Sentences with phrase «alters protein function»

Radical amino acid changes alter protein function.

Thus, such mutations might alter the protein function on chromatin state regulation, sensitizing PTCL - NOS patients to HDAC inhibitors.

We estimate that 42 % of our cohort carry pathogenic DNMs in coding sequences; approximately half of these DNMs disrupt gene function and the remainder result in altered protein function.

Not exact matches

Anything that changes the structure of that protein, then, can alter its function.

Because the prion - forming protein identified in the study normally functions as a regulator of gene activity, the researchers say their discovery raises the possibility that when it switches to a prion state, it could alter genetic expression and bacterial behavior.

Although the function of the gene isn't fully established, it is thought to add sugars to proteins, which could alter the speed or specificity of their usual function.

Huntington's disease is caused by an expansion of glutamine residues in the huntingtin protein, altering its function and ultimately resulting in toxic aggregation of huntingtin fragments in neurons.

Cells purposely produce the chemical, which can quickly oxidize proteins to alter their functions.

Changes to the properties of the lipid bilayer component of the cell membrane can alter the function of proteins embedded in the membrane — proteins that regulate critical functions such as transport of materials in and out of the cell and communication with other cells.

mTOR controls expression of proteins that alter mitochondrial structure and function in ways that unexpectedly protect cells from death, the team reported.

That is, when compounds intended to influence a specific protein target also alter lipid bilayer properties, they may alter the function of numerous membrane proteins and thereby cause a cascade of usually unwanted off - target and side effects.

The researchers studied mutations that alter the function of hemoglobin, the protein in charge of transporting oxygen in the blood.

«Shifting protein networks in breast cancer may alter gene function: Changes in gene function in tumor samples correlate with patient survival.»

«We have shown that the synthesis of nitric oxide (NO), known to regulate gut motility functions and NRF2, a transcriptional factor known to regulate several antioxidant genes, mediated Phase II protein expression have been altered in colon specimens of polybacterialinfected ApoE - / - mice,» said Miriam Walker.

For example, researchers can alter specific protein function and then determine whether this protein can be linked to sensitivity or resistance to anesthetic action in lower organisms.

RPM - 1 uses PPM - 2, an enzyme that removes a phosphate group from a protein thereby altering its function, in combination with ubiquitin ligase activity to directly inhibit DLK - 1.

While many protein factors are known to subtly regulate the function of T cells, David Munn and Andrew Mellor of the Medical College of Georgia in Augusta suggest that the fetus uses a cruder method to alter T cells» behaviour: starvation.

Most of those mutations are probably benign, but some may alter a protein's structure and function, or interfere with gene activity, leading to disease.

Rare variations, by contrast, are more likely to alter protein expression or function and therefore have a direct or causal association with a disease.

So far, scientists have found that different populations of living humans have inherited the Neandertal version of genes that cause diabetes, lupus, and Crohn's disease; alter immune function; and affect the function of the protein keratin in skin, nails, and hair.

Synonymous single - nucleotide polymorphisms (SNPs) do not produce altered coding sequences, and therefore they are not expected to change the function of the protein in which they occur.

But the protein's structure and function are altered.

For now, Stadler's team wants to focus on the regions in which it found altered gene numbers to see how the CNVs affect gene and protein functions.

Altering the function of the clock circadian regulator (CLOCK) and brain and muscle ARNT - like protein 1 (BMAL1), which keep cellular functions synchronized with day - night rhythms, could treat metabolic problems.

Enzymes in this family couple other proteins in the cell to a molecule called ubiquitin, a step that can alter the function or stability of these target proteins.

I am currently exploring functions of BIN1 by generating mouse models to modify the levels of BIN1 expression in the brain, and investigating how altering the levels of this protein can modify AD - related pathophysiology.

However, this cellular intervention alters the normal expression of hypophosphorylated retinoblastoma (RB) protein needed for the expression of genes involved in cell functions [3] and, therefore, results in an abnormal cell.

