Sentences with phrase «analyses of gene sequence»

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In the study, whole - exome sequencing and a targeted analysis of 90 genes implicated in heart disease were applied to 419 unrelated SIDS cases.

Analysis of physical characteristics in three - dimensionally preserved Fukangichthys skulls, as well as an examination of DNA sequences from 12 genes, revealed that scanilepiforms are actually ancient cousins of polypterids.

Efforts are under way to close the remaining gaps; however, the sequence is of sufficient accuracy and contiguity to be declared substantially complete and to support an initial analysis of genome structure and preliminary gene annotation and interpretation.

However, the results of more recent phylogenetic analyses, derived from comparisons between sequences of specific genes and of whole genomes, seemed to point to Ctenophora as the first group that parted company with the lineage from which the rest of the animal kingdom (including sponges) evolved.

Sequence analysis of the virus revealed numerous genes previously thought to exist only in cellular organisms.

Using a combination of old - fashioned clinical observation and modern biochemical analysis, he has shown that a person's appetite and their eating behavior can be linked to specific genes — and that even a tiny defect such as the absence of a single nucleic acid in a sequence of DNA can lead to runaway weight gain.

Using metabolic function analyses of identified genes, we compared our human genome with the average content of previously sequenced microbial genomes.

The new analysis, based on data assembled primarily by graduate student Yan - Jie Feng at Sun Yat - Sen University in Guangzhou, China, focused on the sequences of 95 genes located on chromosomes in the nucleus and how they changed over time.

In - depth analysis of the human body's microflora has been possible only in the past few years — a by - product of the same new gene sequencing techniques that have allowed scientists to cheaply and accurately identify the DNA of the human genome.

Before the consortium came together, he had participated in sequencing the genomes of two vocal learners, a songbird and a parrot, but he knew he couldn't do all of the additional sequencing and analysis work that would be required to identify genes related to vocal learning — not by himself, at least — so he teamed up with Genome 10K, a project aiming to collect genomes for 10,000 vertebrate species.

Our RNA sequencing analysis of NAFLD - HCC samples revealed squalene epoxidase (SQLE) as the top outlier metabolic gene overexpressed in NAFLD - HCC patients.

Bioinformatic analysis of this sequence information was then able to pinpoint a gene that might have the appropriate activity to initiate hydrocarbon biosynthesis, Molnar said.

These tags are detected and measured using a sensitive DNA analysis technique known as massive, parallel sequencing, providing a quantitative readout of the gene's activity levels.

Computational genomics includes: bio-sequence analysis, gene expression data analysis, phylogenetic analysis, and more specifically pattern recognition and analysis problems such as gene finding, motif finding, gene function prediction, fusion of sequence and expression information, and evolutionary models.

Just as the Human Genome Initiative in the 1990s sequenced human DNA for the subsequent identification and analysis of genes, so too will the Materials Genome Initiative sequence materials for identifying new properties for a variety of applications.

Michael Metzker, at the time a graduate student in the laboratory of Richard Gibbs at Baylor College of Medicine in Houston, compared the gene sequences of the strains to see how closely related they were, using a technique called phylogenetic analysis.

With the aid of advanced gene sequencing, comparative DNA analysis, and endless cross-referencing of the genomes of organisms from the three — or perhaps four — domains of life, a fuller concept of viruses and their role in evolution has begun to coalesce.

First, samples of leaves from these plants are collected for in vitro cultures to isolate the fungi; then the DNA and RNA of fungi are extracted to sequence them and, through bioinformatic analysis, the researcher can determine the expression, the presence or absence of genes in the genomes of a species against each other.

In a similar case with a 12 - year - old whose exome was sequenced without any family data, Phevor built on the analysis of VAAST to identify a gene mutation causing the illness, another autoimmune syndrome.

An analysis of whole - genome sequences from more than 5,000 people has unearthed 18 new candidate genes for autism.

Bioinformatic approaches to the analysis of genetic variability and complex genotype - phenotype relationships will moreover include gene sequence and database analyses, measures of association of haplotypes / genotypes with phenotype, clustering procedures, neuronal networks, fuzzy and other techniques in pattern recognition, similarity measures for discrete patterns (e.g., gene sequences, structures, functions), logistic regression methods, and a spectrum of other techniques.

