This work shows the power of using the tools of computational genomics to
analyze gene expression patterns for the purpose of elucidating the evolution of behavior.
Recent advances in the understanding of cancer have led to more personalized therapies, such as drugs that target particular proteins and tests that
analyze gene expression patterns in tumors to predict a patient's response to therapy.
Not exact matches
In collaboration with Yi Xing from UCLA, the team catalogued and
analyzed how
gene expression patterns in skin cells differed among the Esrp knockouts and found hundreds of significant changes.
In collaboration with Prof. Ido Amit of Weizmann's Immunology Department, they
analyzed the genomes of 1,500 individual liver cells, establishing
patterns of
expression for about 20,000
genes in each cell.
Gene expression profiling tests, such as Oncotype Dx,
analyze the
patterns of 21 different
genes within cancer cells to help predict how likely it is that a women's cancer will recur within 10 years after initial treatment and how beneficial chemotherapy will be to her.
To understand and
analyze the regulation of
gene expression patterns, quantitative RNA sequencing is used.
Using genechip technology, a powerful tool for
analyzing the
expression patterns of thousands of
genes at a time, researchers have identified a number of
genes that are specifically regulated by the...
The process used by NIH to select the mouse lines involved a rigorous scientific review process that evaluated information on the knocked out
gene, the reliability of the method used to produce the knockout, and whether the mouse line possesses a «reporter»
gene, which enables researchers to
analyze the
pattern of the knockout
gene's
expression in various mouse tissues.
A reliability score is set manually for all
genes and indicates the level of reliability of the
analyzed protein
expression pattern based on available protein / RNA /
gene characterization data from both HPA and the UniProtKB / Swiss - Prot database.
Moreover, when
analyzed with
gene expression patterns of normal brain cells, the four GBM subtypes associate with different cell lineages.
Analyzing patterns of
gene expression in individual human immune system cells, the researchers refined the definitions of the types known as dendritic cells and monocytes and identified a novel type that had been overlooked.
A reliability score is set for all
genes and indicates the level of reliability of the
analyzed protein
expression pattern based on available protein / RNA /
gene characterization data.
In 2005, a team of researchers at the Spanish National Cancer Research Centre led a study that
analyzed DNA methylation
patterns to see how they affected
gene expression in identical twins ranging in age from 3 to 74.