Sentences with phrase «amount of change required»

«There are positive signs of departments beginning to engage with the issue, but there is still a vast amount of change required.»

Not exact matches

The changing attitude toward punctuality and reliability was the only other issue requiring a disproportionate amount of attention, according to the respondents.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

If the SEC requires companies to file excessive amounts of paperwork, many entrepreneurs may choose to not take advantage of the rule change, says Eakin.

«Although we had identified the various risks associated with integration, including the amount and pace of change required, we underestimated the impact and the time needed for the organization to adapt to those changes.

The Board or the HRC or the GNC may modify, suspend, or terminate the LTICP but may not, without the prior approval of our stockholders, make any change to the LTICP that increases the total amount of common stock which may be awarded (except to reflect changes in capitalization), increases the individual maximum award limits (except to reflect changes in capitalization), changes the class of team members or directors eligible to participate, extends the duration of the LTICP, reduces the exercise price of or reprices outstanding stock options or stock appreciation rights, waives the LTICP's minimum time period requirements for vesting and lapse of restrictions for restricted stock or RSRs, or otherwise amends the LTICP in any manner requiring stockholder approval by law or under the NYSE listing requirements.

However, in most cases the amortization period changes because different borrowing terms, interest rates and payments against the principal amount at each renewal vary the length of time required to pay off the mortgage.

Monetary policy is maintained through actions such as modifying the interest rate, buying or selling government bonds, and changing the amount of money banks are required to keep in the vault (bank reserves).

Change your name, picture, post or reply requires a very small amount of Bitcoin Cash (less than one cent) to complete.

I do not yet know what all of Levin's proposed Liberty Amendments are — apparently, there is a new crack at Congressional term limits, which I am iffy about, an amendment for Supreme Court decisions to be expunged by 60 % of Congress or the States, which I am very iffy about, one providing Supreme Court term limits, which I am cool with, one requiring bureaucracy - ordered rule - changes to be subject to Congressional approval when they affect the economy by a certain amount, which I am also.

You can argue that the original organism had better eyesight than others of his species and therefore the change increased his ability to survive, but you ignore that the change had to occur in the first place, and if there was a change in the first animal the interconnectedness of the related bodily functions makes it impossible for the chance change — which by the way required the loss of genetic material — to have happened regardless of the amount of time you had.

A combination of climate change (which has significantly shortened the cycles of drought), massive migration to the cities and market pressures to grow cash crops that require huge amounts of water have depleted India's already taxed water supply for rural areas.

Also, their concept that time dilattion accounts for the day - epoc disparity is flawed because neither God nor man would be in a frame of reference where there is enough changing amount of gravition / acceleration required for the changing time - dilation effect.

This requires a large amount of effort on the part of the farm, documenting all energy usage, greenhouse gas emissions and more, and documenting that Aquiares do not contribute to climate change.

I expect a fair amount of change to happen between now and then, and no one has a NMC that will require being protected, so I'm not sure how you've concluded that we will have an ugly protection list.

I said it last summer and ive been proven sadly right that OG and Theo are just NOT good enough to score the amount of goals required to win the EP, that situation has NOT changed and is unlikely to change this summer as well, so as I read reports that OG is to lead the line again next season and I feel its unlikely that Wenger will spend any real big money on a proven goal scoring monster then the same thing will happen again next season.

Heather McNamara: They are going to require you to change every two to three hours and then you always want to change the second your baby poops in a diaper, so you never want to let that go for any amount of time because that's really going to cause rashes.

For newborns who had any spitting up in the first 24 hours after birth, the following information was added: time of the event, the newborn's position during the event, wake or sleep state, estimated amount of regurgitation, color changes (duskiness, redness, or cyanosis) and intervention (if any) required (ie, stimulation, «blow - by» oxygen, suction)(Table 1).

De Blasio's Mandatory Inclusionary Housing zoning change would require some new construction to include a certain amount of permanently affordable housing.

The agency said proposed changes in the Two Bridges Large Scale Residential Plan amounted to a «minor modification» as opposed to a «major modification» of the plan, meaning a ULURP was not required.

Next Steps Algae biofuels should benefit from recent changes to the Renewable Fuel Standard, a set of regulations that require gasoline in the United States be blended with a certain amount of renewable fuel.

Nevertheless, the demand side grows fastly with booming population growth and urbanization, while the supply side is more endangered with increasing water scarcity due to global change, limited phosphorus reserves and vast amounts of energy required for nitrogen production.

