Sentences with phrase «animal infection models»

In animal infection models using these pathogens, IL - 22 primarily plays a protective role by maintaining barrier integrity and thereby limiting bacterial dissemination.

The research team now concentrates on using CBS - based therapy in other animal infection models, e.g. urinary tract infection (UTI), hoping to offer a more extensive approach to combat with antibiotic resistant superbugs.

Way and his colleagues, including co-first authors Lucien Turner and Jeremy Kinder, PhD, stress that because study was in animal infection models, it's premature to say how the findings will apply clinically.

Not exact matches

Our study in an animal model found that influenza infection leads to an increase in the expression of muscle - degrading genes and a decrease in expression of muscle - building genes in skeletal muscles in the legs.

They then tested the contributions of samples from breast milk as well as individual molecules in both animal and cellular models of infection, measuring the length of time until resolution.

These findings allowed researchers to create a chimera virus: a mouse virus with a human viral gene that can be used to test molecules that inhibit human LANA protein in an animal model of disease, treating not only human herpes virus infection but also its associated cancers.

«Immune molecule protects against Zika virus infection in animal models: Molecule also protects against Zika - induced microcephaly in mouse model.»

Because the researchers found that CTLA4Ig was effective in suppressing hepatitis in this study, they suggest that CTLA4Ig should be among the therapeutic options investigated further as a potential therapy for patients with severe acute hepatitis B. To this end, this animal model is useful for virological and immunological analysis of HBV infection.

They go on to suggest that «lowering levels of TNF may be an effective strategy in improving host defense against S. pneumoniae in older adults,» and that, «although it may be counterintuitive to limit inflammatory responses during a bacterial infection, [some existing] clinical observations and our animal model indicate that anti-bacterial strategies need to be tailored to the age of the host.»

While the mouse study does not prove a direct connection between Zika infection and microcephaly, Rossi said, it does underscore the urgent need for effective animal models to further study the course of disease and its transmission.

The National Institutes of Health had agreed to fund the study, which involved creating an animal model of anthrax infection in baboons, and the university's animal use and care committee had given it the green light.

He had no animal model of the infection to use in his studies — rats and mice are not susceptible — so he famously used an experimental subject that did not require ethics approval or special funding: himself.

The abscesses contained Gram - negative bacteria, and when similar bacterial infections were deliberately induced in the CCM model animals, about half of them developed significant CCMs.

«Given the key similarities to human infections, a marmoset model of Zika may be useful for testing of new drug and vaccines,» said Texas Biomedical Research Institute virologist Jean Patterson, Ph.D. «Having an animal model of Zika infection to study may help us identify places where we might be able to block transmission.»

Pickles said that these findings in animal models were almost identical to what has been found in human infants who had died because of RSV infection.

The ongoing Zika virus outbreak in Latin America and the Caribbean has created an urgent need for identifying small animal models as a first step toward developing vaccines and treatments to fight the infection.

«The next stage would be to repeat the study in primates, a more suitable animal model where HIV infection induces disease, in order to further demonstrate elimination of HIV - 1 DNA in latently infected T cells and other sanctuary sites for HIV - 1, including brain cells,» Dr. Khalili said.

In addition to identifying how the virus causes acute liver injury, the UNC team, along with colleagues at North Carolina State University, established a new animal model of infection with the virus.

Although there are animal models of TB infection, results can be slow to emerge and also can be costly.

The researchers administered a potential vaccine consisting of two components to twelve rhesus monkeys that served as an animal model for the human HIV infection.

Using a mathematical model that combines a huge number of cattle and badgers that have TB, the researchers were able to quantify the relationship between the two animals and use a big data approach to show that the route of infection for cattle is from other cattle rather than from other species.

He hopes the animals will help him create more realistic mouse models of human chlamydia and salmonella infections.

The next step in this line of research is to examine the potency of the identified drugs in an animal model of CRE infection.

To test the capsule's real - world applications, the team used both mathematical modeling and animal models to investigate the effects of delivering a sustained therapeutic dose of a drug called ivermectin, which is used to treat parasitic infections such as river blindness.

Scientists at Technische Universität München (TUM) and the University of Tübingen have now shown in an animal model that these infections can severely disrupt the immune system, thus aggravating the skin condition.

«Our next step is to test Alphamers in animal models of infection with multidrug - resistant bacteria that pose a public health threat, such as MRSA,» said first author Sascha Kristian, PhD, visiting research scholar at UC San Diego and associate research director at Altermune Technologies, a company Mullis founded to develop Alphamers into unique therapeutics.

