Sentences with phrase «androgen receptors on»

Ketoconazole attaches to androgen receptors on hair follicles and thus, prevents the receptors from interacting with the hormone dihydrotestosterone (DHT).

Flutamide blocks androgen receptors on hair follicle cells so androgens can't connect to the receptors.

Not exact matches

«It is telling us that the pesticides most prevalent in the human population have effects on the androgen receptor,» said Zoeller, who directs the university's Laboratory of Molecular, Cellular and Developmental Endocrinology.

On the other hand, we suspect that PCBs could provoke cancer through several mechanisms, which include the interaction with estrogen and androgen hormone receptors, the production of free radicals, or with DNA.

A search of the CRISP database of NIH - funded research projects on three key words — mutant, androgen, and receptor — yields 24 projects funded since 1999 by nine different NIH institutes: the National Cancer Institute (eight projects), the National Institute of General Medical Sciences (NIGMS, three projects), the National Institute of Child Health and Human Development (three projects), the National Institute of Diabetes and Digestive and Kidney Diseases (two projects), and the National Center for Research Resources (two projects).

I work in hearing research, and I am now working on genes that are linked to blood (platelet) disorders as well as with mouse models expressing mutant steroid (androgen) receptor genes.

Interestingly, the drug enzalutamide is in wide use for prostate cancer, which tends to be driven by and dependent on androgen receptor.

«But what we show is that even triple negative breast cancers with lower androgen receptor expression critically depend on the androgen receptor and may benefit from anti-androgen receptor therapy.

Rosenfeld's group went on to find that these cytokines trigger a relay team of molecules to alter the androgen receptor.

The new research found that on top of their known effects on cancer, Hsp90 inhibition also blocked production of abnormal forms of the androgen receptor, stripping cancer cells of their defences against hormone treatments.

However, cancer cells often generate abnormal forms of the androgen receptor that can be switched on all the time without the need for androgen hormone stimulation.

Inhibition of cell migration and invasion of enzalutamide - resistant prostate cancer cells was effected by niclosamide through its effects on the androgen receptor (AR)- STAT3 signaling axis [40].

Mechanisms behind the consequences of castration resulting in endogenous androgen withdrawal were explained by effects on NO production, which is higher if testosterone is absent, and the endothelin B receptor, which may be directly influenced by testosterone and causes vasoconstriction.

Labbé, D. P. and Nowak, D. G. and Deblois, G. and Lessard, L. and Giguère, V. and Trotman, L. C. and Tremblay, M. L. (2014) Prostate cancer genetic - susceptibility locus on chromosome 20q13 is amplified and coupled to androgen receptor - regulation in metastatic tumors.

We are currently trying to identify the membrane receptors that mediate rapid effects of androgens and estrogens on behavioral and physiological processes related to courtship in goldfish, as well as to determine if these steroids rapidly affect early stages of sensory processing in ways that amplify neural responses to social stimuli.

In this study, we focused on PC3 cells, which lack androgen receptor expression, are completely undifferentiated, are highly tumorigenic and metastatic, and have been considered the most malignant prostate cancer cell line (27 — 29).

«The androgen (male hormone) receptors on the scalp becoming activated,» explains Mark Hammonds, MD, a dermatologist with Scott & White Clinic in Round Rock, Texas.

Not only do these signals tell the hypothalamus when it is time to release stimulating hormones, but testosterone also stimulates androgen receptors in the brain that turn on pleasure sensations.

In addition, not only are some of them estrogen mimickers, but others will suppress your enzymatic activity necessary to produce androgen hormones, while other will block the receptor sites on the cell.

In humans, L - carnitine helps to increase the growth of muscle cell fibers by increasing energy production within cells and by increasing the number of androgen receptor sites on the muscle cell surface, which in turn increases the level of circulating testosterone.

There are at least 24,000 androgen receptor binding sites on the human genome.