Sentences with word «aneuploidy»

Prof. Dr. Rudi Balling, director of LCSB, explains the medical implications of the new insights: «We have long known of aneuploidy in multicellular organisms.

Consistent with the observed consequences of aneuploidy in S. cerevisiae, all aneuploid C. neoformans strains in our study exhibited a TS phenotype (Figure 3A).

Heitman is currently looking for aneuploidy in samples from the outbreak of Cryptococcus gattii in the western part of North America to see if it can explain how this sister strain of Cryptococcus neoformans has come to infect otherwise healthy individuals.

PGS for gay couples helps determine if any of the embryos have extra or missing chromosomes, known as aneuploidy, or if any chromosomes have translocated, which means a piece of a chromosome has broken off and reattached itself to a different part of the chromosome or even to another chromosome.

Sometimes, parents with aneuploidy pass it on to their children.

Half or more (sometimes all) embryos in a particular IVF treatment cycle are aneuploid, and while we can't prove this, we suspect that the majority of natural conceptions are affected by aneuploidy as well.

In 1914 Boveri observed that sea urchin embryos with abnormal amounts of chromosomal material, a condition called aneuploidy, looked cancerous.

Partly based on his MIT Ph.D. thesis research performed in yeast, Sheltzer suspects aneuploidy causes errors in DNA replication, as well as problems with chromosome segregation during cell division.

The researchers also investigated the impact of aneuploidy on other biological pathways, such as transcription, the first stage of gene expression in which a segment of DNA is copied into RNA.

Here we present the global overview of pre-test counseling importance in the context of prenatal aneuploidy screening by cffDNA with special emphasis on patients» experiences and choices in the tertiary teaching university hospital which provides cffDNA screening free of charge for all high - risk pregnancies and personal non-directive counseling.

The newly published experiments suggest the relation between aneuploidy and cancer is more complex than previously believed.

INVESTIGATIONAL STUDY OF A PRENATAL DIAGNOSTIC TEST FOR FETAL ANEUPLOIDY (PROTOCOL TT - 001)(Private)

As the eggs age, most suffer from aneuploidy, the uneven division of the chromosomes.

In gametes (eggs and sperm), chromosome mis - segregation can lead to human aneuploidies like trisomy 21 that causes Down syndrome.

Association between maternal characteristics, abnormal serum aneuploidy analytes, and placental abruption.

In the new study, published yesterday in PLOS Biology, Heitman and colleagues set out to explore whether genetically identical, unisexually reproducing C. neoformans cells were using aneuploidy to generate offspring that differed from themselves.

«These novel algorithms of identifying tumor suppressors and oncogenes nicely provide an explanation of how aneuploidies evolve in cancer cells, and the realization that subtle changes in the activity of many different genes at the same time can contribute to tumorigenesis is an exciting and intriguing hypothesis.»

«But in the cells that started out aneuploid — with a single extra chromosome — these cells now exhibited different aneuploidy once their rapid growth spurt began,» Sheltzer says.

Remarkably, the short - term presence of cells with supernumerary centrosomes in PLK4OE / p53cKO mice was sufficient to generate aneuploidy in the adult epidermis and triggered spontaneous skin cancers with complete penetrance.

In the new study, a team led by cancer geneticist Nazneen Rahman of the Institute of Cancer Research in Sutton, U.K., screened the DNA of eight families with mosaic variegated aneuploidy (MVA)-- a genetic disorder in which more than 25 % of a patient's cells are aneuploid and childhood cancers occur much more frequently than normal.

It is common for cancer researchers to apply high coverage to tumor samples to mitigate some of the challenges introduced by heterogeneity (the presence of contaminating DNA from multiple genomes within a sample) and gross aneuploidy (widespread copy - number changes).

In our lab, we are interested in the mechanisms at play when aneuploidy and polyploidy are induced in cycling cells in vivo.

The team found that high - aneuploidy tumors had increased expression of genes implicated in DNA replication, cell cycle, mitosis, and chromosome maintenance, yet decreased expression of genes characteristic of the infiltrating immune cells responsible for tumor destruction.

ART - 0006: MELISSA STUDY: MATERNAL BLOOD IS SOURCE TO ACCURAT ELY DIAGNOSE FETAL ANEUPLOIDY NESTED CASE: CONTROL ANALYSES T (Private)

Here we use two different mutant conditions to address the consequences of aneuploidy during tissue development and homeostasis in Drosophila.

Advances in technology have allowed cell - free DNA testing to move beyond aneuploidy testing to include sub-chromosomal conditions and monogenic disorders, but these tests are far from perfect and still require validation and proper implementation.

Aneuploidy occurs when parts of chromosomes beyond the normal 46 are missing or added to a person's genetic material during cell division.

Preimplantation genetic screening for aneuploidy at our Virginia fertility center can help hopeful parents avoid passing debilitating genetic disorders to their children.

Preimplantation genetic screening for aneuploidy allows physicians and laboratory technicians to identify genetically normal embryos that are more likely to result in a healthy baby.

It's probably a significant underestimate, since most aneuploidies abort early in pregnancy.

Full aneuploidy is unusual under age 30, but afflicts a third of cycles over age 40.

Although aneuploidy does not bring in new genetic sequences, it does make possible another kind of genetic diversity — in which the extra genes produce extra proteins, resulting in an organism that differs from its parents.

But in a paper published in the journal Cell, researchers at the Koch Institute for Integrative Cancer Research at MIT reveal that aneuploidy alone can cause this significant variability in traits, in otherwise genetically identical cells.

Aneuploidy originates during cell division, when the chromosomes do not separate properly or are not equally partitioned between the two daughter cells.

Because aneuploidy and chromosomal abnormalities are commonly observed in cancer, the researchers looked for evidence of DNA damage in the fused clones.

Such variations, named aneuploidies, are similar to those occurring in many cancer types.

«The organization of cell colonies and phenotypic switching between different types of colonies becomes a lot more flexible and rapid with reversible aneuploidy than if it depended on random mutations in the genes,» Skupin says.

Many believed aneuploidy was simply a random byproduct of cancer.

If having one extra chromosome caused an anti-tumorigenic effect in pre-malignant cells, then perhaps aneuploidy was not, in itself, a direct cause of cancer.

These findings also may have answered a long - standing question about whether aneuploidy is a cause or effect of cancer, leaving researchers free to pursue the question of how.

Elledge argues that simply losing or gaining one copy of a gene through aneuploidy can influence tumor growth as well.