Sentences with phrase «although early clinical»

For example, although early clinical trials of Listeria - based vaccines have shown that the neutralized bacterium produces only mild flulike symptoms in human patients with cervical cancer, the various methods of genetically disarming the bacteria should be explored to find the safest approach for people gravely ill with pancreatic cancer, because these patients are likely to already have weak immune systems.

Not exact matches

This is an incredibly difficult question to answer for a variety of reasons, most importantly because over the years our once vaunted «beautiful» style of play has become a shadow of it's former self, only to be replaced by a less than stellar «plug and play» mentality where players play out of position and adjustments / substitutions are rarely forthcoming before the 75th minute... if you look at our current players, very few would make sense in the traditional Wengerian system... at present, we don't have the personnel to move the ball quickly from deep - lying position, efficient one touch midfielders that can make the necessary through balls or the disciplined and pacey forwards to stretch defences into wide positions, without the aid of the backs coming up into the final 3rd, so that we can attack the defensive lanes in the same clinical fashion we did years ago... on this current squad, we have only 1 central defender on staf, Mustafi, who seems to have any prowess in the offensive zone or who can even pass two zones through so that we can advance play quickly out of our own end (I have seen some inklings that suggest Holding might have some offensive qualities but too early to tell)... unfortunately Mustafi has a tendency to get himself in trouble when he gets overly aggressive on the ball... from our backs out wide, we've seen pace from the likes of Bellerin and Gibbs and the spirited albeit offensively stunted play of Monreal, but none of these players possess the skill - set required in the offensive zone for the new Wenger scheme which requires deft touches, timely runs to the baseline and consistent crossing, especially when Giroud was playing and his ratio of scored goals per clear chances was relatively low (better last year though)... obviously I like Bellerin's future prospects, as you can't teach pace, but I do worry that he regressed last season, which was obvious to Wenger because there was no way he would have used Ox as the right side wing - back so often knowing that Barcelona could come calling in the off - season, if he thought otherwise... as for our midfielders, not a single one, minus the more confident Xhaka I watched played for the Swiss national team a couple years ago, who truly makes sense under the traditional Wenger model... Ramsey holds onto the ball too long, gives the ball away cheaply far too often and abandons his defensive responsibilities on a regular basis (doesn't score enough recently to justify): that being said, I've always thought he does possess a little something special, unfortunately he thinks so too... Xhaka is a little too slow to ever boss the midfield and he tends to telegraph his one true strength, his long ball play: although I must admit he did get a bit better during some points in the latter part of last season... it always made me wonder why whenever he played with Coq Wenger always seemed to play Francis in a more advanced role on the pitch... as for Coq, he is way too reckless at the wrong times and has exhibited little offensive prowess yet finds himself in and around the box far too often... let's face it Wenger was ready to throw him in the trash heap when injuries forced him to use Francis and then he had the nerve to act like this was all part of a bigger Wenger constructed plan... he like Ramsey, Xhaka and Elneny don't offer the skills necessary to satisfy the quick transitory nature of our old offensive scheme or the stout defensive mindset needed to protect the defensive zone so that our offensive players can remain aggressive in the final third... on the front end, we have Ozil, a player of immense skill but stunted by his physical demeanor that tends to offend, the fact that he's been played out of position far too many times since arriving and that the players in front of him, minus Sanchez, make little to no sense considering what he has to offer (especially Giroud); just think about the quick counter-attack offence in Real or the space and protection he receives in the German National team's midfield, where teams couldn't afford to focus too heavily on one individual... this player was a passing «specialist» long before he arrived in North London, so only an arrogant or ignorant individual would try to reinvent the wheel and / or not surround such a talent with the necessary components... in regards to Ox, Walcott and Welbeck, although they all possess serious talents I see them in large part as headless chickens who are on the injury table too much, lack the necessary first - touch and / or lack the finishing flair to warrant their inclusion in a regular starting eleven; I would say that, of the 3, Ox showed the most upside once we went to a back 3, but even he became a bit too consumed by his pending contract talks before the season ended and that concerned me a bit... if I had to choose one of those 3 players to stay on it would be Ox due to his potential as a plausible alternative to Bellerin in that wing - back position should we continue to use that formation... in Sanchez, we get one of the most committed skill players we've seen on this squad for some years but that could all change soon, if it hasn't already of course... strangely enough, even he doesn't make sense given the constructs of the original Wenger offensive model because he holds onto the ball too long and he will give the ball up a little too often in the offensive zone... a fact that is largely forgotten due to his infectious energy and the fact that the numbers he has achieved seem to justify the means... finally, and in many ways most crucially, Giroud, there is nothing about this team or the offensive system that Wenger has traditionally employed that would even suggest such a player would make sense as a starter... too slow, too inefficient and way too easily dispossessed... once again, I think he has some special skills and, at times, has showed some world - class qualities but he's lack of mobility is an albatross around the necks of our offence... so when you ask who would be our best starting 11, I don't have a clue because of the 5 or 6 players that truly deserve a place in this side, 1 just arrived, 3 aren't under contract beyond 2018 and the other was just sold to Juve... man, this is theraputic because following this team is like an addiction to heroin without the benefits

