Sentences with phrase «alters a protein called»

Experimenting with human cells and mice, Johns Hopkins researchers have found that a genetic mutation that alters a protein called NOD1 may increase susceptibility to human cytomegalovirus (CMV) infection.

Not exact matches

The OAR proposal uses a variation of therapeutic cloning called altered nuclear transfer (ANT) in which the nucleus of a donor cell (a skin cell, for example), containing the 30,000 genes of the genetic code, is altered in such a way that it produces an epigenetic factor, a protein called nanog.

In altering the recipe, I added garbanzo beans for protein (the original recipe calls for chicken) and switched out the chicken broth with vegetable broth.

Its competitors — designer proteins called zinc finger nucleases and TALENs — also precisely alter chosen DNA sequences, and several companies are already exploiting them for therapeutic purposes in clinical trials.

The research suggests that reducing production of the protein, called myoferlin, affects cancer cells in two primary ways: by changing the activation of many genes involved in metastasis in favor of normal cell behavior, and by altering mechanical properties of cancer cells — including their shape and ability to invade — so they are more likely to remain nested together rather than breaking away to travel to other tissues.

The team found that individuals with long - standing type 1 diabetes and diabetic enteropathy have altered colonic stem cells (CoSCs) and increased blood levels of a regulatory protein called insulin - like growth factor binding protein 3 (IGFBP3), which is produced in the liver.

However, the team was able to show that so - called tight junction proteins, which are known to be important for the blood - brain barrier permeability, did undergo structural changes and had altered levels of expression in the absence of bacteria.

Hutchinson - Gilford progeria is caused by a spontaneous mutation during conception in a gene called LMNA, which encodes a protein called prelamin A. Progeria patients experience a buildup of an abnormal version of prelamin A in their cells that, among other changes, distorts the nucleus and alters gene expression.

SUMOylation occurs when an enzyme attaches a molecular tag called a Small Ubiquitin - like Modifier (SUMO) to a protein, altering its activity and location in the cell.

Enzymes in this family couple other proteins in the cell to a molecule called ubiquitin, a step that can alter the function or stability of these target proteins.

Previously, True and Whitehead Institute Director Susan Lindquist reported that a particular yeast protein called Sup35 somehow altered the metabolic properties — or phenotype — of the cell when it «misfolded» into a prion state.

The most common approach is to focus on protein - truncating variants or PTVs (sometimes also called loss - of - function variants *) that terminate or substantially alter the protein sequence.

In the search for compounds that might alter a protein's behavior or function — such as that of alpha - synuclein — drug companies often rely on so - called target - based screens that test the effect large numbers of compounds have on the protein in question in rapid, automated fashion.

The mutation that causes Huntington's Disease alters instructions for building a protein called huntingtin.

Also studied were cells taken from tail arteries of mice genetically altered to no longer express a protein called Rap1A, which the authors hypothesized would interact with a2C - AR.

To overcome this challenge, the students altered a sub-unit of curli DNA, called ribosome binding sites (RBS), and then used these modified RBS to specifically tune protein production, explained Erin Kim, A.B.» 19, a molecular and cellular biology concentrator.

The new system, called Casilio, combines an altered version of CRISPR (CRISPR - dCas9) with the Pumilio RNA - binding protein system to enable much broader gene manipulation power.

In a process called oxidation, free radicals steal electrons from other molecules — fats, proteins, cell membranes, and even DNA — altering the fundamental structure of the affected molecule.