Stage I lactogenesis, or secretory initiation, occurs during pregnancy and is defined by the differentiation of mammary
alveolar epithelial cells into specialized secretory cells, termed lactocytes (1).
Calcitonin Gene - Related Peptide Enhances the Expression of Signaling Molecules of the Wnt 7b / Beta - Catenin Pathway in Rat Type II
Alveolar Epithelial Cells Under Hyperoxia Hyperoxic lung injury is characterized by epithelial cell death and leukocyte infiltration / inflammation in the lung.
In the first half of pregnancy secretory differentiation (the differentiation
of alveolar epithelial cells into milk - secreting cells), ductal branching and lobular formation of the breast (mammogenesis) occur.
Organ - on - a-chip technology may in part overcome this limitation, as exemplified by the «breathing» lung - on - a-chip that recapitulates the alveolar - capillary interface by co-culturing
human alveolar epithelial cells and capillary endothelial cells on opposite sides of a flexible, porous, ECM - coated membrane.
Calcitonin Gene - Related Peptide Enhances the Expression of Signaling Molecules of the Wnt 7b / Beta - Catenin Pathway in Rat Type II
Alveolar Epithelial Cells Under Hyperoxia
The researchers determined that
the alveolar epithelial cells are typically protected from influenza infection by immune cells called alveolar macrophages.
«When we look at pandemic strains of influenza that have high mortality rates, one of the best adaptations of those pandemic viruses is their ability to infect
these alveolar epithelial cells,» explained researcher Amber Cardani, PhD.
This study therefore was designed to examine the regulatory role of CGRP in the Wnt7b / β - catenin pathway in type II
alveolar epithelial cell (AEC II) under hyperoxia.
Calcitonin gene - related peptide; Type II
alveolar epithelial cell; Oxidative stress; Lung injury; Wnt7b; β - catenin