Lu is a medical student interested in the role of epigenetic regulation in high
altitude adaptation and hypoxia response.
Altitude adaptation in Tibetans caused by introgression of Denisovan - like DNA.
Genetic signatures reveal high -
altitude adaptation in a set of Ethiopian populations Huerta - Sánchez, E., M. DeGiorgio, L. Pagani, A. Taretegn et al. 2013.
Genetic signatures reveal high -
altitude adaptation in a set of Ethiopian populations.
We report genome - wide scans that reveal positive selection in several regions that contain genes whose products are likely involved in high -
altitude adaptation.
Identification of these genes provides support for previously hypothesized mechanisms of high -
altitude adaptation and illuminates the complexity of hypoxia - response pathways in humans.
Studies have linked
their altitude adaptation to several genes including EPAS1, part of the system that helps the body react to low levels of oxygen.
-- The Nielsen Group is still working on high
altitude adaptations.
Not exact matches
One group of high -
altitude birds in the Canadian Rockies sang songs that stood out other members of their subspecies, which Roach and Phillmore believe is an
adaptation to how sound carries in their open, shrubby habitat.
When population geneticist Andrea Manica and graduate student Marcos Gallego Llorente at the University of Cambridge in the United Kingdom analyzed the sequence, they found that the Mota man had brown eyes and dark skin, as well as three gene variants associated with
adaptation to high
altitudes; some peaks in the highlands reach 4500 meters, as high as the Matterhorn.
«Our new approach is poised to reveal the evolutionary
adaptations for countless other environments, from the sea, high
altitudes, the desert, or even underground.»
Findings of the study gave been published in a paper entitled «Ground tit genome reveals avian
adaptation to living at high
altitudes in the Tibetan plateau» in the journal Nature Communications.
More research will need to be done comparing genomes from closely related species inhabiting high
altitudes and lowland environments to further explore the genetic foundation of these
adaptations.
«One major
adaptation is a positive selection for genes involved in hypoxia response and skeletal development, similar to those expressed in other organisms in high -
altitude environments such as Tibet and the Andes,» Dr Subramanian said.
Similarly, certain mtDNA variants are enriched in Tibetan populations, suggesting that mtDNA variation may permit
adaptation to the low oxygen tension at high
altitude.
EPO concentrations and red blood cell volumes had risen in each of the four groups, suggesting that contrary to long - held wisdom, these
adaptations aren't the only reason
altitude training enhances performance.
Living at an
altitude of up to 4000 metres above sea level, the Atlas Day gecko has a suite of
adaptations to help it cope with the cold
Pikas, which include about 30 species all living at different
altitudes, have likely evolved special
adaptations for living where they do.
One newly discovered genetic
adaptation helps Tibetans produce more folate, which aids in pregnancy but can become depleted at high
altitudes.
Some high -
altitude people, such as Andean highlanders, have an
adaptation that adds more oxygen - rich hemoglobin to their blood.
Though once widespread, this endangered species is only limited to fragmental mountain forests, and the highest
altitude (up to 4,500 meters) of any primate, making them a fascinating subject for evolutionary biologists to study to reveal the genetics behind their
adaptations.
Even more revealing, both prehistoric individuals and contemporary Tibetan populations shared beneficial mutations in two genes, EGLN1 and EPAS1, which are implicated in
adaptation to low - oxygen conditions found at high
altitudes, but EGLN1
adaptations were observed earlier.
Sequencing of 50 human exomes reveals
adaptation to high
altitude Yi, X., Y. Liang, E. Huerta - Sanchez, X. Jin et al..
Some mitochondrial SNPs have been associated with various characteristics, such as
adaptation to cold weather or high
altitude environments and have been implicated in susceptibility to diabetes and various inflammatory diseases.
A new study published in PLoS Genetics ascribes the
adaptations in honeybees that reside at high
altitudes to ancient genetic alterations.
Read the original research article here — «Genetically based low oxygen affinities of felid hemoglobins: lack of biochemical
adaptation to high -
altitude hypoxia in the snow leopard.».
(The reason for a range is because of a number of variables like your own
adaptation to heat, humidity,
altitude etc..
Intelligent
adaptation to terrains and
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