A new study in animal models suggests that blocking a protein that helps the virus thrive could restore immune function, allowing the body to fight infection.

Experimental animal models have been used to investigate many aspects of the clinical disease such as the sex bias in myocarditis where testosterones in males promote autoimmunity in the heart while estrogens in females suppress virus infection and autoimmunity.

IDMIT will contribute 1) To the development and validation of assays based on flow cytometry and mass cytometry for the evaluation of immune responses in humans and animal models; these tools will be particularly relevant for the identification of signatures of vaccine efficacy; 2) To the animal model platform, in particularly by providing access to NHP models and to new technologies for in vivo imaging infections and host responses; 3) To networking activities, in particular by organising a workshop on in vivo imaging.

Now, researchers at Harvard and Massachusetts General Hospital (MGH) and their colleagues have shown that amyloid - β can protect against yeast and bacterial infections in two animal models, as well as in cultured human cells.

Taking advantage of infected patients, proprietary animal models of infection and new technological advances in the field of static and dynamic imaging, Immunopathology Unit tackles unresolved issues that include the means by which innate and adaptive immune cells traffic and function within the normal, cirrhotic or cancerous livers.

«This is quite good and convincing work that confirms host defense activity of amyloid - β against fungal and bacterial infections in animal models, and begins to unravel the mechanisms of antimicrobial activity of the protein,» said Kevan Hartshorn who studies innate immunity at the Boston University School of Medicine and was not involved in the study.

Based on their expertise in immunology and pathology and the available infection models, vaccines against most relevant viral and bacterial animal infections can be tested.

Norovirus does not grow in cells and there is no animal model of infection.

One obstacle has so far been the lack of suitable animal models capable of recapitulating crucial aspects of the human infection.

Murine gammaherpesvirus 68 infection of IFNγ unresponsive mice: a small animal model for gammaherpesvirus - associated B - cell lymphoproliferative disease.

In this regard, animal model studies with FIPV in cats and RSV in mice have indicated that viral surface proteins may be the sensitizing protein of inactivated vaccines for immunopathology with infection [32], [45].

As indicated, strong animal model evidence indicates expression of the N protein by SARS - CoV vector vaccines can induce sensitization leading to a Th2 — type immunopathology with infection.

This experiment was conducted to verify the findings in the initial experiment of a hypersensitivity immunopathologic - like reaction after SARS - CoV challenge of vaccinated animals, to determine if a higher dosage of the S protein vaccine (SV) would suppress infection and still exhibit a similar reaction, and whether the original β propiolactone inactivated whole virus vaccine (BPV) that had shown an immunopathologic - like reaction after challenge of vaccinated ferrets and nonhuman primates exhibited a similar immunopathologic reaction in the mouse model [13], [14].

Whilst we do have some effective animal models for some sexually transmitted infections (e.g. Chlamydia) it is not currently certain if the mouse is an effective model organism for the Zika virus.

While mice, guinea pigs, dogs, rabbits and monkeys have been used as animal models to study B. burgdorferi infection, rhesus macaques have been shown to most closely recapitulate the multi-organ nature and progression of human LD [26, 27].

With all stages of clinical Lyme disease having previously been described in nonhuman primates, this animal model was selected in order to most closely mimic human infection and response to treatment.

The variation typified by this animal model should be exploited to uncover host differences and biomarkers indicative of responses to infection and treatment.

Reporting in Nature Medicine this week, Philip Johnson, a professor of pediatrics at the University of Pennsylvania, in Philadelphia, and his colleagues managed to protect monkeys from infection with the simian immunodeficiency virus (SIV), the animal model that is closest to HIV, by shuttling a gene into their muscles that produces antibody - like molecules that work against SIV.

Cao and his colleagues were able to develop an animal model of in utero infection to show that Zika was indeed a pathogen that could compromise the placenta's defenses.

I was excited about translating our promising in vitro results into therapies, but in 2001 there were still no good small animal models of HIV infection.

Armadillos never had leprosy until Europeans brought the bacillus to the New World; now the animals cause one - third of all leprosy infections contracted in the United States and serve as a leading model for leprosy research.

Moreover, knock in animal models for syngeneic studies and allowing us to isolate transgenic armed effector cells are developed in order to show proof of concept for the diverse applicability of our modular targeting systems including for tumor diseases, autoimmune diseases, GvHD, transplantation / rejection as well as viral infections.

This allowed for them to study infection in a model highly related to humans but without the need to infect a living animal.

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