Sentences with phrase «amyloid in human patients»

Regardless, simply through the demonstrated clearance of amyloid in human patients this is a big step forward for the field.

Not exact matches

Specifically, rodents genetically modified to express human amyloid precursor protein (hAPP), which can lead to the debilitating plaques that form in the brains of Alzheimer's patients, seem to struggle to find the hidden platform relative to their healthy peers.

Despite encouraging evidence from animal studies that it clears amyloid from the brain, when it came to clinical improvements in human patients the drug proved no better than placebo in two phase III clinical trials.

The good safety profile of Aducanumab in patients may well be attributed to the antibody's specific capacity to bond with the abnormally folded beta - amyloid protein fragment as well as the fact that the antibody is of human origin.

Therapies applying this paradigm to clear β - amyloid protein (Aβ) plaques and soluble aggregates from patients with Alzheimer's disease (AD) is an extremely active field of research, with multiple active and passive Aβ vaccines currently in human clinical trials.

In a human trial that has now lasted a year, this new immunotherapy cleared near all detectable amyloid - β from patients, and the patients showed improvement in the sense that their decline appeared to slow significantlIn a human trial that has now lasted a year, this new immunotherapy cleared near all detectable amyloid - β from patients, and the patients showed improvement in the sense that their decline appeared to slow significantlin the sense that their decline appeared to slow significantly.

Other studies have shown that dogs affected by this syndrome show deposition of amyloid (a protein) in their brains in patterns very similar to the amyloid plaques found in the brains of human Alzheimer's patients.