Sentences with phrase «amyloid reported»

Not exact matches

Merck is the latest company to weather bad news in the Alzheimer's drug race, halting a late - stage trial yesterday in an experimental amyloid - targeting candidate called verubecestat after a data monitoring committee said there was «virtually no chance of finding a positive clinical effect,» Reuters reported.

Most recently, he noted, researchers reported in Science that sleep functions as a kind of «sewer system» for the brain, at least in mice, by flushing beta - amyloid, which is known to accumulate in the brains of patients with Alzheimer's disease.

The UCLA researchers, led by David Eisenberg, director of the UCLA - Department of Energy Institute of Genomics and Proteomics and a Howard Hughes Medical Institute investigator, report the first application of this technique in the search for molecular compounds that bind to and inhibit the activity of the amyloid - beta protein responsible for forming dangerous plaques in the brain of patients with Alzheimer's and other degenerative diseases.

Combine your articles on psilocybin and other psychedelic drugs having beneficial effects on the brain (such as 25 November 2017, p 28) with the promising reports of 40 hertz bass tones and flickering lights reducing the tangles and plaques of tau and amyloid proteins that are correlated with Alzheimer's disease (6 January, p 6).

Amyloid — an abnormal protein whose accumulation in the brain is a hallmark of Alzheimer's disease — starts accumulating inside neurons of people as young as 20, a much younger age than scientists ever imagined, reports a surprising new Northwestern Medicine study.

Research by Finch's team in the mid -»90s also led to a startling discovery in Alzheimer's research: In 1998, working with neuroscientists at Northwestern University in Evanston, Illinois, the group reported that amyloid — the insoluble protein that piles up in the Alzheimer's - afflicted brain — is also highly neurotoxic when it clusters into small but soluble oligomers, dubbed ADDLs.

«This study has allowed us to sort out, in mice, which effects of the different types of APOE were most important to variation in amyloid plaque deposition,» says Eloise Hudry, PhD, of MGH - MIND, lead author of the Science Translational Medicine report.

In a study published in the journal Cell Reports, Drs. Per Nilsson, Takaomi Saido and their team show for the first time using transgenic mice that a lack of autophagy in neurons prevents the secretion of amyloid beta and the formation of amyloid beta plaques in the brain.

BUILDUP Amyloid - beta (brown) accumulated in the front of the brain in a person who received injections of cadaver - derived growth hormone as a child, suggesting that the injections were contaminated with A-beta, researchers reported this year.

But researchers in Italy and the United Kingdom reported in April that many different types of normal proteins — with no known link to diseases — can also fold into shapes indistinguishable from the dreaded amyloid fibrils.

The researchers found that reports of shorter sleep duration and poorer sleep quality were associated with a greater β - Amyloid burden, a hallmark of the disease.

And a landmark paper in 2013 reported that strains of amyloid - β with different 3D structures were associated with different disease progression in two people with Alzheimer's.

Ambrosia also reported a 20 per cent fall in the level of amyloids — a type of protein that forms sticky plaques in the brains of people with Alzheimer's disease.

And more direct evidence for its role in making plaques is the fact that cells produced more beta amyloid if they contained certain mutated forms of nicastrin, the researchers report in the 7 September issue of Nature.

They report that their method can reduce levels of amyloid - β, the prime suspect in Alzheimer's disease, by up to 50 % in the brains of mice.

The Zanello study also reports the presence of two indicators of optic nerve damage, glial fibrilar acidic protein (GFAP) and beta - amyloid.

In February a group of researchers from Case Western Reserve University reported online in Science that a cancer drug with relatively benign side effects was able to rapidly clear from the brains of mice toxic amyloid - beta protein fragments that accompany Alzheimer's.

Additional experiments with cultured cells suggested that the mutation interferes with one of the enzymes that breaks down the APP protein and causes a 40 % reduction in β amyloid formation, Stefansson and colleagues report online today in Nature.

Now one team, reporting in the journal ACS Chemical Neuroscience, has identified how amyloid beta, the protein fragment strongly associated with Alzheimer's disease, can induce cellular changes that might lead to Parkinson's.

With its report, the Harvard / MGH - led team is the first to show antimicrobial activity of amyloid - β in animals.

Previously, other researchers reported that ApoE4 seemed to reduce the clearance of amyloid - β, the protein that clumps together to form the hallmark plaques of AD, from the brain in a mouse model.

The researchers reported in the early online edition of Science on December 9, 2010, that the beta - amyloid production rate was similar between the 2 groups.

«This study is significant in that it reports the first measurement of beta - amyloid production and clearance in Alzheimer's,» says Dr. Marcelle Morrison - Bogorad, director of the Division of Neuroscience at NIH's National Institute on Aging (NIA).

We report that immunization of the young animals essentially prevented the development of beta - amyloid - plaque formation, neuritic dystrophy and astrogliosis.

PURPOSE: We had previously reported that certain of our murine (m) antihuman light chain monoclonal antibodies (mAbs) recognized an epitope common to AL and other types of amyloid fibrils.

In another study, those who reported SCI were also more likely to show changes in their brains on imaging scans, specifically demonstrating higher levels of beta - amyloid protein.

We report here that in vitro generated DS neural cells have abnormal metabolism of amyloid - β (Aβ) manifested by increased secretion and accumulation of Aβ granules of Aβ42 pathological isoform with upregulated expression of the APP gene.

To verify the effectiveness of aducanumab, a trial was set in place that involved 165 people receiving the drug and over the course of one year it was reported that the amyloid - beta levels in these people's brains had declined.

The present neuropathological study reports the second case of meningoencephalitis following immunization with amyloid - beta peptide in AD, and has been directed toward exploring mechanisms underlying decreased tau pathology in relation with amyloid deposit regression, and possible molecular bases involved in the inflammatory response following immunization.

«This study reports amyloid protein deposits in the blood vessels of four people decades after receiving brain surgery.

Lewis, who studies the effects of antiretroviral drugs on the cardiovascular system in his laboratory, reports that he came across the amyloid tissue sample as part of his duties as director of cardiovascular pathology: «It was beautiful.»

For example, in addition to asymmetric distribution of amyloid beta, which has been reported, the differences could reflect disease subtypes that affect hemispheres differently.»

And each and every trial has failed, with the most recent report in the New England Journal of Medicine showing that a drug, Semagacestat, designed to lower beta - amyloid, actually made people more demented and increased the risk for other threatening issues.

From that spinal fluid, the researchers found that people who reported poor sleep quality had, on average, more markers of Alzheimer's disease — including amyloid and tau buildups, brain - cell damage, and inflammation.