Sentences with phrase «analyze tumor samples»

To search for other characteristics of ccRCC tumors that influences immunotherapy response or resistance, the researchers used whole - exome DNA sequencing to analyze tumor samples from 35 patients treated in a clinical trial with the checkpoint blocker nivolumab (Opdivo).

Grading is judged by a pathologist, after analyzing a tumor sample under the microscope.

Not exact matches

The focus of those hopes is the liquid biopsy: a test that could detect and analyze a solid tumor from biomarkers in the bloodstream or other easily sampled body fluids, such as saliva.

While the latter has a reputation for being hard to isolate, she explains that even degraded RNA generally contains enough intact sequence to analyze — provided investigators can detect the scarce tumor signals against the immense background of other RNA molecules in a sample.

This study analyzed preserved tumor samples from 43 prostate cancer patients who later received radiation therapy after rising PSA levels were detected following a radical prostatectomy.

Analyzing a database of nearly 800 multiple myeloma patient samples, they discovered that 162 patients with low ADAR1 levels in their tumor cells survived significantly longer over a three - year period compared to 159 patients with high ADAR1 levels.

The researchers analyzed the samples using immunohistochemistry and RNA sequencing to study the changes in the tumor immune microenvironment of patients who received and did not receive chemotherapy, and changes before and after chemotherapy.

The researchers next will turn to analyzing the presence of myoferlin in samples from numerous human tumor types available in an Ohio State tissue bank, which will allow them to compare protein levels in tumors to clinical outcomes for the patients who provided the samples.

The research team analyzed BRAF inhibitor resistance in melanoma cell lines, mice bearing human melanoma tumors, and in human tumor biopsy samples.

They analyzed bacterial DNA found in breast tissue samples from 58 women who were undergoing lumpectomies or mastectomies for either benign or cancerous tumors, as well as from 23 healthy women who had undergone breast reductions or enhancements.

Samples of the tumor are excised, examined under a microscope and, often, analyzed to pinpoint the genetic mutations responsible for the malignancy.

Using all the existing data that was available, Andrechek, along with MSU doctoral student Daniel Hollern, analyzed 1,172 mouse mammary tumor samples from 26 different preclinical models and was able to compile one of the largest databases to show which strains of mice were best suited to study a particular type of human breast cancer.

Analyzing the poly - G profiles of primary and metastatic colon cancer samples from 22 patients revealed that how the primary and metastatic tumors related to each other was different for each patient.

Answering important clinical questions — such as whether genetic diversity is a risk factor for aggressive tumor development or how it relates to treatment resistance — requires analyzing samples from many patients with different types of cancer.

An additional set of 18 prostate cancer tissue samples was analyzed by qPCR and five lncRNAs were found to be significantly higher in prostate tumor tissues compared with matched normal tissues.

In collaboration with Dr. Omer Iqbal, from the Department of Pathology, they are analyzing the genetics and biology of tumor samples to find how they differ from samples of tumors not linked to radiation.

Fifteen teams analyzed nearly 500 patients» tumors for genetic aberrations and sequenced the protein - coding DNA of 316 samples — by far the largest cancer sequencing effort to date.

Charles Swanton, a cancer geneticist at the Francis Crick Institute in London, and colleagues analyzed 1,206 clear - cell renal cell carcinoma (ccRCC) tumor samples from 101 patients as part of the Tracking Cancer Evolution through therapy (TRACERx) program.

In order to test whether the method is suitable for use in clinical routine diagnostics, the scientists analyzed more than 1,100 additional tumor samples.

To that end, Sharma gave an overview of MD Anderson's efforts to comprehensively characterize the activity of the immune cells in the patients they treat, and they've already analyzed over 42,000 tumor tissue samples, from both before and after treatment, looking for clues regarding how treatment outcomes relate to immune cell infiltration into tumors.

After more than a year of planning, the project had an easy - to - use, online consent form in which MBC patients could agree to share medical records, treatment history and tumor tissue and donate saliva samples (allowing researchers to analyze both their cancerous tumors and noncancerous cells).

Through her CLIP Grant, she is analyzing patient samples to determine how Poly ICLC (a TLR agonist) affects the tumor environment and immune responses against specific mutations, to identify how Poly ICLC could complement existing immunotherapies.

The first manuscript entitled, Circulating Free Tumor - derived DNA (ctDNA) Determination of EGFR Mutation Status in Real - World European and Japanese Patients with Advanced NSCLC: the ASSESS Study, used samples from the large ASSESS study to evaluate EGFR mutation status by analyzing ctDNA from blood plasma.

University of Hawai'i Cancer Center researchers developed a computational algorithm to analyze «Big Data» obtained from tumor samples to better understand and treat cancer.

Their work encompasses several strategies, including: developing FL - HCC animal models to characterize tumor - immune interactions, exploring if a mutated protein associated with FL - HCC could be targeted by immunotherapy, identifying immune checkpoints that could potentially serve as targets for immunotherapy as well as biomarkers for analyzing patients, and evaluating the effectiveness of immunotherapy strategies against FL - HCC patient samples in the lab.

To develop the methodology, the group analyzed the molecular profiles of human embryonic stem cells and compared them with data for 12,000 samples of 33 different tumor types held by The Cancer Genome Atlas (TCGA), a U.S. public database.

Laser Light Test Reveals Spreading Cancer Cancer imaging and breast cancer experts used advanced microscopes equipped with tissue - penetrating laser light to develop a promising new way to accurately analyze the distinctive patterns of ultra-thin collagen fibers in breast tumor tissue samples and to help tell if the cancer has spread.

Since completing the initial paper published Thursday, the team has analyzed 50 more samples from eye fluid of retinoblastoma patients, including those with less aggressive tumors whose eyes were saved, to get a start on determining what factors might be at play in tumor progression.

When the researchers sequenced the samples for genetic mutations and analyzed chromosome structure, they could trace the tumors» evolutionary histories, much as evolutionary biologists trace the origins of organisms back to their common ancestors based on fossils deposited in different geologic eras.

Next, a biopsy or tissue sample of the tumors, or any excessive fluids that have collected in body cavities, may be taken and analyzed.

Radiographs of the chest and back will be analyzed to screen for tumors or other damage to the skeletal system, and a sample of the fluid surrounding the spinal cord may be collected for analysis.

They also found that just over half the tumors samples analyzed carry genetic mutations that could be targeted by therapies that are already on the market.