(
anaplastic astrocytoma in the cerebellum and brain stem)
The patients in this landmark clinical study included two female children with nonresectable advanced stage brain tumors (
anaplastic astrocytoma stage IV, and cerebellar astrocytoma stage III).
TEMODAR is indicated for the treatment of adult patients with refractory
anaplastic astrocytoma, i.e., patients who have experienced disease progression on a drug regimen containing nitrosourea and procarbazine.
«High grade glioma» can include: Glioblastoma multiforme (WHO grade IV);
Anaplastic astrocytoma (WHO grade III); Anaplastic oligodendroglioma (WHO grade III); and Anaplastic ependymoma (WHO grade III).