The report is silent on the total amount of funding required to study the changing Arctic, but it suggests a number of structural changes to funding mechanisms.

The level of VTA stimulation required to activate these structures was considerably less than the amount required to reinforce or change behavior in the earlier experiments.

«Crop yields have steadily improved over the past 60 years, but the amount of water required to produce one ton of grain remains unchanged — which led most to assume that this factor could not change.

These actuators require large amounts of air or water to change shape, making the machines slow, bulky and difficult to untether.

Because they are habitat specialists requiring a very specific amount of precipitation, they are likely to be unprepared to face ongoing temperature variability and changing precipitation levels.

Changing this «preference» requires a certain amount of energy.

It is important to keep in mind that the required amount of sleep per day changes with age, and studies indicate the following recommended sleep durations:

However, not enough fiber consumption will change the constitution of the stool and increase the amount of force required during defecation.

This change also requires manufactures to publish information in larger / bolder type and to disclose actual amounts of nutrients.

Each country requires its own AdWords campaign, so manually changing bids required an exorbitant amount of time.

Growing, processing, shipping, and preparing food — particularly the kind Americans typically eat (and schools typically serve)-- requires huge amounts of energy and produces tons of waste: Animal agriculture contributes nearly one - fifth of the greenhouse - gas emissions responsible for climate change — 1 pound of beef generates the equivalent of 36 pounds of carbon dioxide, according to researchers.

After publication, changes would require a significant amount of work as the material would need to be republished.

First, the county board of supervisors slashed funds for its public schools to $ 150,000, the minimum amount legally required in 1955 — $ 550,000 less than the nearly $ 700,000 requested by the county school board.9 Along with allocating fewer funds for the County's schools, supervisors also voted to switch how often they would distribute those funds, changing the schedule from an annual basis to a monthly basis.

Those minutes that are supposed to be devoted to planning are often filled with endless amounts of paperwork, meetings, interruptions, schedule changes, extra assigned duties, phone calls, conferences, gathering missed work for absent students, completing forms, submitting required data and on and on.

Students will still receive the state - mandated amount of instructional time, though the change will require approval by the Orleans Parish School Board, Dupre said.

The student will be required to create and write a poster, read, measure and follow a recipe to make lemonade, count money, and add and subtract to issue the correct amount of change.

I say «might be» because, in modelling this situation, one can not get away from the dependence on multiple factors, such as the 5 listed above So if (for example) the natural rates of deceleration after downshifting and in neutral are the same, that doesn't mean it would take the same force of stepping on the brakes in both cases to further change the deceleration by the required amount.

That's why we've issued new rules limiting how much time passengers can sit in planes stuck on the tarmac; requiring airlines to refund baggage fees if they don't deliver your luggage on time; mandating that airlines prominently disclose all potential fees — including luggage fees, meal fees, change fees, or cancellation fees; and doubling the amount of voucher money for which passengers are eligible if they're involuntarily bumped from an oversold flight.

This helps to reduce the amount of steering effort required, provides excellent agility in dynamic driving situations, ensures comfortable and assured responses when changing lanes and navigating through corners, and reduces the car's turning circle.

«Comfort» mode requires only a small amount of steering force when parking or maneuvering, but still provides the M brand's hallmark direction - changing precision at higher speeds.

BMW's Active Steering technology changes the amount of input required to turn the wheels depending on the car's speed.

In case of name change, the Customer will be required to make a fresh booking with the new name and pay the booking amount at the time of the booking again.

Variable rates are usually lower but the amount you pay each month or the number of payments you're required to make can change.

David Trahair: Which brings up the other thing Doug, if somebody did take the time to track their finances and saw the incredible amount of interest that they're wasting, maybe that will trigger them to change their habits, which is what really is required.

You're required to fill out this form when you start working for an employer, and you can fill out a new one whenever your circumstances call for a change in the amount of withholding.

Colonial Penn's term and whole life insurance products don't require a medical exam and have a maximum death benefit of $ 50,000, meaning you'll typically pay higher premiums and won't be able to purchase a greater amount of coverage should your financial needs change.

Monetary policy is maintained through actions such as modifying the interest rate, buying or selling government bonds, and changing the amount of money banks are required to keep in the vault (bank reserves).

Changes in the Death Benefit Option may result in changes to the policy's Face Amount and may require evidence of insuraChanges in the Death Benefit Option may result in changes to the policy's Face Amount and may require evidence of insurachanges to the policy's Face Amount and may require evidence of insurability.