Sentences with phrase «alters the cell tissues»

After all, the poison is absorbed into the subcutaneous layer, inevitably gets into the blood, spreads throughout the body and alters the cell tissues of the internal organs.

Not exact matches

Scientists are forced either to experiment on whole animals, which is expensive, raises ethical issues and may not predict effects in humans, or to perform tests on microscopic human cells found in tissue cultures, which have been altered to live forever and bear little relation to actual living, breathing people.

Tissue - engineered livers grown from stem cells, say, could have their genetic code altered so that they would be immune to liver - destroying viruses such as hepatitis C.

He reports that Advanced Cell Technology plans to clone genetically altered animals whose neural tissue would be immunologically compatible with that of humans.

As it can take weeks to grow human cells into intact differentiated and functional tissues within Organ Chips, such as those that mimic the lung and intestine, and researchers seek to understand how drugs, toxins or other perturbations alter tissue structure and function, the team at the Wyss Institute for Biologically Inspired Engineering led by Donald Ingber has been searching for ways to non-invasively monitor the health and maturity of cells cultured within these microfluidic devices over extended times.

Because neural crest cells contribute to so many tissues in the body, altering their function could change an animal's behavior, appearance and biology, the researchers reasoned.

The natural structures that exist either between cells or within cells are damaged during the freeze - thaw process and hence the flavor or texture of the tissue is altered.

The research suggests that reducing production of the protein, called myoferlin, affects cancer cells in two primary ways: by changing the activation of many genes involved in metastasis in favor of normal cell behavior, and by altering mechanical properties of cancer cells — including their shape and ability to invade — so they are more likely to remain nested together rather than breaking away to travel to other tissues.

Prior research with cultured tissue had shown that a mix of chemicals could change bone marrow stem cells from mice to those resembling brain cells, but when a team led by neurologist Lorraine Iacovitti of Thomas Jefferson University in Philadelphia tried the same brew on human cells, the number altered was modest.

In one study, geneticist Joseph Ecker at the Salk Institute in California took various stem cell lines reprogrammed from skin, fat, and other tissues and examined each line's genome for dna methylation, chemical marks that alter how genes are expressed.

The expression of another HOX gene, which helps specify what tissue sprouts a forelimb, was altered in the outer layer of cells in the python embryo.

Neuronal cells express a pp60c - src variant that displays an altered electrophoretic mobility and a different V8 peptide pattern relative to pp60c - src expressed in tissues of non-neuronal origin.

Previous reports suggest that obesity alters the mononuclear phagocytic cell content in the circulation and within adipose tissue.

Zhang's laboratory now seeks to understand the mechanisms of the tissue - environment influence, opening the possibility that the environment could be altered in a way that fights cancer by preventing tumor cell growth.

As new advances alter the possibilities of human reproduction, we must develop a morally sound body of law governing stem cell research and tissue donation.

Masters et al. discuss the often overlooked contribution of the stromal microenvironment as an extrinsic factor to immunosenescence and inflammation.12 Accumulation of senescent stromal cells which demonstrate the senescent associated secretory phenotype (SAPS), may alter tissue structure and function, and increase local inflammation.13 The impact of altered lymphoid stromal microenvironment may be widespread and include altered haematopoiesis, reduced lymphatic flow and disrupted secondary lymphoid organisation, which consequently will alter antigen transportation and presentation to T cells.12

«This could be important in regulating how these cells actually alter the structure of the host tissue,» explains Mooney.

Affected cells signal to surrounding unaffected cells and likely alter the tissue environment.

Dr. Yamanaka's iPS discovery, first completed with animal cells in 2006 and with human cells in 2007, has since altered the fields of cell biology and stem cell research — opening promising new prospects for drug discovery, personalized medicine and tissue regeneration.

The result is an accumulation of senescent cells, which causes inflammation, tissue degradation and the production of growth factors that alter the tissue microenvironment, leading to disease.

We don't know how these cells alter the electrical and mechanical properties of heart tissue, or the degree to which these changes are to blame for the ultimate shutdown of the heart.

Cellular senescence is the irreversible growth arrest of individual mitotic cells, which as a consequence display a radically altered phenotype that is thought to impair tissue function and predispose tissues to disease development and / or progression as they gradually accumulate.

In 2000, our founder Professor Yoram Palti sought to leverage his expertise in biophysics to develop a new way to treat cancer that would destroy tumor cells while sparing healthy tissue and avoiding many of the life - altering side effects of existing cancer therapies.

By utilizing the tools of cell and molecular biology, he studies the mechanisms by which chemical (for example, specific cell adhesion molecules) or mechanical signals (for example, cyclic strain) are sensed by cells and alter their proliferation and specialization to either promote tissue growth or destruction.

It also tenaciously binds with tissue altering DNA, nerves, cell membranes, mitochondrial function.

''... we hypothesize that repeated stress - related allostatic overload may affect brain function at three basic levels: (a) at the cellular level, it may compromise proteostasis (e.g. tau protein), organelles homeostasis, and induce epigenetic changes in neuronal DNA; (b) at the tissue level it may affect intracellular communication (synaptic contacts), number of cells (reduction of neuronal density), composition of the extracellular matrix (accumulation of amyloid plaques), and neuroinflammation; (c) at the systemic levels it may alter the brain's regulation of behavior (cognitive decline).

The altered microbiota was associated with changes in colonic short - chain fatty acid (SCFA) concentrations, colonic - tissue gene expression (Gsta2 and Ela1), and host physiology (serum metabolite profiles and colonic goblet cell numbers).

When an IgE antibody (even IgG can be involved) with an attached allergen encounters a mast cell under the skin, it alters the membrane of the cell, and histamine leaks into the surrounding tissue.