In the first study (Klaassen et al., 2008) mutational
analysis in a large cohort of 63 unrelated adult probands with LVNC and absence of other congenital heart anomalies was performed.
Saturday, Oct. 21, 9:45 - 10:45 a.m., Room 330A, South Building Platform Session: Advancing Drug Discovery by Genetic
Analysis in Large Cohorts Moderator: Dana Crawford, Case Western Reserve University
Not exact matches
Most studies of homebirth
in other countries have found no statistically significant differences
in perinatal outcomes between home and hospital births for women at low risk of complications.36, 37,39 However, a recent study
in the United States showed poorer neonatal outcomes for births occurring at home or
in birth centres.40 A meta -
analysis in the same year demonstrated higher perinatal mortality associated with homebirth41 but has been strongly criticised on methodological grounds.5, 42 The Birthplace
in England study, 43 the
largest prospective
cohort study on place of birth for women at low risk of complications, analysed a composite outcome, which included stillbirth and early neonatal death among other serious morbidity.
An UpToDate review on «Planned home birth» (Declercq and Stotland, 2015) stated that «
Large cohort studies using intent - to - treat
analysis of midwife - attended, planned, out - of - hospital birth of low - risk women
in developed countries have reported reduced rates of cesarean birth, perineal lacerations, and medical interventions, and similar rates of maternal and early perinatal morbidity and mortality compared to planned hospital birth.
Together, the results of the well - controlled observational studies20 - 23 (including ours), the
analysis of
cohorts without social patterning of breastfeeding (eg,
in the Pelotas
cohort), 24 and the
large randomized trial25 suggest that confounding does not account fully for the observed association of breastfeeding with later cognition.
The Chronic Hepatitis
Cohort Study is an
analysis of records from a
large, geographically and racially diverse group of 9,783 patients receiving care at four
large U.S. health systems: Henry Ford Health System
in Detroit; Kaiser Permanente Northwest
in Portland, Oregon; Kaiser Permanente
in Honolulu and Geisinger Health System
in Danville, Pennsylvania.
«Our
analysis of three
large U.S.
cohorts including persons
in whom diabetes has been diagnosed shows those who were at target levels for HbA1c, blood pressure and LDL to have substantially lower risks for cardiovascular disease than persons with diabetes who were not at target levels for such factors,» Wong said.
Researchers expect the data presented
in this study to fuel the formation of
large national and international research consortiums to conduct comprehensive, systematic
analysis of inherited (germline) genome data
in large cohorts of uveal melanoma patients.
The Columbia researchers with colleagues
in Finland conducted an
analysis of data from the Finnish Prenatal Study of Schizophrenia, a
large, national birth
cohort with an extensive bio-bank.
Dr. Polonis» lab has focused for many years on functional antibodies elicited by natural infection and by vaccination, utilizing samples from multiple natural history
cohorts and vaccine studies; her lab is currently performing an extensive
analysis of pseudovirus neutralizing antibodies
in the
large RV144 follow - on trial, RV306.
It allows the
analysis of host immune gene expression
in relation to vaccination, infection, disease or therapy
in larger cohorts.
As recently shown
in a collaborative
analysis of 10
large cohort studies, women appear to feature more often the metabolically healthy obese phenotype with normoglycemia and without dyslipidemia and hypertension (7 % — 28 %) compared with males (2 % — 19 %)(39).
The prevalence of metabolic syndrome and metabolically healthy obesity
in Europe: a collaborative
analysis of ten
large cohort studies
Since 1997, he has directed the investigation of neurodegenerative diseases
in the Nurses» Health Study and other
large cohorts comprising more than 400,000 men and women who have provided detailed information on their dietary habits and lifestyle
in addition to blood or cheek cell samples for genetic and other laboratory
analyses.
For meaningful scientific interpretation of histopathological data through
analysis of
large cohorts of mice, we recommend, 24 mice per age group (i.e., number used
in systematic clinical tests).
Analysis of
larger cohorts will provide information about the frequency and kinetics of PARPi reversion mutations
in this patient population.
BLASTing the 15 - bp PORE sequence revealed a
large cohort of genes potentially regulated by such a mechanism (although osteopontin, the one target gene previously known to be regulated by a PORE sequence, was not identified
in this
analysis).
Our bioinformatics
analysis, based on multiple independent
large - size
cohorts shows that MELK is strongly overexpessed
in BBC / TNBC, not only compared to normal breast tissues, but also compared to luminal or ER / PR + breast cancer.
However, the point estimates suggest that prebiotic consumption, especially GOSs, might be associated with a lower risk of depression; therefore, it would be of great interest to replicate these
analyses in a
cohort with a
larger number of incident cases of depression to increase the statistical power.
«His meta -
analysis of the cutting - edge research on
large -
cohort studies of what sugar does to populations across the world, alongside his own clinical observations, has him credited with starting the war on sugar,» writes Zoe William
in The Guardian.
Analyses were conducted using public - use data available from the Fragile Families and Child Wellbeing Study, a prospective birth
cohort study that follows up a nationally representative sample of children from 20
large cities
in the United States.