Sentences with phrase «alters gene activity»

The term has evolved to include any process that alters gene activity without changing the DNA sequence, and leads to modifications that can be transmitted to daughter cells.

The short answer is proteins and pieces of RNA that alter gene activity within cells.

Such tags alter gene activity without changing the information in genes.

A new study suggests that epigenetic effects — chemical modifications of the human genome that alter gene activity without changing the DNA sequence — may sometimes influence sexual orientation.

When produced in excess during times of adversity, these particular miRNAs trigger epigenetic changes, which alter gene activity to cope with these environmental hardships.

Mill and colleagues strongly suspect that the DNA methylation changes they observed alter gene activity.

Scientists think that changes in crotonylation can alter gene activity by turning genes on or off.

As well as generating mutations by inserting themselves into and disrupting genes, retrotransposons can alter gene activity if inserted into adjacent regulatory regions of DNA.

Through a series of tests, the team found that mutations were altering gene activity through two distinct mechanisms — both in the same «direction,» by disrupting the gene.

Cells respond to diverse stimuli by altering gene activity.

A 2013 study from the University of Surrey's Sleep Research Centre uncovered that as little as one sleep - deprived week of fewer than 6 hours of sleep each night, led to altered gene activity for over 700 genes.

Not exact matches

Many thoughtful citizens, including eminent scientists, oppose the deciphering and altering of the human gene structure, and are appalled by the proposed commercial uses of knowledge gained from such activities.

Researchers in England have found that in trace amounts, they activate estrogen receptors in cells, which in turn alters the activity of certain genes.

Because the prion - forming protein identified in the study normally functions as a regulator of gene activity, the researchers say their discovery raises the possibility that when it switches to a prion state, it could alter genetic expression and bacterial behavior.

Strapping other molecules to this «dead Cas9» allows scientists to alter genes or change the genes» activities.

Its altered form moves to the nucleus, where it increases the activity of a gene involved in metastasis (The Journal of Clinical Investigation, DOI: 10.1172 / JCI40433).

Most research on epigenetics has focused on the way everyday experiences alter patterns of gene activity in DNA during life through a chemical process of gene tagging called methylation, which usually silences genes.

Interestingly, this study shows that altered dopamine levels can modify gene activity through epigenetic mechanisms despite the absence of genetic mutations of the DNA.»

The researchers further found that miR - 486 is itself regulated by the tumor - suppressor gene p53, the most frequently altered gene in human cancers, and that activity of miR - 486 is partially dependent upon functional p53.

«Because many broadly expressed genes that play key roles in essential cellular functions are under the control of cell - specific enhancers, the ability to affect enhancer function by knocking down eRNAs could potentially provide a new strategy for altering gene expression in vivo in a cell - specific manner,» said Glass, noting that in his research, anti-sense oligonucleotides were developed in conjunction with Isis Pharmaceuticals, which suppressed enhancer activity and reduced expression in nearby genes.

Two of the mouse's genes had been altered so that the egg had a pattern of gene activity similar to that of a sperm.

Scientists have shown that this voltage change can trigger a cascade of biochemical reactions that relay messages to the cell nucleus, changing gene activity and altering cell growth and differentiation.

Now a dramatic new accomplishment has been added to nitric oxide's repertoire: altering the activity of genes.

They found that altering the activity of a gene called Cdk5 appeared to make the clocks run faster than normal, and the flies older than their chronological age.

More analysis showed that altering Cdk5 activity changed the level of several groups of genes that were also affected by aging, including those that control immunity, energy, and antioxidant activity.

By boosting pat - 10 activity, they were able to cure worms that had been altered to express the Huntington's disease gene, and also extend the lifespan of normal worms.

Most of those mutations are probably benign, but some may alter a protein's structure and function, or interfere with gene activity, leading to disease.

Informally called jumping genes, these bits of DNA can replicate and insert themselves into other regions of the genome, where they either lie silent, doing nothing; start churning out their own genetic products; or alter the activity of their neighboring genes.

