The secondary
analysis suggested a dose - response relationship, such that higher vericiguat doses were associated with greater reductions in NT - proBNP level.
Not exact matches
These results remained largely unchanged after further sensitivity
analyses, prompting the researchers to
suggest that giving moderate to higher opioid
doses for shorter durations may be a more effective way to manage pain after surgery, while minimising the risk of misuse and addiction.
The authors
suggest that for the future «A more complete clinical
analysis should entail follow - up for at least 2 or 3 years and with an increased
dose range; such a design presumably would reveal the impact of
dose on both acute and late RT - related toxicity and thereby strengthen the associations observed in this
analysis of acute effects.»
While many researchers believe the transition from an anoxic world to an oxic world occurred gradually, Joe Kirschvink (Caltech) and I have
suggested instead — based on a critical
analysis of the available data, with a strong
dose of caution applied to the use of uniformitarian interpretations in such a radically different world — that the transition occurred rapidly (Kopp et al., 2005; Kirschvink and Kopp, 2008).
A 2014 meta -
analysis of 15 studies evaluating the role of coffee consumption in fracture risk
suggested that daily consumption of coffee is associated with an increased risk of fractures in women in a
dose dependent fashion and a contrasting decreased risk in men8.