Sentences with phrase «angiogenesis models»

Tissue - engineered 3D tumor angiogenesis models: Potential technologies for anti cancer drug discovery.

Glycosaminoglycan - based hydrogels to modulate heterocellular communication in in vitro angiogenesis models.

We show for the first time that kahweol is an anti-angiogenic compound with inhibitory effects in two in vivo and one ex vivo angiogenesis models, with effects on specific steps of the angiogenic process: endothelial cell proliferation, migration, invasion and tube formation on Matrigel.

Not exact matches

«Using a novel model we developed to facilitate discoveries about the growth and spread of lymph node metastases, we show that angiogenesis does not occur in lymph node metastases, providing a mechanism for resistance to angiogenic therapy in these situations.»

In the mouse model, treating node metastases with two angiogenesis inhibitors that have different mechanisms of action did not change the density of blood vessels or the growth of the metastases.

We are actively engaged in advancing novel methods to image molecular events in both humans and animal models that include receptor expression, proliferation, angiogenesis, and apoptosis.

Research Interests: Inflammatory bowel disease (IBD); Crohn's disease; ulcerative colitis; animal models of IBD; mucosal T - cell death and survival; tolerance to gut microbiota; interactions between immune and non-immune cells; immune - driven angiogenesis and lymphangiogenesis; intestinal fibrosis; intestinal myofibroblasts, extracellular matrix; systems biology; complex diseases

Eph receptor and ephrin ligand signalling has been implicated in vascular development and in in vivo models of angiogenesis where bi-directional signalling mediates juxtracrine cell — cell contact, cell adhesion to extracellular matrix and cell migration30, 31,32.

Furthermore, this compound displayed promising properties by impairing CXCR4 function in three mouse models: paw inflammation, Matrigel plug angiogenesis, and uveal melanoma micrometastasis.

This hypothesis is corroborated by animal studies showing that angiogenesis was negatively influenced by estrogen loss in oophorectomized animals (290), whereas estrogen therapy induced collateral and microvascular remodeling in a similar animal model (291).

C) Angiogenesis assay in the zebrafish model.

On the other hand, the present research work shows a confirmatory evidence of the potential of kahweol to inhibit in vivo angiogenesis, by using another completely independent model system, namely, that of genetically modified zebrafish.

A third line of evidence showing the potential of kahweol to inhibit overall angiogenesis is provided by the ex vivo model of the mouse aortic ring assay.

Thaker PH, Han LY, Kamat AA, et al: Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma.