Not exact matches
For Business Insurance and Bond & Specialty Insurance, retention is the
amount of premium available for renewal that was retained, excluding
rate and exposure
changes.
Expenses can be divided into fixed (those that must be paid, usually at the same
rate, regardless
of the volume
of business) and variable or semivariable (those which
change according to the
amount of business).
This would mean significant
change to the
amount of greenhouse gas in the atmosphere and would slow down the
rate of warming.
These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the
amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability
of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction
of generic versions
of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect
of lowering prices or reducing the number
of insured patients; the possibility
of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels
of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits
of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages
of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development
of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to
changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange
rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).
The market expected that Britain would have to devalue its currency and no
amount of interest
rate hikes or currency purchasing would
change that.
The market expected that Britain would have to devalue its currency and that no
amount of interest
rate hikes or currency purchasing would
change that.
Duration is a measure that helps estimate the
amount the price
of a bond will rise or fall in response to
changes in interest
rates.
Forward - looking statements may include, among others, statements concerning our projected adjusted income (loss) from operations outlook for 2018, on both a consolidated and segment basis; projected total revenue growth and global medical customer growth, each over year end 2017; projected growth beyond 2018; projected medical care and operating expense ratios and medical cost trends; our projected consolidated adjusted tax
rate; future financial or operating performance, including our ability to deliver personalized and innovative solutions for our customers and clients; future growth, business strategy, strategic or operational initiatives; economic, regulatory or competitive environments, particularly with respect to the pace and extent
of change in these areas; financing or capital deployment plans and
amounts available for future deployment; our prospects for growth in the coming years; the proposed merger (the «Merger») with Express Scripts Holding Company («Express Scripts») and other statements regarding Cigna's future beliefs, expectations, plans, intentions, financial condition or performance.
Rainfall, both the
amount and the
rate, represents one
of the strongest signals
of climate
change.
Your payment
amount can
change depending on HELOC interest
rate fluctuations, your credit line balance and the number
of days in each month.
Factors that could cause actual results to differ materially from those expressed or implied in any forward - looking statements include, but are not limited to:
changes in consumer discretionary spending; our eCommerce platform not producing the anticipated benefits within the expected time - frame or at all; the streamlining
of the Company's vendor base and execution
of the Company's new merchandising strategy not producing the anticipated benefits within the expected time - frame or at all; the
amount that we invest in strategic transactions and the timing and success
of those investments; the integration
of strategic acquisitions being more difficult, time - consuming, or costly than expected; inventory turn;
changes in the competitive market and competition amongst retailers;
changes in consumer demand or shopping patterns and our ability to identify new trends and have the right trending products in our stores and on our website;
changes in existing tax, labor and other laws and regulations, including those
changing tax
rates and imposing new taxes and surcharges; limitations on the availability
of attractive retail store sites; omni - channel growth; unauthorized disclosure
of sensitive or confidential customer information; risks relating to our private brand offerings and new retail concepts; disruptions with our eCommerce platform, including issues caused by high volumes
of users or transactions, or our information systems; factors affecting our vendors, including supply chain and currency risks; talent needs and the loss
of Edward W. Stack, our Chairman and Chief Executive Officer; developments with sports leagues, professional athletes or sports superstars; weather - related disruptions and seasonality
of our business; and risks associated with being a controlled company.
Due to the large and expanding scale
of our international business activities, any
changes in the U.S. or foreign taxation
of such activities may increase our worldwide effective tax
rate and the
amount of taxes we pay and seriously harm our business.
However, if the ordinary shares or ADSs are treated as traded on an «established securities market» and you are either a cash basis taxpayer or an accrual basis taxpayer that has made a special election (which must be applied consistently from year to year and can not be
changed without the consent
of the IRS), you will determine the U.S. dollar value
of the
amount realized in a non U.S. dollar currency by translating the
amount received at the spot
rate of exchange on the settlement date
of the sale.
