The F1 hybrid mice are typically mated to C57BL / 6J (Stock No. 000664) mice to produce
the aneuploid embryos.
The rate of
aneuploid embryos resulting in miscarriage increases dramatically with maternal age such that 50 % or more of pregnancies after age 40 will miscarry.
A few
aneuploid embryos continue development and result in clinical problems.
In the embryology lab, at the earliest days of embryo development, most of
these aneuploid embryos don't develop, and are never seen clinically.
Examples of
aneuploid embryos include trisomy 18 and trisomy 21, otherwise known as Down Syndrome.
Not exact matches
PGS helps identify
embryos that are chromosomally abnormal, or
aneuploid.
Half or more (sometimes all)
embryos in a particular IVF treatment cycle are
aneuploid, and while we can't prove this, we suspect that the majority of natural conceptions are affected by aneuploidy as well.
The only way to tell if an
embryo is
aneuploid is to test.
In a woman under age 30, half of
embryos are
aneuploid.
An
embryo that carries an abnormal number of chromosomes is «
aneuploid».
«Our D7
embryos were also more likely to be
aneuploid,» said Dr. Han.