148/5: 15 Complex mitotic - origin
aneuploidy in human embryos: Genetic risk factors and fertility consequences.
Remarkably, the short - term presence of cells with supernumerary centrosomes in PLK4OE / p53cKO mice was sufficient to generate
aneuploidy in the adult epidermis and triggered spontaneous skin cancers with complete penetrance.
Global analysis of genome, transcriptome and proteome reveals the response to
aneuploidy in human cells.
Consistent with the observed consequences of
aneuploidy in S. cerevisiae, all aneuploid C. neoformans strains in our study exhibited a TS phenotype (Figure 3A).
Heitman is currently looking for
aneuploidy in samples from the outbreak of Cryptococcus gattii in the western part of North America to see if it can explain how this sister strain of Cryptococcus neoformans has come to infect otherwise healthy individuals.
The paper «Non-canonical function of SAC proteins after APC activation reduces
aneuploidy in mouse oocytes» is published in the journal Nature Communications and was funded by the Australian Research Council.
Prof. Dr. Rudi Balling, director of LCSB, explains the medical implications of the new insights: «We have long known of
aneuploidy in multicellular organisms.
Given the rapid succession of generations in yeast, we can use it as a model organism — and study the mechanisms of
aneuploidy in much greater detail to find out whether we can derive from it new approaches for diagnosing and treating human diseases.»
PFC offers CCS as an option for patients undergoing in vitro fertilization (IVF), as a treatment for recurrent miscarriage, prevention of
aneuploidy in pregnancy, and for women that wish to improve implantation rates, reduce miscarriage rates, and reduce the risk of multiple pregnancy after IVF.
Aneuploidy in a baby can result in miscarriage or death shortly after birth.
Not exact matches
Aneuploidy is a genetic abnormality that can result
in pregnancy loss or a child with severe physical or mental disabilities.
Preimplantation genetic screening for
aneuploidy allows physicians and laboratory technicians to identify genetically normal embryos that are more likely to result
in a healthy baby.
It's probably a significant underestimate, since most
aneuploidies abort early
in pregnancy.
Half or more (sometimes all) embryos
in a particular IVF treatment cycle are aneuploid, and while we can't prove this, we suspect that the majority of natural conceptions are affected by
aneuploidy as well.
Several researchers interviewed, after asking to go off the record, erupted
in venomous attacks on Duesberg, saying that
aneuploidy is the result of cancer, not the cause.
In 1914 Boveri observed that sea urchin embryos with abnormal amounts of chromosomal material, a condition called
aneuploidy, looked cancerous.
In 2005 Duesberg was invited by the National Institutes of Health — which had long since dismissed him and his research — to give a grand rounds presentation on his
aneuploidy work.
Since his appointment at the University of Heidelberg
in 1997, Duesberg has spent each of the last 10 summers
in Mannheim down the hall from Hehlmann, conducting experiments
in cancer and
aneuploidy.
But recently a number of mainstream scientists have come around, agreeing that
aneuploidy may play a role (even if not an exclusive one)
in cancer.
In the new study, published yesterday in PLOS Biology, Heitman and colleagues set out to explore whether genetically identical, unisexually reproducing C. neoformans cells were using aneuploidy to generate offspring that differed from themselve
In the new study, published yesterday
in PLOS Biology, Heitman and colleagues set out to explore whether genetically identical, unisexually reproducing C. neoformans cells were using aneuploidy to generate offspring that differed from themselve
in PLOS Biology, Heitman and colleagues set out to explore whether genetically identical, unisexually reproducing C. neoformans cells were using
aneuploidy to generate offspring that differed from themselves.
Although
aneuploidy does not bring
in new genetic sequences, it does make possible another kind of genetic diversity —
in which the extra genes produce extra proteins, resulting
in an organism that differs from its parents.
I'm studying how changes
in chromosome number (a condition known as
aneuploidy) affect cell physiology and cancer progression.
Sexual reproduction can result
in a condition called
aneuploidy,
in which the offspring have extra copies of certain chromosomes.
The researchers also investigated the impact of
aneuploidy on other biological pathways, such as transcription, the first stage of gene expression
in which a segment of DNA is copied into RNA.
Disorders caused by
aneuploidy are unusual
in that the severity of their effects often varies widely from one individual to another.
But
in a paper published
in the journal Cell, researchers at the Koch Institute for Integrative Cancer Research at MIT reveal that
aneuploidy alone can cause this significant variability
in traits,
in otherwise genetically identical cells.