That
change would have raised revenue to help Republicans offset the losses from the massive
rate cuts, and some proponents
of it argued that the state and local tax deduction (known as «SALT»)
amounted to a federal subsidy
of high - tax states.
When interest
rates change, a bond's price will
change in the opposite direction
of rates by a corresponding
amount.
The
amount of return you receive on an exchange traded note depends on and is based on the performance
of a specific market index; whereas, the value
of the exchange traded note is affected by
changes in credit
ratings...
However, in most cases the amortization period
changes because different borrowing terms, interest
rates and payments against the principal
amount at each renewal vary the length
of time required to pay off the mortgage.
Monetary policy is maintained through actions such as modifying the interest
rate, buying or selling government bonds, and
changing the
amount of money banks are required to keep in the vault (bank reserves).
The velocity
of money measures the
rate at which money flows through an economy, in other words, how much money
changes hands; it has to do with the
amount of economic activity associated with a given money supply.
Examples
of these risks, uncertainties and other factors include, but are not limited to the impact
of: adverse general economic and related factors, such as fluctuating or increasing levels
of unemployment, underemployment and the volatility
of fuel prices, declines in the securities and real estate markets, and perceptions
of these conditions that decrease the level
of disposable income
of consumers or consumer confidence; adverse events impacting the security
of travel, such as terrorist acts, armed conflict and threats thereof, acts
of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread
of epidemics and viral outbreaks; adverse incidents involving cruise ships;
changes in fuel prices and / or other cruise operating costs; any impairment
of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary
amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion
of our assets pledged as collateral under our existing debt agreements and the ability
of our creditors to accelerate the repayment
of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange
rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss
of key personnel; future
changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price
of, or major
changes or reduction in, commercial airline services; seasonal variations in passenger fare
rates and occupancy levels at different times
of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability
of attractive port destinations; pending or threatened litigation, investigations and enforcement actions;
changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.
I recommend a major
change to the tax system: Replace the intrusive loophole - ridden income tax with the combination
of a universal fixed -
rate sales tax and a universal fixed -
amount rebate.
Mortgage calculators are automated tools accessible over the internet and help determine the effect
of changes to any
of the mortgage loan components such as the interest
rate, repayment
amount, principal
amount, etc..
Dana has intimate familiarity with what it takes to make significant
changes in a large, urban district like my own, and she is less - than - starry - eyed about the ability
of any other district to follow suit without outside funding — over and above the current USDA reimbursement
rate, OR that
amount plus six cents.
Some Democratic lawmakers have raised the possibility
of making some
changes to the cap law, which limits increases in the
amount collected in taxes to 2 percent or the
rate of inflation.
They found that after 180 days neither dose led to measurable
changes in the soil's mix
of DNA and molecules found in bacterial cell walls (which reveals the
amount and types
of bacteria present), its levels
of nutrients or
rate of CO2 formation — the latter
of which reflects how well the bacteria are utilizing oxygen.
In fact,
changes due to mutations in the mitochondrial DNA over time can be used to distinguish groups and also to estimate the
amount of time that has passed since two individuals shared a common ancestor, as these mutations occur at predictable
rates.
Paleontologists have long suspected that these observations reflect a fundamental coupling between the
rates of species formation and anatomical
change: groups
of organisms that contain lots
of species also seem to have greater
amounts of anatomical variation, while groups with only a few species, such as the gar, lack much morphological variety.
Any massive, long - term
changes in their numbers could alter fish migration patterns, growth
rates, and mortality, as well as
change the
amount of oxygen and carbon dioxide in the atmosphere.
«The
amount and diversity
of pesticides, pharmaceuticals and other industrial chemicals that humans are releasing into the environment are increasing at
rates that match or exceed recent increases in CO2 emissions, nutrient pollution from nitrogen fertilizers, and other drivers
of global
change,» Bernhardt said.
This distribution remained the same when they
changed the
rate and
amount of shaking, the density
of the particles and the shape
of the container.