To this purpose, GenProfile utilizes a powerful technology platform, which involves proprietary high - throughput technologies for gene sequence comparison (e.g., multiplex sequence comparison), genotyping (MALDI - TOF minisequencing), unique approaches to data analysis and interpretation, as well as a large network of clinical collaborators.

This represents a particular challenge to disease gene analysis: How do we analyze genes and establish genotype - phenotype relationships against a background of high natural genome sequence variability?

GenProfile focuses on the systematic analysis of DNA sequence variation in biomedically relevant genes in order to identify those variants, or combinations of variants (gene profiles), that determine an individual's genetic risk for disease, predict individually different drug response, and ultimately pave the way to a personalized medicine.

A series of genetic analyses confirmed that the DNA target sequence had been altered in the transgenic plants, with either DNA insertions or deletions in both copies of the DFR - B gene (so - called bi-allellic mutants).

Additional funds will be needed to fine - tune the sequence and begin detailed analyses of the genes and their functions.

«We have developed a sophisticated statistical analysis software that permits us to localize the cancerous genes among the thousands of somatic mutations in the cancer DNA sequence,» answers Sergey Nikolaev.

Analysis of genomic, epigenetic, and RNA sequencing data revealed that the combinations of mutations that lowered the levels of functioning BRCA1 and BRCA2 RNA — genes that produce the breast cancer tumor suppressor proteins — were associated with significantly better survival outcomes.

The team also carried out a so - called metagenomic analysis, in which the genomes from all organisms in a sample are sequenced collectively; the great majority of genes they found coded for proteins never seen before.

In previous research, Grice and colleagues illuminated the great diversity of bacteria living on the skin using DNA - based sequence analysis of bacterial genes.

But because DNA sequencing is prone to errors, many of these variants are likely to be mistakes in gene analysis.

Deep sequencing analysis has shown that this is highly unlikely in the case of J3 as no sequences were generated by deep sequencing of the seven naïve llamas or three other immunized llamas that share greater identity with J3 than its putative germ line V gene.

According to Dr. Wong, «This combined strategy provides us with a new tool for reliable molecular analysis of any genes containing multiple copies of highly homologous sequences and should improve the positive finding rate for patients with Lynch syndrome if the PMS2 gene is suspected to be defective.

But after analyzing the Hofstenia transcriptome, the team determined that the three - banded panther worm and planarians are only very distantly related, a view that had been proposed based on analyses with sequences from a small number of genes.

M. P. Myers et al., «Positional cloning and sequence analysis of the Drosophila clock gene, timeless,» Science 270, 5237 (3 November 1995)

Analysis of the DNA and encoded amino acid sequences of A14 and B9 revealed that the first two are clonal variants which aligned most closely to the germ line denoted VHH Vg (T Verrips, unpublished data) and that the sequence of B21 is highly divergent from both and also aligns to a different germ line V gene sequence Vu.

Using this «Ribotag» approach tissue - specific changes under DR have been measured in muscle, fat, gut, heart, neurons, germline and malpighian tubules, showing a highly tissue specific response upon DR.. We are developing mechanistic models of gene expression regulation and conducting comprehensive bioinformatics analyses on UTRs, promoters and the coding sequences of various elements of differentially regulated genes.

«Such analyses could complement current risk assessment strategies of emerging influenza viruses, including viral genome sequencing and screening for alterations in known viral virulence genes.»

However, further sequencing analysis established that these germ line chimera were not present at the earlier time point, as no sequences with the fully mature DJ regions paired to the relevant germ line V genes were detected at t = 54 whereas between 50 and 250 copies of such clones were present at t = 174.

The majority of cases of Lynch syndrome are attributed to heterozygous germline mutations in the DNA mismatch repair genes MLH1 and MSH2, and current methods for DNA sequencing and deletion analysis can successfully detect these mutations.

(C) Analysis of the variable gene sequences from plasmablasts of the four pandemic H1N1 - infected patients indicated that ∼ 16.5 % of the pandemic H1N1 - induced plasmablasts were clonally related (shared identical VH and JH genes and CDR3 junctions).