Although some SIDS experts and policy - makers endorse pacifier use recommendations that are similar to those of the AAP, 272,273 concerns about possible deleterious effects of pacifier use have prevented others from making a recommendation for pacifier use as a risk reduction strategy.274 Although several observational studies275, — , 277 have found a correlation between pacifiers and reduced breastfeeding duration, the results of well - designed randomized clinical trials indicated that pacifiers do not seem to cause shortened breastfeeding duration for term and preterm infants.278, 279 The authors of 1 study reported a small deleterious effect of early pacifier introduction (2 — 5 days after birth) on exclusive breastfeeding at 1 month of age and on overall breastfeeding duration (defined as any breastfeeding), but early pacifier use did not adversely affect exclusive breastfeeding duration.

Several compounds that boost glutamate signalling in the brain have reached early clinical trials, although it is too soon to say if they will pass the larger trials needed to prove their worth.

Although this study is limited by the lack of data on the effects of clinical interventions and neonatal resuscitation efforts that may have been performed at the time of birth, these findings suggest that early detection of perinatal asphyxia is particularly relevant among infants of overweight and obese women although more studies are necessary to confirm these results in other popuAlthough this study is limited by the lack of data on the effects of clinical interventions and neonatal resuscitation efforts that may have been performed at the time of birth, these findings suggest that early detection of perinatal asphyxia is particularly relevant among infants of overweight and obese women although more studies are necessary to confirm these results in other popualthough more studies are necessary to confirm these results in other populations.

Although it's still early days for this new form of treatment, the FDA has already been approached by new start - up company Cognito Therapeutics about going ahead with clinical trials for testing.

Although earlier reports emphasize that the percentage of NIH extramural grant dollars devoted to clinical research depends on the inclusiveness of the definition of clinical research, 5,14,18,29 the primary purpose of the current analysis was to describe outcomes of the scientific review of grant applications rather than to provide a comprehensive overview of extramural NIH funding for clinical research.

Although these lysosomal therapies are being tested in early - stage clinical trials, they inhibit other lysosomal functions beyond autophagy, and therefore may have additional side effects.

In earlier placebo - control clinical studies, most of the adverse events seen in dogs treated with Anipryl ® were also seen in placebo - treated dogs, although rates in placebo - treated dogs were lower.

SEVERAL FINDINGS suggest that juvenile - and adult - onset major depressive disorder (MDD) have distinct origins.1 First, although a significant proportion of depressed children become depressed adults, 2,3 most individuals who experience depression in adulthood were not depressed as children.4 Second, juvenile - onset MDD is associated with increased risk for MDD among the first - degree relatives of depressed probands in clinical and community samples.4 - 8 Third, the children of depressed parents are at high risk for juvenile - onset MDD compared with the children of nondepressed parents, and this association is explained by early parental age at onset of MDD.9

Childhood sexual abuse and childhood physical abuse are among the strongest predictors of psychiatric pathology and severity of clinical course, including suicide.2,4 - 14 The influence of childhood sexual abuse and childhood physical abuse on psychological development is thought to be mediated directly by changes in cognitive processing of threatening stimuli,15 - 18 resulting in enhanced negative affect to daily life stressors.19 Although there is a clear link between early - life adversity and psychopathology, very little is known about the molecular mechanisms responsible for the long - lasting behavioral consequences of childhood abuse.

In New Zealand, recent strengthening of the Māori health workforce has led to a number of successes: interventions led by, focused on, and targeted to Māori; consistent investment in Māori health over a prolonged period; and an emphasis on the development of dual cultural and clinical competencies.14 In the United States, successful Native American health service development in the early 1990s appears to have been shaped by federal government administration, the separation of the Indian Health Service from other Native American affairs, and provision of an integrated health service.15 In both countries, recent reductions in overall death rates for indigenous people have been noted; in the US this relates to injury prevention, whereas in NZ it relates to fewer deaths due to circulatory conditions.16 Although it is not known whether improved health services for indigenous peoples in the US and NZ have a causal relationship with decreased mortality, the two appear to «travel together» well.

Currently, there is limited evidence about the effectiveness of clinical interventions for young people who engage in self - harm, although there has been much work in the area since the earliest systematic review [18].