To quantify the overall effect
of contrast - dependent
changes to output nonlinearities, we constructed a measure
of how these adaptive shifts
change the
amount of information a unit's firing
rate carries about the ongoing stimulus (Figure 5F).
Rate of change question — would methane - using microorganisms be likely to have handled most methane as it was released from warming at geological rates of change, but not increase fast enough to metabolize the amounts of methane described at current rate of cha
Rate of change question — would methane - using microorganisms be likely to have handled most methane as it was released from warming at geological
rates of change, but not increase fast enough to metabolize the
amounts of methane described at current
rate of cha
rate of change?
Studies have shown that even when people have lost huge
amounts of weight, the actual
change in their basal metabolic
rate is around ~ 10 % -15 %.
In the short term, your body will undergo the following
changes: ventilation (respiratory
rate) increases in response to a lower
amount of oxygen in the blood, blood then becomes more alkaline (meaning less acidic) as you hyperventilate, and this alkaline state in turn signals your body to breathe less than you should in order to get substantial oxygen to your tissues.
In animal studies,
changes include decreased body temperature, less spontaneous activity, and lowered resting metabolic
rate (the
amount of energy the body uses while at rest.)
Also the fiber in the nuts
changes the
rate that the fats in the nuts is absorbed, so that would
change the
amount of fat in the blood, since the body is also working to remove the fat and put it into storage.
Even if the caffeine was capable
of raising your metabolic
rate by 100 calories in a day, this
amount wouldn't
change the
amount of body fat you have.
You're just static in that chair, and so watching these images on the screen are potentially
changing your heart
rate, your blood pressure, the
amount of stress hormone that's floating through your blood stream in that moment, and maybe those images that you see in the movie have such staying power that you have a nightmare that night or you can't sleep very well.
So, for an overwhelming
amount of people (really, everyone Dr. Maffetone has looked at) the MAF heart
rate does not
change with sport.
When your thyroid doesn't produce the correct
amount of hormone, you may experience
changes in heart
rate and other concerning symptoms.
The Chinese no longer eat this way today, opting instead for increasing
amounts of meat; their decreasing health and rising obesity
rate is a reflection
of this recent
change.
Until now we were recalculating the
amount in your currency on the date
of the actual member payment and on the date when the payment is made to you therefore the
amounts may have
changed quite noticeably when the
rate rose or dropped significantly.
Because
of changing military assignments, the maximum
amount of time most children spend in one school is three years; the annual mobility
rate is 35 percent.
Beginning in 2003, after our data were collected, the Chilean government sought to alter several features
of the system, although not all
of the
changes have been fully implemented: Rather than providing vouchers at a flat
rate, voucher
amounts are to be tied to family income.
Comparing
changes in search
rates to mobility
rates also provides a lower bound on the
amount of online searching done by existing residents because
of choice.
I say «might be» because, in modelling this situation, one can not get away from the dependence on multiple factors, such as the 5 listed above So if (for example) the natural
rates of deceleration after downshifting and in neutral are the same, that doesn't mean it would take the same force
of stepping on the brakes in both cases to further
change the deceleration by the required
amount.
The cooling
rate of the evaporator has not
changed, it is still pulling in a fixed
amount of heat.
«When the driver selects a new mode, the software will enable some new subsystems, disable others, and reference new columns and rows in calibration tables, which
change the
amount of torque,
rate at which torque is increased or decreased, and how the torque is biased left and right,» Kuczera said.
However, rather than
change the balance
of the car, the spring
rates increase by the same
amount front and rear to maintain some consistency in the way the Cayenne drives.
Being able to
change the spring
rate (the system reduced the
amount of air when it needs to increase the spring
rate — less air is harder to compress for a given suspension movement) in conjunction with tuning the damping
rate via Porsche's PASM (Porsche Active Suspension Management) system is key to the Panamera's ability to offer excellent ride and yet still deliver sharp, sports - car - like handling.