes on other chromosomes, and might be partly responsible for behavioural differences between the sexes, says Rissman.

The virus essentially acts like a «sponge», preventing MSI1 from working correctly and altering the expression of many genes involved in neuronal development.

Changes in DNA methylation in brain cells has been an extremely active research area since these epigenetic changes were shown to alter the expression of genes needed to form and maintain long - term memories.

These datasets will allow the characterization of how genetically different parasites that cause distinct types of human toxoplasmosis alter the expression of protein - encoding and miRNA - encoding genes in both the human host and the parasite.

Mycoplasma compete with host cells for nutrients and can alter expression of receptors, ion channels, and growth factors resulting in changes to the cell line's growth and behavior.

Among the study findings, IR mutations alter expression of many genes both in fibroblasts and iPSCs compared to normal cells, «but the impact is very much dependent on the cell type,» says Kahn.

Loss of Vascular Endothelial Growth Factor A (VEGFA) Isoforms in the Testes of Male Mice Causes Subfertility, Reduces Sperm Numbers, and Alters Expression of Genes That Regulate Undifferentiated Spermatogonia.

Lauritzen F, Perez EL, Melillo ER, Roh JM, Zaveri HP, Lee TS, Wang Y, Bergersen LH, Eid T (2012) Altered expression of brain monocarboxylate transporter 1 in models of temporal lobe epilepsy Neurobiol Dis, 45 (1), 165 - 76 PubMed 21856423

To evaluate whether altered expression of the ABL genes is associated with breast cancer progression and metastasis, we examined the expression of ABL1 and ABL2 in normal and invasive breast tumor specimens using published TCGA (The Cancer Genome Atlas) data sets (14 — 16).

The altered expression of CCNA1 is similar to the expression of EIF1AX, another marker for zygotic genomic activation in our study as well as in a previous animal study [32].

IL - 6 can induce osteoclast activation indirectly by altering the expression of RANKL and OPG in osteoblasts (51).

Using genomics approaches, Dr. Nobrega has identified the gene IRX3 as the strongest association to polygenic obesity in humans, and characterized the mechanisms by which mutations altering the expression of a gene called TCF7L2 also represent the strongest genetic link to type 2 diabetes in humans.

Our findings are consistent with other studies also reporting elevated levels of oxidative stress markers in the eyes of POAG patients, along with altered expression of antioxidant defenses in the TM.

Insertion of the kan marker into ospC is unlikely to alter expression of adjacent genes, because they are well isolated and divergently transcribed (Fig. 1).

The activated AHR / NuRD complex altered the expression of differentiation - specific genes that control the first two developmental decisions without affecting the pluripotency program.

If such seemingly transient changes persist, they may alter the expression of genes needed to ward off cancer and other diseases.

Results: Within 4 h, activation of CD4 (+) T cells invokes changes in histone modifications and enhancer RNA transcription that correspond to altered expression of the interacting genes identified by promoter capture Hi - C.

We also demonstrate that ACTB haploinsufficiency leads to reduced cell proliferation, altered expression of cell - cycle genes, and decreased amounts of nuclear, but not cytoplasmic, β - actin.

Furthermore, stated Dr. Malaspina, «our hypothesis and model right now for how paternal age affects the risk for schizophrenia is that it has altered the expression of genes inherited from the father.

«We are able to alter the expression of our genes through a variety of lifestyle factors.

HHV - 6A, but not HHV - 6B nor HHV - 7, altered expression of several microRNAs in a pattern that is considered a marker for patients with autoimmune thyroid disease.

The researchers in this study investigated whether a high - fat, high - caloric meal altered the expression of sirtuins in humans.

Prior research studies have concluded that the chemical directly alters the expression of our genes to lower the risk from many different types of cancer.

Here's what you get during those minutes, according to new reports: an instant endorphin surge and drop in blood pressure, regulation of hunger hormones that may help you keep weight off, and key vitamin D synthesis that alters the expression of 291 genes responsible for everything from controlling how quickly your bones age to how fast you bounce back from tough workouts to how fertile you are.

Variation in genetic background may alter expression of the disease allele in affected animals, thus accounting for variation in phenotypic expression of the disease.

Surprisingly, they did this without altering the expression of genes thought to be involved with the calcification process.

In addition, the conference will examine the possibility that modifying patterns of family interaction may alter the expression of genes linked to health and illness

Although an interaction was established between the type of care (institutional vs. family) and genetic moderation factors, with a protective factor of the 5HTT / allele genotype for high scores on attachment disorganisation in institutionalized children, the authors noted that it is not clear if genetic factors can protect some children in adverse environments or if the experience of being raised in these environments can alter the expression of the gene.

Not exact matches

Taking note of the altered world - consciousness of human beings in this century, according to which Being is to be understood in strictly interpersonal terms, Mühlen suggests, first of all, that the classical expression homoousios, as applied to the Son's relationship to the Father, does not necessarily mean that the Son is of the same substance as the Father but only that he is of equal being (gleichseiendlich) with the Father (VG 13).

First, an adult cell would be removed from a patient and the DNA of that cell altered to control and direct the types of gene expression the nucleus is capable of supporting.

This double - mindedness is difficult to speak of because it approximates both the one and the other, and because it alters itself continually, changing so swiftly that it may have transformed itself several times before the talk had hardly finished describing a single expression.

Throughout his life, he never altered his views on the basic structure of the discipline: its twin tasks (historical and theoretical); the centrality of religious experience and its threefold expressions (theoretical, practical, and sociological); and the crucial importance of hermeneutics.

As the Nazis willfully altered the meaning of German words for ideological reasons, and the Soviet Communists altered the meaning of Russian words (or coined expressions like «former persons) for ideological reasons, so too the advocates of assisted suicide want to banish words like «suicide» and «killing» from discussions of the subject in order to gain an ideological advantage, and same - sex «marriage» advocates want to change the meaning of «marriage» for ideological reasons.

Our understanding of sex in the narrower sense of genital activity and in the wider sense of relationship with others has been so altered in recent years that the assumed fixity of thought in this area, with reference to auto - erotism, homo - erotism, and hetero - erotism, along with the related fixity which has been traditionally accepted in respect to judgements upon the right or wrong ways of sexual expression, has been shown to be indefensible by any intelligent standards.

Merleau - Ponty helps us to see the links between feeling, meaning, and expression; by implication he alters our understanding of symbolic truth.

In what follows we will examine how Whitehead's theory of symbolic reference alters our understanding of the arts, and we will supplement his account with ideas derived from Merleau - Ponty's theory of expression.

Music may even help strengthen premature babies, alters the facial expressions, relaxed body tone and a cessation of crying.

The next step for him and his colleagues is to investigate further why the expression of the SHIP gene is altered in Crohn's disease.