Interestingly, the results of our promoter analysis for all these genes revealed that 9 of 17 genes (COL13A1, CSF3, FSCN1, HG18, LTBP1, PELI1, PLOD2, SCNN1A, and TNFSF10) have perfectly matched consensus sequences of KLF4 binding site on the promoter regions, suggesting a potential possibility of controlling these genes by KLF4 although it is not clear whether these genes are cause or consequence of brain metastasis at this point.

Our guest published a historic paper less than one month ago (available here), describing the first comprehensive study of an individual, combining genomic (genome sequence), transcriptomic (genes turned on / off), proteomic (the total complement of proteins - or protein profiles), metabolomic (complete metabolic analysis), and autoantibody profiles.

Sequencing accelerates the analysis of cancer associated alterations in genome sequence such as insertions and deletions, CNVs, inversions, duplications, translocations and gene fusions, as well as single nucleotide variants.

g (acceleration due to gravity) G (gravitational constant) G star G1.9 +0.3 gabbro Gabor, Dennis (1900 — 1979) Gabriel's Horn Gacrux (Gamma Crucis) gadolinium Gagarin, Yuri Alexeyevich (1934 — 1968) Gagarin Cosmonaut Training Center GAIA Gaia Hypothesis galactic anticenter galactic bulge galactic center Galactic Club galactic coordinates galactic disk galactic empire galactic equator galactic habitable zone galactic halo galactic magnetic field galactic noise galactic plane galactic rotation galactose Galatea GALAXIES galaxy galaxy cannibalism galaxy classification galaxy formation galaxy interaction galaxy merger Galaxy, The Galaxy satellite series Gale Crater Galen (c. AD 129 — c. 216) galena GALEX (Galaxy Evolution Explorer) Galilean satellites Galilean telescope Galileo (Galilei, Galileo)(1564 — 1642) Galileo (spacecraft) Galileo Europa Mission (GEM) Galileo satellite navigation system gall gall bladder Galle, Johann Gottfried (1812 — 1910) gallic acid gallium gallon gallstone Galois, Évariste (1811 — 1832) Galois theory Galton, Francis (1822 — 1911) Galvani, Luigi (1737 — 1798) galvanizing galvanometer game game theory GAMES AND PUZZLES gamete gametophyte Gamma (Soviet orbiting telescope) Gamma Cassiopeiae Gamma Cassiopeiae star gamma function gamma globulin gamma rays Gamma Velorum gamma - ray burst gamma - ray satellites Gamow, George (1904 — 1968) ganglion gangrene Ganswindt, Hermann (1856 — 1934) Ganymede «garbage theory», of the origin of life Gardner, Martin (1914 — 2010) Garneau, Marc (1949 ---RRB- garnet Garnet Star (Mu Cephei) Garnet Star Nebula (IC 1396) garnierite Garriott, Owen K. (1930 ---RRB- Garuda gas gas chromatography gas constant gas giant gas laws gas - bounded nebula gaseous nebula gaseous propellant gaseous - propellant rocket engine gasoline Gaspra (minor planet 951) Gassendi, Pierre (1592 — 1655) gastric juice gastrin gastrocnemius gastroenteritis gastrointestinal tract gastropod gastrulation Gatewood, George D. (1940 ---RRB- Gauer - Henry reflex gauge boson gauge theory gauss (unit) Gauss, Carl Friedrich (1777 — 1855) Gaussian distribution Gay - Lussac, Joseph Louis (1778 — 1850) GCOM (Global Change Observing Mission) Geber (c. 720 — 815) gegenschein Geiger, Hans Wilhelm (1882 — 1945) Geiger - Müller counter Giessler tube gel gelatin Gelfond's theorem Gell - Mann, Murray (1929 ---RRB- GEM «gemination,» of martian canals Geminga Gemini (constellation) Gemini Observatory Gemini Project Gemini - Titan II gemstone gene gene expression gene mapping gene pool gene therapy gene transfer General Catalogue of Variable Stars (GCVS) general precession general theory of relativity generation ship generator Genesis (inflatable orbiting module) Genesis (sample return probe) genetic code genetic counseling genetic disorder genetic