Sentences with phrase «aneuploid with»

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The rate of aneuploid embryos resulting in miscarriage increases dramatically with maternal age such that 50 % or more of pregnancies after age 40 will miscarry.

In a retrospective analysis of clinical trial data, they found that melanoma patients with highly aneuploid tumors were less likely to benefit from immune checkpoint blockade therapy than patients whose tumors showed fewer chromosomal disruptions.

Pre-malignant aneuploid cells grew more slowly and formed smaller tumors than comparable cells with normal chromosome number.»

Mice were infected with the aneuploid strains via intranasal instillation and monitored for signs of pulmonary cryptococcosis or meningoencephalitis.

Consistent with the observed consequences of aneuploidy in S. cerevisiae, all aneuploid C. neoformans strains in our study exhibited a TS phenotype (Figure 3A).

We have also identified a transcriptional signature of aneuploidy that is associated with cellular stress and slow proliferation, and is found in aneuploid primary and cancer cells across a host of organisms.

Moreover, many human tumors have highly abnormal numbers of chromosomes (that is, they are aneuploid), with initial chromosomal loss participating in the early steps of the transformation cascade in inherited cancers caused by heterozygous mutation in tumor suppressor genes and the more widespread aneuploidy characteristic of advance tumors thought to drive acquisition of malignant growth properties.??

Cole Laboratory publishes new paper in Cell (10/19/2017)- Chromosome mis - segregation creates cells with the wrong number of chromosomes (aneuploid cells).

By identifying phenotypes that are shared among tumors with different aneuploidies, we hope to discover pathways that can be manipulated to selectively eliminate aneuploid cells or to block aneuploidy's non-cell autonomous effects.

Pre-malignant aneuploid cells grew more slowly and formed smaller tumors than comparable cells with normal chromosome number, CSHL researchers found...

Leishmania, a major protozoan parasite, is emerging as a new model for aneuploidy, since in vitro - cultivated strains are highly aneuploid, with interstrain diversity and intrastrain mosaicism.

We are particularly interested in the mechanism of chromosome pairing and the quality control of the crossover formation process, and we aim to understand how the formation of gametes with abnormal / aneuploid genome is minimized in mammals.