Sentences with phrase «aneuploidy on»

Our model should allow studies of the impact of aneuploidy on molecular adaptations and cellular fitness.IMPORTANCE Aneuploidy is usually detrimental in multicellular organisms, but in several microorganisms, it can be tolerated and even beneficial.

Using Plk4 overexpression (PLK4OE) during epidermal development, we assess the impact of centrosome amplification and aneuploidy on skin development and tumorigenesis.

The researchers also investigated the impact of aneuploidy on other biological pathways, such as transcription, the first stage of gene expression in which a segment of DNA is copied into RNA.

Not exact matches

Depending on the genes that are missing or duplicated, some people can survive with aneuploidy.

However, even when survival is possible, aneuploidy can have a significant impact on a person's intelligence, health and lifespan.

Several researchers interviewed, after asking to go off the record, erupted in venomous attacks on Duesberg, saying that aneuploidy is the result of cancer, not the cause.

In 2005 Duesberg was invited by the National Institutes of Health — which had long since dismissed him and his research — to give a grand rounds presentation on his aneuploidy work.

The cells» response to environmental changes also varied considerably, suggesting that aneuploidy has an impact on the robustness of many, if not all, biological processes.

«The organization of cell colonies and phenotypic switching between different types of colonies becomes a lot more flexible and rapid with reversible aneuploidy than if it depended on random mutations in the genes,» Skupin says.

Partly based on his MIT Ph.D. thesis research performed in yeast, Sheltzer suspects aneuploidy causes errors in DNA replication, as well as problems with chromosome segregation during cell division.

In contrast to the view that aneuploidy is deleterious, the aneuploid unisexually generated isolates MN35 (n +113) and MN55 (n +19) were as virulent as the euploid wild - type parent, despite their modest TS growth at 37 °C on YPD rich media in vitro (Figure 7).

My post-doctoral work on the identification of genes required for normal germ line development and fertility led to the discovery that the germ line is exquisitely sensitive to mutations in components of the mitotic spindle that have the potential to lead to aneuploidy — this sensitivity may also extend to embryonic and adult stem cells.

«The authors went on to study the resulting blastocysts for aneuploidy (frequency of abnormal chromosomes), and pattern of gene expression (which genes are active and at what level).

The team's work highlights this by presenting a comprehensive view of genome evolution on many different levels (e.g., differences in ploidy, aneuploidy, genetic variants, hybridization, and introgressions) that is difficult to obtain at the same scale and accuracy for other eukaryotic organisms.

9: Aneuploidy and Ploidy in the Endosperm: Dosage, Imprinting, and Maternal Effects on Development

The alternation of two life stages in different environments (extracellular promastigotes and intracellular amastigotes) offers a unique opportunity to study the impact of environment on aneuploidy and gene expression.

The method provides quantitative aneuploidy calls, and is integrated into an R software package available on GitHub and as an Additional file of this manuscript.

[1] Tarin J J. Aetiology of age — associated aneuploidy: A mechanism based on the «free radical theory of ageing».

Today academic institutions and teaching hospitals across the country receive federal or private grants to support groundbreaking research using human fetal tissue on a wide range of conditions including diabetes, Parkinson's disease, Alzheimer's disease, spinal cord injuries, hemophilia, leukemia, sickle cell anemia, cortical blindness, fetal aneuploidy, ALS, and others.