drift genetic engineering genetic marker genetic material genetic pool genetic recombination genetics GENETICS AND HEREDITY Geneva Extrasolar Planet Search Program genome genome, interstellar transmission of genotype gentian violet genus geoboard geode geodesic geodesy geodesy satellites geodetic precession Geographos (minor planet 1620) geography GEOGRAPHY Geo - IK geologic time geology GEOLOGY AND PLANETARY SCIENCE geomagnetic field geomagnetic storm geometric mean geometric sequence geometry GEOMETRY geometry puzzles geophysics GEOS (Geodetic Earth Orbiting Satellite) Geosat geostationary orbit geosynchronous orbit geosynchronous / geostationary transfer orbit (GTO) geosyncline Geotail (satellite) geotropism germ germ cells Germain, Sophie (1776 — 1831) German Rocket Society germanium germination Gesner, Konrad von (1516 — 1565) gestation Get Off the Earth puzzle Gettier problem geyser g - force GFO (Geosat Follow - On) GFZ - 1 (GeoForschungsZentrum) ghost crater Ghost Head Nebula (NGC 2080) ghost image Ghost of Jupiter (NGC 3242) Giacconi, Riccardo (1931 ---RRB- Giacobini - Zinner, Comet (Comet 21P /) Giaever, Ivar (1929 ---RRB- giant branch Giant Magellan Telescope giant molecular cloud giant planet giant star Giant's Causeway Giauque, William Francis (1895 — 1982) gibberellins Gibbs, Josiah Willard (1839 — 1903) Gibbs free energy Gibson, Edward G. (1936 ---RRB- Gilbert, William (1544 — 1603) gilbert (unit) Gilbreath's conjecture gilding gill gill (unit) Gilruth, Robert R. (1913 — 2000) gilsonite gimbal Ginga ginkgo Giotto (ESA Halley probe) GIRD (Gruppa Isutcheniya Reaktivnovo Dvisheniya) girder glacial drift glacial groove glacier gland Glaser, Donald Arthur (1926 — 2013) Glashow, Sheldon (1932 ---RRB- glass GLAST (Gamma - ray Large Area Space Telescope) Glauber, Johann Rudolf (1607 — 1670) glaucoma glauconite Glenn, John Herschel, Jr. (1921 ---RRB- Glenn Research Center Glennan, T (homas) Keith (1905 — 1995) glenoid cavity glia glial cell glider Gliese 229B Gliese 581 Gliese 67 (HD 10307, HIP 7918) Gliese 710 (HD 168442, HIP 89825) Gliese 86 Gliese 876 Gliese Catalogue glioma glissette glitch Global Astrometric Interferometer for Astrophysics (GAIA) Global Oscillation Network Group (GONG) Globalstar globe Globigerina globular cluster globular proteins globule globulin globus pallidus GLOMR (Global Low Orbiting Message Relay) GLONASS (Global Navigation Satellite System) glossopharyngeal nerve Gloster E. 28/39 glottis glow - worm glucagon glucocorticoid glucose glucoside gluon Glushko, Valentin Petrovitch (1908 — 1989) glutamic acid glutamine gluten gluteus maximus glycerol glycine glycogen glycol glycolysis glycoprotein glycosidic bond glycosuria glyoxysome GMS (Geosynchronous Meteorological Satellite) GMT (Greenwich Mean Time) Gnathostomata gneiss Go Go, No - go goblet cell GOCE (Gravity field and steady - state Ocean Circulation Explorer) God Goddard, Robert Hutchings (1882 — 1945) Goddard Institute for Space Studies Goddard Space Flight Center Gödel, Kurt (1906 — 1978) Gödel universe Godwin, Francis (1562 — 1633) GOES (Geostationary Operational Environmental Satellite) goethite goiter gold Gold, Thomas (1920 — 2004) Goldbach conjecture golden ratio (phi) Goldin, Daniel Saul (1940 ---RRB- gold - leaf electroscope Goldstone Tracking Facility Golgi, Camillo (1844 — 1926) Golgi apparatus Golomb, Solomon W. (1932 — 2016) golygon GOMS (Geostationary Operational Meteorological Satellite) gonad gonadotrophin - releasing hormone gonadotrophins Gondwanaland Gonets goniatite goniometer gonorrhea Goodricke, John (1764 — 1786) googol Gordian Knot Gordon, Richard Francis, Jr. (1929 — 2017) Gore, John Ellard (1845 — 1910) gorge gorilla Gorizont Gott loop Goudsmit, Samuel Abraham (1902 — 1978) Gould, Benjamin Apthorp (1824 — 1896) Gould, Stephen Jay (1941 — 2002) Gould Belt gout governor GPS (Global Positioning System) Graaf, Regnier de (1641 — 1673) Graafian follicle GRAB graben GRACE (Gravity Recovery and Climate Experiment) graceful graph gradient Graham, Ronald (1935 ---RRB- Graham, Thomas (1805 — 1869) Graham's law of diffusion Graham's number GRAIL (Gravity Recovery and Interior Laboratory) grain (cereal) grain (unit) gram gram - atom Gramme, Zénobe Théophile (1826 — 1901) gramophone Gram's stain Gran Telescopio Canarias (GTC) Granat Grand Tour grand unified theory (GUT) Grandfather Paradox Granit, Ragnar Arthur (1900 — 1991) granite granulation granule granulocyte graph graph theory graphene graphite GRAPHS AND GRAPH THEORY graptolite grass grassland gravel graveyard orbit gravimeter gravimetric analysis Gravitational Biology Facility gravitational collapse gravitational constant (G) gravitational instability gravitational lens gravitational life gravitational lock gravitational microlensing GRAVITATIONAL PHYSICS gravitational slingshot effect gravitational waves graviton gravity gravity gradient gravity gradient stabilization Gravity Probe A Gravity Probe B gravity - assist gray (Gy) gray goo gray matter grazing - incidence telescope Great Annihilator Great Attractor great circle Great Comets Great Hercules Cluster (M13, NGC 6205) Great Monad Great Observatories Great Red Spot Great Rift (in Milky Way) Great Rift Valley Great Square of Pegasus Great Wall greater omentum greatest elongation Green, George (1793 — 1841) Green, Nathaniel E. Green, Thomas Hill (1836 — 1882) green algae Green Bank Green Bank conference (1961) Green Bank Telescope green flash greenhouse effect greenhouse gases Green's theorem Greg, Percy (1836 — 1889) Gregorian calendar Grelling's paradox Griffith, George (1857 — 1906) Griffith Observatory Grignard, François Auguste Victor (1871 — 1935) Grignard reagent grike Grimaldi, Francesco Maria (1618 — 1663) Grissom, Virgil (1926 — 1967) grit gritstone Groom Lake Groombridge 34 Groombridge Catalogue gross ground, electrical ground state ground - track group group theory GROUPS AND GROUP THEORY growing season growth growth hormone growth hormone - releasing hormone growth plate Grudge, Project Gruithuisen, Franz von Paula (1774 — 1852) Grus (constellation) Grus Quartet (NGC 7552, NGC 7582, NGC 7590, and NGC 7599) GSLV (Geosynchronous Satellite Launch Vehicle) g - suit G - type asteroid Guericke, Otto von (1602 — 1686) guanine Guiana Space Centre guidance, inertial Guide Star Catalog (GSC) guided missile guided missiles, postwar development Guillaume, Charles Édouard (1861 — 1938) Gulf Stream (ocean current) Gulfstream (jet plane) Gullstrand, Allvar (1862 — 1930) gum Gum Nebula gun metal gunpowder Gurwin Gusev Crater gut Gutenberg, Johann (c. 1400 — 1468) Guy, Richard Kenneth (1916 ---RRB- guyot Guzman Prize gymnosperm gynecology gynoecium gypsum gyrocompass gyrofrequency gyropilot gyroscope gyrostabilizer Gyulbudagian's Nebula (HH215)

High quality of DNA / RNA products is the foundation of successful cancer research such as analysis of genetic alterations, gene expression profiling and next generation sequencing.

We helped with the analysis of targeted 3730 sequencing of some candidate genes in a warfarin patient cohort, and uncovered another gene, (CALU, encoding calumenin) in which variants influenced warfarin dose.

Applying Nanopore Sequencing and Real - Time Antimicrobial Resistance Gene Analysis to Address the Threat of Carbapenem - Resistant Gram - Negative Organisms

James Giovannoni generated the gene expression data through RNA - sequencing and Lukas Mueller provided additional analysis to confirm the quality of the genome assembly.

It currently analyses a panel of multiple cancer predisposition genes thanks to new - generation sequencing techniques.