Sentences with phrase «altering their metabolism in»

As such, the altered metabolism in the bone cells caused the mice to have a beneficial whole - body glucose turnover and a lean body.

Helfand speculates that Indy mutations might alter metabolism in a manner similar to caloric restriction, which extends life - span in mammals and other animals.

That research showed that mice on a normal diet who were exposed to low doses of antibiotics throughout life, similar to what occurs in commercial livestock, packed on 10 to 15 percent more fat than untreated mice and had a markedly altered metabolism in their liver.

«Maybe the normal versions of oncogenes and tumor suppressors originally evolved to regulate metabolism, and their mutations alter metabolism in ways that inevitably become oncogenic,» says Thompson.

Cancer cells alter their metabolism in the interest of sustaining rapid growth, and high levels of PHGDH appear to drive such metabolic change.

Interfering with the way hormones or their receptors are made or controlled (example: by altering their metabolism in the liver)

Not exact matches

«We found that there are differences in these microRNA profiles, and that the majority of the altered microRNAs influence metabolism,» said Molly Carney, medical student in the Penn State College of Medicine.

High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice.

Carcinogens may cause cancer by altering cellular metabolism or damaging DNA directly in cells, which interferes with normal biological processes.

Furthermore, in the affected men the researchers observed an altered secretion of the intestinal hormones glucagon - like peptide - 1 (GLP - 1) and peptide YY (PYY), which contribute to the regulation of the glucose metabolism or body weight and whose secretion is subject to a particular circadian rhythm.

They studied the bone metabolism at the cellular level using advanced imaging and computational techniques, which allowed them to identify 142 metabolites that were significantly altered by more than 1.5 times in the diabetic mice.

The article «Late - onset Caloric Restriction Alters Skeletal Muscle Metabolism by Modulating Pyruvate Metabolism» is published ahead of print in the American Journal of Physiology - Endocrinology and Metabolism.

The panel continues to recommend a three - part therapy that contains AZT, or the HIV inhibitor called TDF, in the place of stavudine, which can alter fat metabolism and cause nerve damage.

Components of indoor dust may signal human fat cells to grow and may alter metabolism, potentially contributing to weight problems, researchers report July 14 in Environmental Science & Technology.

That finding, the authors say, confirms previous studies that brain metabolism is «substantially altered» in schizophrenia.

«Remarkably, our findings suggest that composition of the gut microbiota influence and alter central carbon metabolism in a genotype independent manner.

More work is needed to determine whether the findings on rapamycin hold true in animal models of Leigh syndrome and other neurodegenerative diseases, and to ascertain how exactly rapamycin is altering the metabolism of the cells.

New markers suggested include total mass of hemoglobin, altered expression of genes related to red blood cell metabolism, ironomics, storage lesions, and the presence of plasticizers from blood bags in athlete urine samples.

Researchers at the University of Turku, Finland, studied how high - intensity interval training (HIIT) alters the brain's glucose metabolism in physically inactive insulin resistant people.

Endocrinologist Robert Schwartz of the University of Colorado Health Sciences Center in Denver suggests how diet could factor into the equation: calorie restriction — which is known to reduce insulin resistance — might alter metabolism by influencing the types of fat that calories build.

«Our hypothesis was that there is increased prevalence of cerebral microbleeds in MS because progression of that disease is associated with increased likelihood of cardiovascular comorbidities, including hypertension, altered lipid metabolism, overweight / obesity, smoking and diabetes and migraine, all risk factors for cerebral microbleeds,» he said.

Aware that cancers rewire their metabolism in ways that could change the epigenome and that distant metastases in pancreatic cancer naturally spread to organs fed by a sugar - rich blood supply, the researchers wondered if the tumor cells had altered the way they use the basic form of sugar, glucose.

Cell Phones Alter Brain Metabolism: A 50 - minute phone call boosts metabolism in the brain regions closest to the antenna, including areas involved in language, decision making, and emotional pMetabolism: A 50 - minute phone call boosts metabolism in the brain regions closest to the antenna, including areas involved in language, decision making, and emotional pmetabolism in the brain regions closest to the antenna, including areas involved in language, decision making, and emotional processing.

The surgery also changes the community of bacteria living in a patient's gut, which may drive weight loss and could even alter metabolism.

The article «A gestational diet high in fat soluble vitamins alters expression of genes in 1 brain pathways and reduces sucrose preference, but not food intake, in Wistar male rat offspring» by Sanchez - Hernandez et al. was published in the journal Applied Physiology, Nutrition, and Metabolism.

But the terpenes only contribute to the aroma if they are in a free state, as Prof. Wilfried Schwab from TUM's Biotechnology of Natural Products program explains: «Terpenes are biochemically altered in the metabolism of plants — usually through the attachment of sugars, or glycosylation.

Further research showed that the WWOX gene plays a role in the altered metabolism of cancer cells which are known to use glucose differently to normal cells.

«Diets that lack fiber alter the bacterial composition and bacterial metabolism, which in turn causes defects to the inner mucus layer and allows bacteria to come close [encroach], something that triggers inflammation and ultimately metabolic disease,» says Hansson.

