On the other hand, we suspect that PCBs could provoke cancer through several mechanisms, which include the
interaction with estrogen and
androgen hormone
receptors, the production of free radicals, or with DNA.
At SAGE KE (http://www.sciencemag.org/sciext/drugdisc/#insageke), Raber describes the role of isoform - dependent
interactions of apoE with
androgens and
androgen receptors in the progression of Alzheimer's disease.