Sentences with phrase «aneuploidy tumors»

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A high degree of aneuploidy is a feature of high - grade tumors and is associated with poor prognosis.

Many tumors are characterized by «aneuploidy,» meaning they display an abnormal number of chromosomes and chromosomal segments.

«Unfortunately our paper suggests that tumors don't even need to be heterogeneous genetically, the very fact that they have aneuploidy could lead to very variable outcomes, and that represents a significant challenge for cancer therapy,» Amon says.

Elledge argues that simply losing or gaining one copy of a gene through aneuploidy can influence tumor growth as well.

Aneuploidy (an abnormal number of chromosomes) is the most common genetic alteration in human tumors and a major cause for birth defects (Figure 4).

Errors in chromosome segregation are a major cause for birth defects and embryonic lethality in humans, and the most common genetic alteration in human tumors is aberrant chromosome numbers, called aneuploidy.

Errors in chromosome segregation can cause birth defects and embryonic lethality in humans and cause aneuploidy, the most common genetic alteration in tumors.

The efficient compaction of DNA during cellular division ensures equal distribution of DNA into daughter cells and prevents aneuploidy, which has been implicated as a major driver of tumor development.

This case includes the majority of tumor samples and perhaps genomes with mosaic aneuploidy.

Moreover, many human tumors have highly abnormal numbers of chromosomes (that is, they are aneuploid), with initial chromosomal loss participating in the early steps of the transformation cascade in inherited cancers caused by heterozygous mutation in tumor suppressor genes and the more widespread aneuploidy characteristic of advance tumors thought to drive acquisition of malignant growth properties.??

Using a series of genetically - matched euploid and aneuploid cell lines, we have demonstrated that aneuploidy can paradoxically function as a barrier to tumor growth.

By identifying phenotypes that are shared among tumors with different aneuploidies, we hope to discover pathways that can be manipulated to selectively eliminate aneuploid cells or to block aneuploidy's non-cell autonomous effects.

Nearly all tumors exhibit a condition known as aneuploidy — their cells contain the wrong number of chromosomes.

About 90 % of solid tumors display whole - chromosome aneuploidy, while many tumors with diploid karyotypes nonetheless harbor segmental or arm - length aneuploidies that also result in significant gene copy number alterations.

Swanton's new lab set out to identify specific genes that, when inhibited, result in the death of tumor cells that displayed aneuploidy, meaning they had more or less than the normal set of 46 chromosomes.