Sentences with phrase «amyloid beta builds»
«Though several studies have suggested that amyloid beta builds up when we lack sleep, and previous evidence has shown sleep may give the brain a chance to clear out clumps of amyloid beta, unfortunately none have been able to confirm that sleep deprivation can cause dementia.
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According to a leading theory, proteins called amyloid beta and tau build up in the brain and choke nerve cell communication, setting the disease in motion years before people suspect anything is wrong with their recall.
But Holtzman and other researchers previously demonstrated that plaques of amyloid - beta protein build up faster in the brains of APOE4 carriers (SN: 7/30/11, p. 9).
Several factors have been implicated in Alzheimer's, including the build - up of an abnormal protein called beta amyloid, fibrous tangles in the brain involving abnormal forms of a protein called tau, and — most recently — an association between the disease and a gene called ApoE.
Building on this work, Ming, Darrell Cole Cerrato and colleagues at the University of South Florida wanted to find out if betanin, a beet compound used in commercial dyes that readily binds to metals, could block the effects of copper on beta - amyloid and, in turn, prevent the misfolding of these peptides and the oxidation of neurons.
They also showed in mice studies and in the laboratory that NCAM2 was broken down by another protein called beta - amyloid, which is the main component of the plaques that build up in the brains of people with the disease.
Researchers believe the disease progresses because of sticky clumps of beta - amyloid proteins that form and build up between neurons, eventually killing them.
Plaques are the build up of sticky proteins called beta amyloid, and tangles are twisted strands of a protein called tau.
To better explain this finding, the team turned to yet another protein, amyloid beta — which in its soluble form, before building up and hardening into plaques, has already been found to be toxic to the synapses.
The national, multicenter study confirms earlier findings suggesting that identifying silent beta - amyloid plaque build - up in the brain could help guide care and treatment decisions for patients at risk for Alzheimer's.
Hammer tweaked building blocks of amyloid - beta, synthesizing a nonsticky version of the amino acids that bind the proteins.
The test measures the relative amounts of different forms of beta - amyloid in blood to see whether plaques are likely to be building in the brain.
The condition is characterised by a build - up of a protein called beta - amyloid, which forms...
Presenilin can trim peptides into building blocks helpful to its own cells, or whittle bad peptide chunks that end up in amyloid - beta plaque, a suspect in Alzheimer's disease.
The researchers built on earlier research on the structure of beta - amyloid monomers done at the University of Chicago.
Amyloid beta may trigger tau build - up, which may in turn cause the disease, says Disterhoft.
Other studies identified additional ways to make the brain more resistant to amyloid - beta peptides that impair neuronal function as they build up in brains of those with Alzheimer's.
This is an interesting study building on recent evidence that sleep is important for clearing amyloid beta from the brain.
«In this study, Dr Shokri - Kojoriand colleagues examined the effect of sleep deprivation on the accumulation of amyloid beta, one of the pathologies that builds up in the brain of people with Alzheimer's disease.
Related studies have elucidated how proteins that build up to abnormally high levels in the brain of Alzheimer's patients — amyloid beta, tau and alpha - synuclein — interact to disrupt brain function and promote memory loss.
One of the early signs of Alzheimer's disease is the build - up of amyloid - beta fragments in a patient's brain.
More recently, as scientists realized that IDE was also involved in clearance of amyloid - beta, they have begun searching for ways to supercharge the enzyme to see if it could prevent the build - up of the amyloid plaques that are a hallmark of Alzheimer's disease.
During sleep, toxins that build up in the brain throughout the day called beta amyloid are cleared at a rate 10 times greater than during wakefulness.
It's believed that one benefit of sleep is to clear beta - amyloid, and poor sleep might allow it to build up, the authors of the new study pointed out.
A 2014 study published in the Journal of the American Medical Association discovered that people with high levels of bad cholesterol and low levels of good cholesterol had a higher chance of developing a build - up of beta - amyloid proteins in their brain, which are indications of Alzheimer's disease and dementia.
Deep sleep plays an important role in memory, and research shows that missing out on rest can contribute to a build up of beta - amyloid protein in the brain, associated with the development of Alzheimer's disease.
Alzheimer's disease, which is characterized by a loss in motor, psychological, and cognitive function, is attributed to the build up of beta - amyloid plaque surrounding neurons.
A plaque that builds up in the brain of Alzheimer's patients called beta - amyloid plaques is believed to be one of the primary causes of Alzheimer's disease.
The more often we don't get a good night's sleep, the more beta amyloid and tau proteins build up in our brains.
Studies have indicated that lithium may inhibit the build up of beta - amyloid and tau proteins, the main components of the plaques and tangles that form in the brain with Alzheimer's disease.