Sentences with phrase «amyloid formation»
"Amyloid formation" refers to the process in which proteins in the body clump together abnormally, forming structures called amyloid plaques. These plaques can accumulate in different organs or tissues, disrupting their normal function and potentially leading to various diseases, such as Alzheimer's or Parkinson's. Full definition
Additional experiments with cultured cells suggested that the mutation interferes with one of the enzymes that breaks down the APP protein and causes a 40 % reduction in β amyloid formation, Stefansson and colleagues report online today in Nature.
sciencemag.org
Biochemist Nigel Hooper of the University of Leeds in England and his colleagues found that high levels of normal prion proteins in human cells prevent beta - amyloid formation by inhibiting an enzyme called beta - secretase.
One of the hallmarks of Parkinson's disease is amyloid formation of a particular human protein, called alpha - synuclein.
In animal studies it seems that it may affect levels of cholesterol, which may serve as a potential modulator of Alzheimer - type amyloid formation.
Type 2 diabetes in cats (Diabetes mellitus) is associated with defective insulin secretion, insulin resistance and various cell changes, including amyloid formation which occurs.
Several of these changes increase β amyloid formation and cause a devastating inherited form of Alzheimer's that afflicts people in their 30s and 40s — much earlier than the far more common «late - onset» form of Alzheimer's that typically strikes people their 70s and 80s.
With time, the processes involved in amyloid formation can also destroy the ß beta cells of the cat's pancreas.
Then Juan de Pablo and Chi - Cheng Chiu from the University of Chicago's Institute for Molecular Engineering interpreted Zanni's measurements with data from molecular simulations to arrive at a complete picture of the early events leading to amyloid formation.
An investigator with the Howard Hughes Medical Institute, Weissman is a protein biochemist whose laboratory focuses on protein folding, amyloid formation and next - generation genomic sequencing.