Sentences with word «anergy»

Signaling through CD28 and CTLA - 4 controls two distinct forms of T cell anergy.
Noteworthy is that «Another possible explanation for why late introduction of cereal grains was associated with wheat allergy is that when wheat is introduced to an older child, it tends to be introduced in greater amounts.18 We can speculate that a large antigen load may have resulted in T - cell activation instead of anergy or tolerance.»
If it does, then you might use the approach of making more beta cells right at early onset of the type 1 disease to try and stop or reverse the immune attack, making the immune system think its made a mistake, inducing something called anergy by making more beta cells.
The authors suggest that MSC are most likely inducing the alternative condition of divisional arrest anergy in T cells, an occurrence usually associated with CTLA - 4 signalling 135.
Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation.
Eva Guinan, M.D. Harvard Medical School Dana Farber Cancer Institute Extending the donor pool by inducing alloantigen specific T - cell anergy ex vivo for human hematopoietic stem cell transplantation
Or the system can force harmful immune cells to commit suicide or to go into a dysfunctional stupor called anergy.
Using transplantable tumor models expressing antigen in an inducible manner or spontaneous tumor models expressing nominal antigens, we try to decipher whether the tumor is ignored or leads to deletion, anergy or class switch of the specific immune response or generate suppressor T cells.
These include T - cell depletion by apoptosis; anergy (ie, the process by which T cells that are presented with a peptide in the absence of costimulatory signals become refractory to further stimulation with the antigen and are therefore inactivated); and the development of regulatory T cells, which can actively suppress antigen - specific responses following re-challenge with the antigen.
Combination OX40 agonism / CTLA -4 blockade with HER2 vaccination reverses T - cell anergy and promotes survival in tumor - bearing mice.
Inhibition or deficiency in this pathway leads to T cell anergy, despite the presence of costimulation (53).
His research includes, uncovering the complex transcriptional network that exists in the tumor microenvironment roles of cancer initiating cells in immune suppresion, understanding the mechanism of T cell anergy and molecular analysis of T cell repertoire of patients with breast cancer.
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