Researchers in Brazil have found that mouse skin responds to caloric restriction by stimulating fur growth, increasing blood flow, and altering cell metabolism to increase energy efficiency.

Still, he adds, «there's a lot more basic biology that will need to be worked out to fully appreciate the mechanisms that cause sweeteners to alter gut microbial community composition and function, and how in turn this shapes host metabolism.»

The studies open up new opportunities to uncover microbial genomes from other environments, revealing how microbes alter global carbon and nitrogen cycles, how microbial metabolism evolved, and how so many different kinds of microbes can coexist, says biological oceanographer Paul Falkowski of Rutgers University in New Brunswick, New Jersey.

In this schematic of the new «liver on a chip» device, adding blood - sugar - raising glucagon to inlet 1 and blood - sugar - lowering insulin to inlet 2 distributes the hormones across the field of hepatocytes (purple box) along opposing gradients, altering the cells» metabolism from glucose release on the left side to glucose uptake on the right.

Professor of Nutritional Metabolism, Bruce Griffin, said: «Our findings provide new evidence that consuming high amounts of sugar can alter your fat metabolism in ways that could increase your risk of cardiovasculaMetabolism, Bruce Griffin, said: «Our findings provide new evidence that consuming high amounts of sugar can alter your fat metabolism in ways that could increase your risk of cardiovasculametabolism in ways that could increase your risk of cardiovascular disease.

The altered methionine metabolism leads to activation of oncogenes, while the changes in tryptophan metabolism shield GBM cells from detection by immune cells.

Masoro settled in at Tufts and spent the next 10 years investigating how low temperature alters carbohydrate and fat metabolism in the liver.

The premature surge of leptin may be altering the development of the hypothalamus, a region of the brain that helps to regulate appetite and metabolism, say the researchers, who report their findings today in Cell Mmetabolism, say the researchers, who report their findings today in Cell MetabolismMetabolism.

Exomeres largely fuse with cells in the bone marrow and liver, where they can alter immune function and metabolism of drugs.

Not only were levels of metabolic compounds different, but the expression of certain genes involved in metabolism was turned up, and the epigenome of the cells — molecular markers on DNA that change gene expression on a broader scale — was altered.

The research team behind the study, which is being published in the journal Epigenetics, also found strong links between these altered epigenetic patterns and the activity in genes controlling improved metabolism and inflammation.

Shaw's research focuses on cancer metabolism: how metabolic pathways are altered in cancer and play a role in the origins and progression of the disease.

These results imply that acidified seawater impacts larval physiology, suggesting that suppressed metabolism and metamorphosis may alter the dispersal potential of larvae and subsequently reduce the resilience of coral communities in the near future as the ocean pH decreases.

Lastly, almost all potential gene therapies at the present time aim at best to compensate for the damage of aging in one way or another, or to very modestly slow the progression of that damage by altering the operation of metabolism is ways that are still far from fully mapped.

In mice, the anti-angiogenic mTOR inhibitor everolimus did not alter cognitive functions but led to weight loss and modification of cell metabolism in brain regions involved in sleep / wake cycle or food intake, likely connected to fatiguIn mice, the anti-angiogenic mTOR inhibitor everolimus did not alter cognitive functions but led to weight loss and modification of cell metabolism in brain regions involved in sleep / wake cycle or food intake, likely connected to fatiguin brain regions involved in sleep / wake cycle or food intake, likely connected to fatiguin sleep / wake cycle or food intake, likely connected to fatigue.

Abdurrachim D, Luiken JJ, Nicolay K, Glatz JF, Prompers JJ, Nabben M. Good and bad consequences of altered fatty acid metabolism in heart failure: evidence from mouse models.

All such globally altered states of metabolism in which aging is slowed require a great deal of time and effort to explore in detail, and that remains a work in progress.

Over 200 compounds appear to alter Aβ metabolism or behavioral deficits in AD transgenic mice [30] but none have translated into AD therapeutics [98].

We already have, since some approved drugs intervene in cancer cells» specific metabolic needs, but research into how altered metabolism promotes cancer is leading to more directed efforts.

IDH is mutated early in the development of those cancers, supporting the theory that cancer cells evolve toward altered metabolism, «selecting» mutated genes as they develop.

Langmuir 29 (35), 10973 - 10979 (2013) «Reduced limbic metabolism and fronto - cortical volume in rats vulnerable to alcohol addiction» A. Gozzi, F. Agosta, M. Massi, R. Ciccocioppo, and A. Bifone NeuroImage 69, 112 - 119 (2013) «Polymeric nanocarriers for controlled and enhanced delivery of therapeutic agents to the CNS» M. Gagliardi, G. Bardi and A. Bifone Theraputic Delivery, 3 (7), 875 — 887 (2012), doi: 10.4155 / TDE.12.55 «Neuromapping techniques in drug discovery: pharmacological MRI for the assessment of novel antipsychotics» A. Bifone and A. Gozzi Expert Opinions in Drug Discovery, 7 (11): 1071 - 82 (2012) «Neuroimaging evidence of altered fronto - cortical and striatal function after prolonged self - administration in the rat»

The results suggest that drugs that alter sarcosine metabolism might be useful in treating prostate cancer, but Chinnaiyan cautions that these Petri - dish findings still need further validation in animal models.