Sentences with word «angiogenesis»

Peter Carmeliet: «Our discovery opens up a whole new domain for inhibition of angiogenesis in various diseases such as cancer.

Physicians use special inhibitors called angiogenesis inhibitors to «starve» tumors.

Teodoro JG, Evans SK and Green MR. Inhibition of tumor angiogenesis by p53: a new role for the guardian of the genome.

Results from recent clinical trials and studies in animals suggest that a class of anti-cancer drugs called angiogenesis inhibitors may be able to temporarily reduce interstitial pressure and improve the efficacy of chemotherapy and radiation treatments.

The chicken chorioallantoic membrane (CAM) assay was used to determine the ability of kahweol to inhibit angiogenesis in vivo.

Together, they confirmed the importance of Wars2 for angiogenesis in rats and zebrafish.

Inhibition of cell proliferation and in vitro markers of angiogenesis by indole -3-carbinol, a major indole metabolite present in cruciferous vegetables.

Blood vessel development is technically known as angiogenesis, so the drugs that inhibit this process are called antiangiogenic.

I am not sure about overdosing on angiogenesis inhibitors.

Before his death, Folkman began to explore treatments with angiogenesis inhibitors for conditions as seemingly disparate as myocardial infarction, diabetes, macular degeneration, and even obesity [4].

Chronic experimental hypoxia kills photoreceptors in adult rat retina [14] and can lead to retinal angiogenesis [15].

«Finding a way to control angiogenesis not only provides a target for the development of anti-cancer therapies, but may also prove useful in similarly starving abnormal blood vessel growth elsewhere in the body, like in diabetic eye disease.»

Pericyte Tie2 controls sprouting angiogenesis in in vitro sprouting and in vivo spheroid assays.

Chwalek K, Tsurkan MV, Freudenberg U, Werner C. Glycosaminoglycan - based hydrogels to modulate heterocellular communication in in vitro angiogenesis models Scientific Reports 4, 4414 (8pp)(2014)

Drugs developed for more familiar inflammatory diseases may also fight cancer — and these medicines might be combined into HIV - like drug cocktails that also include angiogenesis inhibitors and cell - killing agents.

If you irradiate a tissue with a short laser pulse, the part with abnormal angiogenesis will absorb more laser energy than the surrounding tissues and produce a different acoustical signature.

If you wanted a good food for stopping the DHA — angiogenesis pathway, you've found it: tomatoes.

Moderate omega - 3 consumption is especially important for those suffering from diseases of pathological angiogenesis — especially cancer.

Tissue - engineered 3D tumor angiogenesis models: Potential technologies for anti cancer drug discovery.

These results indicate that the application of porous films stimulates angiogenesis through improving the body's self - healing capacity.

Angiopoietin - 2 differentially regulates angiogenesis through TIE2 and integrin signaling.

They first induced angiogenesis in mice through the injection of a growth factor called FGF - 2 and measured blood vessel development in the presence and absence of synthesised IP5.

In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia, tumor suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4].

More directly, a 2009 study in the Journal of Nutrition, found that turmeric prevents fat cell differentiation, causes fat cell apoptosis (cell destruction), and further reduces the formation of fat cells by preventing angiogenesis (the growth of blood vessels needed to support new fatty tissues in your body).

-- Naringin is an inhibitor of vascular endothelial growth factor (VEGF) release, which causes angiogenesis (formation of new blood vessels)(4).

A clinical, contemporary example of a multidisciplinary mind is Judah Folkman, the pioneer of angiogenesis research.

[8] Therapies targeting angiogenesis were introduced in early 2003 with trials of inhibitors of VEGF - R2 and its ligand, VEGF, as well as the downstream mediator, mTOR.

These findings led us to investigate the roles of S1P in tumor microenvironment, and found that S1P promote not only angiogenesis, but also lymphangiogenesis and lymph node metastasis of breast cancer (Nagahashi M et al, Cancer Research 2012).

Bevacizumab, the first angiogenesis inhibitor approved by the FDA, is in use now to treat colon cancer.

This is very different mechanism of action than other agents that also effect angiogenesis by inhibiting vascular endothelial growth factor (VEGF) such as bevacizumab (Avastin; Genentech).

Treated mice formed fewer tumors and showed less angiogenesis, and half survived to day 40, whereas all untreated mice died within 30 days, the group reports in Science.

Neurospheres from these patients also showed impairment of the ability to create new vessels, with low concentration of VEGFA, one of the most important angiogenesis regulatory molecules, and increased concentration of TIMP - 1, an antiangiogenic protein.

Because the majority of angiogenesis regulatory factors appear to be sequestered in platelets, which possess the ability to selectively accumulate these factors in patients with cancer, they have the potential to detect tumor growth before it is clinically apparent.

Curcumin also stops angiogenesis, which is the way tumors create their own blood supply.