Sentences with word «angiogenic»

According to experts, by modulating the secretion of angiogenic factors in ovarian cancer cells, ginger is can be one of the most potent natural ingredients against this disease.

Indeed, not all tumours have the same aggressiveness, nor the same angiogenic capacity; it was therefore a question of observing whether the recruitment of these cells took place differently, depending on the type of malignant cells involved.

To explain the so - called angiogenic switch, or sudden growth of new blood vessels, some have pointed to endothelial progenitors, which live in bone marrow but are found in more than half of all solid tumor types, says hematology oncologist Shahin Rafii of Weill Cornell Medical College in New York City.

But, it was known that when HIF - 1 normally activates signals in the body to build new vessels, one of the many types of cells recruited to the site of new vessel growth is a population of stem cells from the bone marrow, which are called bone marrow - derived angiogenic cells.

A particular subpopulation of monocytes has angiogenic properties that enables vascularization.

When the researchers treated the mice with both the HIF - 1 virus and simultaneously injected bone marrow - derived angiogenic cells, treated, older mice were less likely to lose their legs compared to their untreated counterparts.

«It is particularly important because ccRCC is well known for being a very angiogenic cancer.

«Using a novel model we developed to facilitate discoveries about the growth and spread of lymph node metastases, we show that angiogenesis does not occur in lymph node metastases, providing a mechanism for resistance to angiogenic therapy in these situations.»

With greatly increased porosity, the newly developed porous films demonstrated about five times greater angiogenic capability compared to conventional porous films.

Dr Sidibé describes how: «The ability of tumours to recruit angiogenic monocytes is due to the ability of the tumours themselves to produce cytokines.

PDGFb, secreted by angiogenic EC, acts as the best characterized growth factor recruiting PDGFRb expressing pericytes7.

Collectively, the experiments identified a more angiogenic and leaky, yet well perfused vasculature in tumours of mice with targeted deletion of Tie2 in pericytes.

Niclosamide inhibits the inflammatory and angiogenic activation of human umbilical vein endothelial cells.

A major aspect of this process is the production of multiple angiogenic cytokines and growth factors in response to hypoxia / ischemia, which is mediated by the transcription factor HIF - 1 (hypoxia - inducible factor 1).

The BJRG look to continue to develop new approaches to skeletal regeneration, angiogenic development for tissue regeneration and new wound repair approaches.

HIF - 1 mediates vascular and progenitor cell responses to angiogenic signals, but these processes are impaired by aging and diabetes.

COX - 2 is an important pro-inflammatory protein expressed at high levels in tumoral angiogenic vessels.

Previous efforts to treat ischemia by creating new blood vessels have focused on delivering angiogenic growth factors like vascular endothelial growth factor (VEGF) to ischemic sites.

Furthermore, this study demonstrated that a biocompatible PA - RGDS nanomatrix gel substantially improved long - term survival of hPSC - ECs in an ischemic environment and improved neovascularization effects of hPSC - ECs via prolonged and unique angiogenic and vessel - forming properties.

However, the group receiving the PA - RGDS - encapsulated hPSC - ECs showed better perfusion recovery, more robust and longer cell survival (> 10 months), and higher and prolonged angiogenic and vascular incorporation capabilities than the bare hPSC - EC - injected group.

A review of the microcirculation of adipose tissue: anatomic, metabolic, and angiogenic perspectives.

It's also anti-invasive and seems to have angiogenic activity.

BCL9 promotes tumor progression by conferring enhanced proliferative, metastatic, and angiogenic properties to cancer cells.

Secretion of Angiogenic and Antiapoptotic Factors by Human Adipose Stromal Cells (March 16, 2004) in Circulation.

Recently, Ziaie and his team tested the device by implanting it into pancreatic tumors in mice and were able to show a decrease in interstitial tumor pressure following administration of an angiogenic inhibitor.

Therefore, those were chosen to test whether the molecules produced by the neural stem cells of patients alter the angiogenic capacity of the cells.

The results confirmed the results — substances produced by schizophrenia patients» nerve cells can hold back the angiogenic capacity of the epithelial cells.

«This is the first demonstration of the profile of angiogenic molecules expression using neural stem cells derived from patients with schizophrenia, which shows they have a less angiogenic profile when compared to controls,» says Palma.

When cultured under permissive temperatures (33 °C), individual cell lines displayed doubling times consistent with endothelial cells possessing an angiogenic phenotype.

Decreased phosphorylation of PDGFR - ß impairs the angiogenic potential of expanded endothelial progenitor cells via the inhibition of PI3K / Akt signaling.

The current paper builds a bridge between the nurse and building block approaches, because the researchers mix two complementary types of cells: an angiogenic one derived from bone marrow cells that expands existing blood vessels, and a vasculogenic one derived from embryonic stem cells that drives formation of new blood vessels. Note: embryonic stem cells were of mouse origin, not human.

Vice versa, pericyte recruitment by nascent vessels occurs during the later steps of the angiogenic cascade providing stabilization and maturation signals2.

In turn, tumour angiogenesis is characterized by a pathological patency of the angiogenic stimulus resulting in a chaotropic, pro-angiogenic and permanently immature vasculature.

However, clinical and new experimental data indicate early tumor dissemination immediately after an angiogenic switch has occurred and an intravasation of tumor cells in the tumor core region.

The research demonstrates that bioactive lipids have the ability to regulate inflammatory immune cells in the retina, key regulators of the angiogenic process in this disease.

In a new STEM CELLS Translational Medicine study, Zhang et al. now report that the overexpression of Platelet - Derived Growth Factor - BB (PDGF - BB), a well - known potent mitogenic, angiogenic, and chemoattractive agent, can significantly enhance dental tissue regeneration [5].

Medical research has shown adult stem cells to be angiogenic, meaning they stimulate the growth of new blood vessels.

Different in vitro assays were carried out in order to test the specific effects of kahweol treatment on several key steps of the angiogenic process in both endothelial and tumor cells.

Angiogenesis involves local proliferation of endothelial cells in response to an angiogenic stimulus.

The angiogenic response was quantified by microvessel counting according to published criteria [47].

«Flavonoids and Vitamin E Reduce the Release of the Angiogenic Peptide Vascular Endothelial Growth Factor from Human Tumor Cells».

The cancer - promoting growth hormone IGF - 1 is another angiogenic factor, helping tumors turn on the gravy train.

However, to date there are no canine - derived antibodies that bind and neutralize the angiogenic activity of canine VEGF.