«We have identified novel molecular features in diverse cell types using a new strategy of
analyzing hundreds of cells individually,» said Arnold Kriegstein, MD, PhD, director of the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF.
Not exact matches
Figure on the left:
Analyzing the relative sensitivity
of hundreds of cancer
cell lines to commonly used anti-cancer drugs (each dot) reveals that
cells with suppressed expression
of one proteasome cap subunit are specifically resistant to treatments with the proteasome inhibitors MG132 and bortezomib.
In collaboration with Yi Xing from UCLA, the team catalogued and
analyzed how gene expression patterns in skin
cells differed among the Esrp knockouts and found
hundreds of significant changes.
Researchers at Rice University's Laboratory for Systems Biology
of Human Diseases
analyzed the metabolic profiles
of hundreds of ovarian tumors and discovered a new test to determine whether ovarian cancer
cells have the potential to metastasize.
The power
of loops Using sophisticated algorithms to
analyze the
hundreds of millions — in some cases, billions —
of contact points in these
cells, Aiden and his colleagues could see that these genomes pinch off into some 10,000 loops.
Using machine learning technology, the researchers
analyzed hundreds of existing datasets from six different
cell types to look for patterns in the genome that identify where a gene and enhancer interact.
After
analyzing 964 sites cleaved in vitro by different 11 sgRNAs and measuring indel frequencies at
hundreds of off - target sites in
cells, we propose an off - target scoring system
of each target site for minimizing CRISPR - Cas9 off - target effects in the human genome.
Using sophisticated algorithms to
analyze the
hundreds of millions — in some cases, billions —
of contact points in these
cells, Aiden and his colleagues could see that these genomes pinch off into some 10,000 loops.