After
analyzing brain tissue samples, the researchers identified an area of the gene where a single change reduced BDNF levels in the hypothalamus, a key area that controls eating and body weight.
Not exact matches
Over the course of three years, Horvath and his team
analyzed nearly 8,000
tissue samples from these datasets, which included blood, saliva and cells from organs like the
brain and the colon.
Finally, the researchers
analyzed samples of human
brain tissue from patients with Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis and multiple sclerosis.
Once testing was complete,
brain images,
tissue and blood
samples were used to
analyze changes to
brain structure and cytokine activity (proteins released by the immune system to help fight off infections or diseases).
The researchers
analyzed the concentrations of 5,713 different lipids, or fat molecules and their derivatives, present in
samples of
brain, kidney and muscle
tissues taken from humans, chimpanzees, macaques and mice.