Aneuploidy is a condition
in which cells contain an abnormal number of chromosomes, and is known to be the cause of many types of cancer and genetic disorders, including Down Syndrome.
Because
aneuploidy and chromosomal abnormalities are commonly observed
in cancer, the researchers looked for evidence of DNA damage
in the fused clones.
Such variations, named
aneuploidies, are similar to those occurring
in many cancer types.
Today
in the journal Cancer Cell, Cold Spring Harbor Laboratory (CSHL) Fellow Jason Sheltzer, Ph.D., and colleagues at CSHL and MIT report surprising results of experiments intended to explore the consequences of having too many or too few chromosomes, a phenomenon that biologists call
aneuploidy (AN - you - ploid - ee).
Aneuploidy is also a leading cause of miscarriage, and with an estimated 1
in 7 pregnancies resulting
in miscarriage.
The role of
aneuploidy —
in which entire chromosomes or chromosome arms are added or deleted — has remained largely unstudied.
«The organization of cell colonies and phenotypic switching between different types of colonies becomes a lot more flexible and rapid with reversible
aneuploidy than if it depended on random mutations
in the genes,» Skupin says.
If having one extra chromosome caused an anti-tumorigenic effect
in pre-malignant cells, then perhaps
aneuploidy was not,
in itself, a direct cause of cancer.
Scientists from the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg,
in collaboration with colleagues from the US Institute for Systems Biology (ISB)
in Seattle, have now systematically studied the genetics of this process, which biologists refer to as
aneuploidy.
The team's new insights will allow a new medical evaluation of
aneuploidy, which is associated with certain diseases when it occurs
in multicellular organisms.
Partly based on his MIT Ph.D. thesis research performed
in yeast, Sheltzer suspects
aneuploidy causes errors
in DNA replication, as well as problems with chromosome segregation during cell division.
In humans,
aneuploidy is the leading cause of birth defects, miscarriage, and mental retardation.
In this context, telomerase activity can have unfavorable effects: «We found that this enzyme allows cells with
aneuploidy to bypass the protective function of telomeres.
In 1914, German biologist Theodor Boveri postulated that abnormal chromosome number, or
aneuploidy, might be a root cause of cancer.
Until now, one of the only ways of screening eggs or embryos for
aneuploidy was to use a technique called fluorescence
in - situ hybridisation (FISH),
in which specific chromosomes are stained with small pieces of fluorescent DNA to...
Aneuploidy is known to be deleterious and underlies several common human diseases, including cancer and genetic disorders such as trisomy 21
in Down's syndrome.
Aneuploidy evokes transcriptomic and proteomic changes
in the model yeast Saccharomyces cerevisiae [8], [10].
Aneuploidy is well known to be deleterious
in humans, causing genetic disorders like Down's syndrome or trisomy 21.
Aneuploidy was also detected
in progeny from a-α opposite - sex congenic mating; thus, both homothallic and heterothallic sexual reproduction can generate phenotypic diversity de novo.
An increasing body of work shows that similarly complex
aneuploidy variations play a role
in some forms of cancer and we think that the rapid accumulation of NGS genomics data combined with novel
in - silico techniques - like the ones developed
in our study - will soon lead to a better understanding of the relationships between
aneuploidy and allele selection».
We show here that unisexual, meiotic reproduction
in C. neoformans results
in aneuploidy, creating advantageous genetic diversity de novo.
In contrast to the view that aneuploidy is deleterious, the aneuploid unisexually generated isolates MN35 (n +113) and MN55 (n +19) were as virulent as the euploid wild - type parent, despite their modest TS growth at 37 °C on YPD rich media in vitro (Figure 7
In contrast to the view that
aneuploidy is deleterious, the aneuploid unisexually generated isolates MN35 (n +113) and MN55 (n +19) were as virulent as the euploid wild - type parent, despite their modest TS growth at 37 °C on YPD rich media
in vitro (Figure 7
in vitro (Figure 7).
Aneuploidy is responsible for the observed phenotypic changes, as chromosome loss restoring euploidy results
in a wild - type phenotype.
In contrast, aneuploidy can also be advantageous and in fungi confers antifungal drug resistance and enables rapid adaptive evolutio
In contrast,
aneuploidy can also be advantageous and
in fungi confers antifungal drug resistance and enables rapid adaptive evolutio
in fungi confers antifungal drug resistance and enables rapid adaptive evolution.