Our response to a study published in the Journal of Immunology looking at how carbon nanoparticles (such as those found in air pollution) can alter structure and function of certain proteins of the immune system.

Determining whether a disease - related protein can react strongly with a small - molecule probe or candidate drug — in a way that alters its function — is often an essential first step in drug development.

Only introducing the altered gene into cells and studying protein function in the lab provides that information, Traynelis says.

Enterohemorrhagic E. coli alters murine intestinal epithelial tight junction protein expression and barrier function in a Shiga toxin independent manner.

The most common approach is to focus on protein - truncating variants or PTVs (sometimes also called loss - of - function variants *) that terminate or substantially alter the protein sequence.

In the search for compounds that might alter a protein's behavior or function — such as that of alpha - synuclein — drug companies often rely on so - called target - based screens that test the effect large numbers of compounds have on the protein in question in rapid, automated fashion.

They then identified damaging mutations in the children that would disable the protein produced by a particular gene or alter the protein's function.

By enhancing the function of a single protein, Howard Hughes Medical Institute researchers have produced a «marathon mouse» with altered muscle composition and enough physical endurance to run twice...

For example, it modulates enzymatic activity, induces structural changes in proteins and nucleic acids, alters kinetics of molecular bonds, regulates motion of molecular motors, and has a role in mechanical transduction and sensory functions.

Rather than modify protein structure and function, these noncoding variants frequently impact regulatory elements and thereby alter the quantitative and spatiotemporal regulation of gene expression.

Previous observations suggest that these altered proteins would highly likely restore HRR function and be resistant to talazoparib (12).

A single poor transcript could therefore have devastating consequences, not just by directly altering a cell's enzymatic activity but through a domino effect that leaves other, unrelated proteins unable to function right.

The apoE4 protein differs from the apoE3 protein at only one point, but that single change is enough to alter its main structure and, thus, its function.

Small molecule a low molecular weight (usually less than 500 Daltons) organic compound that can bind to and alter the activity or function of proteins, nucleic acids, or polysaccharides.

The principle of proteolysis in vivo is to instigate irreversible changes to a set of protein substrates that alters their function and generates the required biological event.

This dichotomy points out the importance of an indirect influence on proteins whose altered function is required during carcinogenesis but are too essential to be mutated (i.e., mutation of their encoding genes could decrease the viability of cancer cells).

• Effects of soy isoflavones on the make - up of the gut microflora • Bacterial transformation of genetically modified soy DNA into gut bacteria capable of expressing toxic proteins that damage the intestinal lining • Effects of chemical contamination from glyphosate residues on neurological and gut function • Soy - induced activation of the immune system and altered production of inflammatory cytokines associated with febrile seizures

''... we hypothesize that repeated stress - related allostatic overload may affect brain function at three basic levels: (a) at the cellular level, it may compromise proteostasis (e.g. tau protein), organelles homeostasis, and induce epigenetic changes in neuronal DNA; (b) at the tissue level it may affect intracellular communication (synaptic contacts), number of cells (reduction of neuronal density), composition of the extracellular matrix (accumulation of amyloid plaques), and neuroinflammation; (c) at the systemic levels it may alter the brain's regulation of behavior (cognitive decline).

Glycated proteins and cellular structures have altered function, increased vulnerability to oxidative damage, and reduced degradation and clearance.6 Slowing the entry of glucose into the brain would delay these processes and possibly give the body's defenses more time to dispose of the AGEs.

Primary sarcopenia is a consequence of the aging process (e.g., reduced neurological function, altered muscle fiber type distribution, and increased protein turnover).

They even create residues on skin proteins and alter their functioning.

A common result of hepatic atrophy is hepatic insufficiency, which combined with the circulating toxins, proteins and nutrients, frequently results in hepatic encephalopathy, a clinical syndrome of altered central nervous system function due to failure of normal liver function.