Much of the previous research on epigenetics has focused on the fact that everyday experiences alter patterns of gene activity in DNA during life through a chemical process of gene tagging called methylation, which usually silences genes.

The researchers showed these relationships between ecRNA production and gene activity in neurons included genes whose expression is altered by neuronal activity and genes implicated in developmental and neurodegenerative disorders.

Now research with tiny, transparent zebrafish suggests that some of these bugs do more: altering the activity of individual genes in their host, and potentially shaping the fish's development and physiology.

They identified combinations of genes whose altered activities contributed to desirable traits; the functions of some of these genes were previously unknown, demonstrating the technique's ability to generate new biological knowledge.

Scientists have found that if a pregnant woman is exposed, the deadly contaminant can alter the activity of several genes in her fetus, potentially increasing the child's risk of cancer later in life.

The research team behind the study, which is being published in the journal Epigenetics, also found strong links between these altered epigenetic patterns and the activity in genes controlling improved metabolism and inflammation.

The research team led by Han used high - throughput techniques to alter the activity of dozens of genes in flies» hearts simultaneously in order to validate genes that cause heart disease.

Once the bacterial cell signaling protein cagA reaches the host cytosol, it is capable of altering subsequent generations of progenitor cells, leading to the development of cancer through changes in mitotic activity, apoptosis, cellular assembly, and signaling.26 Although it should be noted that while the presence of the cagA protein doubles the risk of gastric cancer, cagA - negative strands also increase the risk of distal gastric cancer.27 Additional H pylori virulence factors include babA2, which encodes bacterial adhesion with gastric epithelial cells, and vacuolating cytotoxin A, which is encoded by the gene vacA.28, 29 H pylori strains carrying some combination of the babA2, cagA, and vacA genes were associated with the highest risk of developing intestinal metaplasia.

Companion studies also shed light on the question of why boys are more likely to develop autism than girls, and begin to outline a network of genes whose activity is altered in the brains of individuals with autism.

Multidrug resistance gene G1199A polymorphism alters efflux transport activity of P - glycoprotein.

Tet2 is a type of cellular enzyme known as an epigenetic regulator — responsible for making specific chemical annotations to regions of DNA that alter the activity of many different genes.

The new data — from animals and human cells — show that the vapors released by e-cigarettes can alter the activity of genes.

PULLMAN — Researchers at Washington State University have identified a new class of DNA sequence variation in gene promoter regions that could help control the activity of genes.The novel variations, dubbed «multiple nucleotide length polymorphisms,» or MNLPs, altered transcription of the genes they were associated with as much as 11-fold.

Among females, however, vapors laced with nicotine altered the activity levels of 148 genes in the brain's frontal cortex.

This text covers topics ranging from plant genome structure and the key control points in how genes are expressed, to the mechanisms by which proteins are generated and how their activities are controlled and altered by posttranslational modifications.

In a pioneering study, he applied these tools to a genome - wide study of disease - related changes in the epigenome — the layer atop the genome that controls gene activity and is altered by the environment — of immune cells isolated from patients with asthma.

Preliminary findings suggest that the presence of certain symbiotic microbes alters the activity of genes that regulate the immune system.

Typically, these green fluorescent proteins are used to monitor the activity of altered genes.

In the different cell types of the body, different protein producing genes are active or inactive, and many medical conditions also depend on altered activity of specific genes.

In a time span of only a week of poor sleeping, the activity of hundreds of genes was altered.

In the book Relaxation Revolution: The Science and Genetics of Mind Body Healing, author Herbert (Benson) discusses how breathing can literally change the expression of genes, and that by using your breath, you can alter the basic activity of your cells with your brain.

The variant appears to alter the activity of MTDH / AEG -1 in cells, which regulates the activity of the EAAT2 gene: the EAAT2 protein is responsible for clearing glutamate from brain synapses in the brain....